2(2,4,5-Trichlorophenoxy) propionic acid (2,4,5-TP) Quickview (CASRN 93-72-1)

Status of Data for 2(2,4,5-Trichlorophenoxy) propionic acid (2,4,5-TP)

File First On-Line: 08/22/1988; Last Significant Revision: 09/07/1988

Category (section)	Status	Last Revised
Oral RfD Assessment	On-line	09/07/1988
Inhalation RfC Assessment	No data
Carcinogenicity Assessment	On-line	08/22/1988

Synonyms

2 (2,4,5-Trichlorophenoxy) propionic acid 93-72-1 Acide 2-(2,4,5-trichloro-phenoxy) propionique Acido 2-(2,4,5-tricloro-fenossi)-propionico alpha-(2,4,5-Trichlorophenoxy)propionic acid

Propanoic acid, 2-(2,4,5-trichlorophenoxy)- Propionic acid, 2-(2,4,5-trichlorophenoxy)- Silvex 2,4,5-Tp more...

Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect	Point of Departure*	UF	MF	RfD
Histopathological changes in liver	NOEL : 0.75 mg/kg-day	100	1	8 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

• Principal and Supporting Studies (Oral RfD)
  • Dog chronic oral bioassay, Mullison, 1966; Gehring and Betso, 1978
• Confidence in the Oral RfD
  • Study -- Medium
  • Database -- Medium
  • RfD -- Medium

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure

• Weight-of-Evidence Characterization
  • D (Not classifiable as to human carcinogenicity)
• Weight-of-Evidence Narrative:
  • Human data are not available and the available animal cancer bioassay studies are considered to be inadequate.
  • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

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Quantitative Estimate of Carcinogenic Risk from Oral Exposure

• Not Assessed under the IRIS Program.

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Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

• Not Assessed under the IRIS Program.