2,4,6-Trichlorophenol Quickview (CASRN 88-06-2)

Status of Data for 2,4,6-Trichlorophenol

File First On-Line: 01/31/1987; Last Significant Revision: 07/01/1991

Category (section)	Status	Last Revised
Oral RfD Assessment	No data
Inhalation RfC Assessment	Message	07/01/1991
Carcinogenicity Assessment	On-line	02/01/1994

Synonyms

88-06-2 Dowicide 2s NCI-C02904 Phenol, 2,4,6-trichloro- RCRA Waste Number U231

Trichlorophenol, 2,4,6- Omal Phenachlor 2,4,6-Trichlorophenol Trichlorophenol

Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure

• Weight-of-Evidence Characterization
  • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
• Weight-of-Evidence Narrative:
  • Based on no human data and sufficient evidence in animals; namely, increased incidence of lymphomas or leukemias in male rats and hepatocellular adenomas or carcinomas in male and female mice.
  • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

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Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)	Extrapolation Method
1.1 x10-2 per mg/kg-day	Linearized multistage procedure, extra risk

Drinking Water Unit Risks
3.1x10-7 per ug/L

Risk Level	Concentration
E-4 (1 in 10,000)	3x102 ug/L
E-5 (1 in 100,000)	3x101 ug/L
E-6 (1 in 1,000,000)	3 ug/L

• Dose-Response Data (Carcinogenicity, Oral Exposure)
  • Tumor Type: Leukemia
  • Test Species: Rat/F344, male
  • Route: Oral, Diet
  • Reference: NCI, 1979

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Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)	Extrapolation Method
3.1 x10-6 per ug/m3	Linearized multistage procedure, extra risk

Inhalation Concentrations at Specified Risk Levels

Risk Level	Concentration
E-4 (1 in 10,000)	3x101 ug/m3
E-5 (1 in 100,000)	3 ug/m3
E-6 (1 in 1,000,000)	3x10-1 ug/m3

• Dose-Response Data (Carcinogenicity, Inhalation Exposure)
  • Tumor Type: Leukemia
  • Test Species: Rat/F344, male
  • Route: Oral, Diet
  • Reference: NCI, 1979