1,4-Dichlorobenzene Quickview (CASRN 106-46-7)

Status of Data for 1,4-Dichlorobenzene

File First On-Line: 01/01/1994; Last Significant Revision: 01/01/1994

Category (section)	Status	Last Revised
Oral RfD Assessment	No data
Inhalation RfC Assessment	On-line	11/01/1996
Carcinogenicity Assessment	No data
Under Re-Assessment

Synonyms

106-46-7 1,4-Dichloorbenzeen [Dutch] 1,4-dichlorobenzene 1,4-Diclorobenzene [Italian] Benzene, 1,4-dichloro-

Benzene, p-dichloro- Caswell No. 632 Di-chloricide Dichlorobenzene, para more...

Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect	Point of Departure*	UF	MF	RfC
Increased liver weights in P1 males	NOAEL (HEC): 75 mg/m3	100	1	8x10-1 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

• Principal and Supporting Studies (Inhalation RfC)
  • Rat multigeneration reproductive study, Chlorobenzene Producers Assn., 1986
• Confidence in the Inhalation RfC
  • Study -- Medium
  • Database -- Medium
  • RfC -- Medium

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Carcinogenicity Assessment for Lifetime Exposure

• Weight-of-Evidence Characterization
  • Not Assessed under the IRIS Program.

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Quantitative Estimate of Carcinogenic Risk from Oral Exposure

• Not Assessed under the IRIS Program.

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Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

• Not Assessed under the IRIS Program.