Bis(chloromethyl)ether (BCME) Quickview (CASRN 542-88-1)

Status of Data for Bis(chloromethyl)ether (BCME)

File First On-Line: 09/26/1988; Last Significant Revision: 07/01/1991

Category (section)	Status	Last Revised
Oral RfD Assessment	No data
Inhalation RfC Assessment	Message	07/01/1991
Carcinogenicity Assessment	On-line	01/01/1991

Synonyms

542-88-1 Bis(chloromethyl)ether Chloro(chloromethoxy)methane Dichlordimethylaether 1,1'-Dichlorodimethyl ether

sym-Dichloro-dimethyl ether Dimethyl-1,1'-dichloroether Ether, bis(chloromethyl) Methane, oxybis(chloro- more...

Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure

• Weight-of-Evidence Characterization
  • A (Human carcinogen)
• Weight-of-Evidence Narrative:
  • Statistically significant increases in lung tumors (oat cell carcinomas) observed in six studies of exposed workers and bioassay data from rats and mice.
  • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

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Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)	Extrapolation Method
2.2 x102 per mg/kg-day	Linearized multistage procedure, extra risk

Drinking Water Unit Risks
6.2x10-3 per ug/L

Risk Level	Concentration
E-4 (1 in 10,000)	1.6x10-2 ug/L
E-5 (1 in 100,000)	1.6x10-3 ug/L
E-6 (1 in 1,000,000)	1.6x10-4 ug/L

• Dose-Response Data (Carcinogenicity, Oral Exposure)
  • Tumor Type: Respiratory tract tumors
  • Test Species: Rat/Sprague-Dawley, male
  • Route: Inhalation
  • Reference: Kuschner et al., 1975

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Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)	Extrapolation Method
6.2 x10-2 per ug/m3	Linearized multistage procedure, extra risk

Inhalation Concentrations at Specified Risk Levels

Risk Level	Concentration
E-4 (1 in 10,000)	1.6x10-3 ug/m3
E-5 (1 in 100,000)	1.6x10-4 ug/m3
E-6 (1 in 1,000,000)	1.6x10-5 ug/m3

• Dose-Response Data (Carcinogenicity, Inhalation Exposure)
  • Tumor Type: Respiratory tract tumors
  • Test Species: Rat/Sprague-Dawley, male
  • Route: Inhalation
  • Reference: Kuschner et al., 1975