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Lead and compounds (inorganic) Quickview (CASRN 7439-92-1)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Lead and compounds (inorganic)

File First On-Line: 03/01/1988; Last Significant Revision: 07/08/2004

Category (section)
Status
Last Revised
Oral RfD Assessment Discussion 07/08/2004
Inhalation RfC Assessment No data 07/08/2004
Carcinogenicity Assessment On-line 11/01/1993
Synonyms
  • 7439-92-1
  • Lead
  • Plumbum
  • Lead and compounds
  • Lead and compounds (inorganic)
Lead and compounds (inorganic) Source Documents
Revision History
Date Section Description
I.A., I.Bl, II. Previous reference value discussions replaced with links to EPA websites containing regulatory information and other websites with risk assessment information; cancer discussion retained, added links to agencies conducting reviews of lead carcinogenicity.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Information reviewed but value not estimated. See IRIS Summary.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Sufficient animal evidence. Ten rat bioassays and one mouse assay have shown statistically significant increases in renal tumors with dietary and subcutaneous exposure to several soluble lead salts. Animal assays provide reproducible results in several laboratories, in multiple rat strains with some evidence of multiple tumor sites. Short term studies show that lead affects gene expression. Human evidence is inadequate.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Information reviewed but value not estimated. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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