Chlorothalonil (CASRN 1897-45-6)
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0143
Chlorothalonil;
CASRN 1897-45-6
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Chlorothalonil
File First On-Line 03/31/1987
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | on-line | 03/01/1988 |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — Chlorothalonil
CASRN — 1897-45-6
Last Revised — 03/01/1988
The oral Reference Dose (RfD) is based on the assumption that thresholds
exist for certain toxic effects such as cellular necrosis. It is expressed
in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty
spanning perhaps an order of magnitude) of a daily exposure to the human
population (including sensitive subgroups) that is likely to be without
an appreciable risk of deleterious effects during a lifetime. Please refer
to the Background Document for an elaboration of these concepts. RfDs
can also be derived for the noncarcinogenic health effects of substances
that are also carcinogens. Therefore, it is essential to refer to other
sources of information concerning the carcinogenicity of this substance.
If the U.S. EPA has evaluated this substance for potential human carcinogenicity,
a summary of that evaluation will be contained in Section II of this file.
__I.A.1. Oral RfD Summary
Critical Effect |
Experimental Doses* |
UF
|
MF
|
RfD
|
---|---|---|---|---|
Renal tubular 2-Year Dog Feeding Diamond Shamrock |
NOEL: 60 ppm converted LEL: 120 ppm (converted |
100
|
1
|
1.5E-2
mg/kg/day |
*Conversion Factors: 1 ppm diet = 0.025 mg/kg/day
__I.A.2. Principal and Supporting Studies (Oral RfD)
Diamond Shamrock Chemical Corporation. 1970a. MRID No. 00057702, 00114034.
Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Groups of eight male and eight female dogs were fed 0, 60, and 120 ppm
chlorothalonil for 2 years. Renal tubular epithelial vacuolation and
pigmentation were observed at 120 ppm.
__I.A.3. Uncertainty and Modifying Factors (Oral RfD)
UF — The UF of 100 accounts for uncertainties in the extrapolation from
laboratory animals to humans and for sensitive humans.
MF — None
__I.A.4. Additional Studies/Comments (Oral RfD)
Data Considered for Establishing the RfD:
1) 2-Year Feeding - dog: Principal study - see previous description; core
grade minimum
2) 13-Week Feeding - rat: NOEL=1.5 mg/kg/day; LEL=3.0 mg/kg/day; (irregular
intracytoplasmic inclusion bodies in the proximal convoluted tubule of males);
core grade guideline (Diamond Shamrock, 1983a)
3) 2-Year Feeding (oncogenic) - rat: Systemic NOEL=3.0 mg/kg/day (HDT); no
core grade (Diamond Shamrock, 1970b)
4) Teratology - rabbit: Maternal NOEL=5 mg/kg/day; Maternal LEL=50\mg/kg/day
(4 spontaneous abortions); core grade supplementary (Diamond Shamrock, 1975)
5) Teratology - rat: Maternal NOEL=100 mg/kg/day; Maternal LEL=400\mg/kg/day
(mortality, reduced body weight, increased resorptions and post implantation
bases); core grade guideline (Diamond Shamrock, 1983b)
6) 3-Generation Reproduction - rat: Reproductive LEL=75 mg/kg/day (LDT)
(depressed pup weight, and gastric and esophageal acanthosis in the
offspring); no core grade (Diamond Shamrock, 1967)
Data Gap(s): Rabbit Teratology Study; Rat Reproduction Study
__I.A.5. Confidence in the Oral RfD
Study — High
Database — Medium
RfD — Medium
The principal study appears to be of good quality and therefore is given a high confidence rating. The database is supportive, but some of the studies are of low quality. Thus, the database is given medium confidence. Medium confidence in the RfD follows.
__I.A.6. EPA Documentation and Review of the Oral RfD
Pesticide Registration Files
Agency Work Group Review — 04/08/1986
Verification Date — 04/08/1986
__I.A.7. EPA Contacts (Oral RfD)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — Chlorothalonil
CASRN — 1897-45-6
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — Chlorothalonil
CASRN — 1897-45-6
Not available at this time.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — Chlorothalonil
CASRN — 1897-45-6
Last Revised — 10/01/1990
_VI.A. Oral RfD References
Diamond Shamrock Agricultural Chemicals. 1967. MRID No. 00038913, 00091288,
00112736. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Diamond Shamrock Chemical Corporation. 1970a. MRID No. 00057702, 00114034.
Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Diamond Shamrock Chemical Corporation. 1970b. MRID No. 00035559. Available
from EPA. Write to FOI, EPA, Washington, DC 20460.
Diamond Shamrock Agricultural Chemicals. 1975. MRID No. 00127855. Available
from EPA. Write to FOI, EPA, Washington, DC 20460.
Diamond Shamrock Agricultural Chemicals. 1983a. MRID No. 00127852.
Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Diamond Shamrock Agricultural Chemicals. 1983b. MRID No. 00012963, 00130733.
Available from EPA. Write to FOI, EPA, Washington, DC 20460.
_VI.B. Inhalation RfC References
None
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — Chlorothalonil
CASRN — 1897-45-6
Date |
Section |
Description |
---|---|---|
03/01/1988 | I.A.1. | Dose conversion clarified |
03/01/1988 | I.A.5. | Confidence levels revised |
09/01/1989 | II. | Carcinogen assessment now under review |
11/01/1989 | VI. | Bibliography on-line |
10/01/1990 | III.A. | Health Advisory on-line |
10/01/1990 | VI.D. | Health Advisory references added |
01/01/1992 | IV. | Regulatory actions updated |
08/01/1995 | II. | EPA's RfD/RfC and CRAVE workgroups were discontinued in May, 1995. Chemical substance reviews that were not completed by September 1995 were taken out of IRIS review. The IRIS Pilot Program replaced the workgroup functions beginning in September, 1995. |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
01/12/2000 | I.A., II. | This chemical is being reassessed under the IRIS Program. |
02/09/2004 | I.A., II. | This chemical is no longer being reassessed under the IRIS Program. See Federal Register February 9, 2004 (Volume 69, Number 26). |
_VIII. Synonyms
Substance Name — Chlorothalonil
CASRN — 1897-45-6
Last Revised — 03/31/1987
- 1897-45-6
- 1,3-BENZENEDICARBONITRILE, 2,4,5,6-TETRACHLORO-
- BRAVO
- BRAVO 6F
- BRAVO-W-75
- CHLOROALONIL
- Chlorothalonil
- CHLORTHALONIL
- DAC 2787
- DACONIL
- DACONIL 2787
- DACOSOIL
- 1,3-DICYANOTETRACHLOROBENZENE
- EXOTHERM
- EXOTHERM TERMIL
- FORTURF
- ISOPHTHALONITRILE, TETRACHLORO-
- ISOPHTHALONITRILE, 2,4,5,6-TETRACHLORO-
- NCI-C00102
- NOPCOCIDE
- NOPCOCIDE N40D N96
- NOPCOCIDE N-96
- SWEEP
- TCIN
- m-TCPN
- TERMIL
- 2,4,5,6-TETRACHLORO-3-CYANOBENZONITRILE
- TETRACHLOROISOPHTHALO-NITRILE
- meta-TETRACHLOROPHTHALODINITRILE
- m-TETRACHLOROPHTHALONITRILE
- TPN