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Aniline Quickview (CASRN 62-53-3)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

For definitions of terms in the IRIS Web site, refer to the IRIS Glossary.

Status of Data for Aniline

File First On-Line: 09/07/1988; Last Significant Revision: 11/01/1990

Category (section)
Status
Last Revised
Oral RfD Assessment No data
Inhalation RfC Assessment On-line 12/01/1993
Carcinogenicity Assessment On-line 02/01/1994
Synonyms
  • 62-53-3
  • Aminobenzene
  • Aminophen
  • Aniline
  • Aniline-oil
  • Kyanol
  • Phenylamine
Aniline Source Documents
Revision History
Date Section Description
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementarry Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
 UF MF RfC
Lack of toxicity (other effect: Mild spleen toxicity. ) NOAEL (HEC): 3.4 mg/m3 3000 1 1x10-3 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Induction of tumors of the spleen and the body cavity in two strains of rat, and some supporting genetic toxicological evidence.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
5.7 x10-3 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
1.6x10-7 per ug/L
Risk Level
Concentration
E-4 (1 in 10,000) 6x102 ug/L
E-5 (1 in 100,000) 6x101 ug/L
E-6 (1 in 1,000,000) 6 ug/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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