Publications

Cardiac Cytochrome c Oxidase Activity and Contents of Submits 1 and 4 are Altered in Offspring by Low Prenatal Intake by Rat Dams - (Peer Reviewed Journal)

Johnson, W.T., Anderson, C.M. 2008. Cardiac Cytochrome c Oxidase Activity and Contents of Submits 1 and 4 are Altered in Offspring by Low Prenatal Intake by Rat Dams. Journal of Nutrition. 138:1269-1273

Copper Deficiency Inhibits CA2+-Induced Swelling in Rat Cardiac Mitochondria - (Peer Reviewed Journal)

Johnson, W.T., Johnson, L.K. 2008. Copper Deficiency Inhibits CA2+-Induced Swelling in rat Cardiac Mitochondria. Journal of Nutritional Biochemistry.doi.10.1016/j.jnutbio.2008.02.009

A combined marginal deficiency of copper and zinc does not exacerbate oxidant stress asssociated with copper or zinc deficiency - (Abstract)

Nielsen, F.H. 2008. A combined marginal deficiency of copper and zinc does not exacerbate oxidant stress asssociated with copper or zinc deficiency. [abstract] Journal of Federation of American Societies for Experimental Biology. 22:1103.1.

Relative bone mass decreased in mice fed high dietary fat despite an increase in body mass and bone formation markers - (Abstract)

Cao, J.J. 2008. Relative bone mass decreased in mice fed high dietary fat despite an increase in body mass and bone formation markers [Abstract]. Journal of Federation of American Societies for Experimental Biology. 22:314.1.

Prenatal copper deficiency in rat dams causes persistent reduction in nuclear-encoded cytochrome c oxidase subunits in cardiac mitochrondria of the first generation - (Abstract)

Johnson, W.T., Anderson, C. 2008. Prenatal copper deficiency in rat dams causes persistent reduction in nuclear-encoded cytochrome c oxidase subunits in cardiac mitochrondria of the first generation [Abstract]. Journal of Federation of American Societies for Experimental Biology. 22:443.2.

Dietary selenium (Se) and copper (Cu) interact to affect homocysteine metabolism in rats - (Abstract)

Uthus, E.O., Ross, S.A. 2008. Dietary selenium (Se) and copper (Cu) interact to affect homocysteine metabolism in rats [Abstract]. Journal of Federation of American Societies for Experimental Biology. 22:696.3.

Marginal copper deficiency impairs endothelium-dependent relaxation responses across two generations - (Abstract)

Anderson, C.M., Johnson, W.T. 2008. Marginal copper deficiency impairs endothelium-dependent relaxation responses across two generations [Abstract]. Journal of Federation of American Societies for Experimental Biology. 22:695.1.

Marginal copper deficiency in pregnancy: Vascular responses in dams and progeny - (Abstract)

Anderson, C.M., Johnson, W.T. 2007. Marginal copper deficiency in pregnancy: Vascular responses in dams and progeny. [abstract] Presented at Aspen Perinatal Biology Symposium, August 25-28, 2007, Aspen, CO. Abstracts were not published.

Copper deficiency decreases plasma homocysteine in rats - (Peer Reviewed Journal)

Uthus, E.O., Reeves, P.G., Saari, J.T. 2007. Copper deficiency decreases plasma homocysteine in rats. Journal of Nutrition. 137:1370-1374.

Dietary copper supplementation reverses hypertrophic cardiomyopathy induced by chronic pressure overload in mice - (Peer Reviewed Journal)

Jiang, Y., Reynolds, C., Xiao, C., Feng, W., Zhou, Z., Rodriguez, W., Tyagi, S., Eaton, J.W., Saari, J.T., Kang, Y.J. 2007. Dietary copper supplementation reverses hypertrophic cardiomyopathy induced by chronic pressure overload in mice. Journal of Experimental Medicine. 204(3):657-666.

Dietary interaction of high fat and marginal copper deficiency on cardiac contractile function - (Peer Reviewed Journal)

Relling, D.P., Esberg, L.B., Johnson, W.T., Murphy, E.J., Carlson, E.C., Lukaski, H.C., Saari, J.T., Ren, J. 2007. Dietary interaction of high fat and marginal copper deficiency on cardiac contractile function. Obesity. 15(5):1242-1257.

Copper deficiency attenuates endothelial nitric oxide release - (Abstract)

Schuschke, D.A., Johnson, W.T., Falcone, J.C. 2007. Copper deficiency attenuates endothelial nitric oxide release [abstract]. Journal of Federation of American Societies for Experimental Biology.21(5):A721.

Prenatal Cu intake by rat dams is the principle determinant of cardiac cytochrome c oxidase activity in their offspring - (Abstract)

Johnson, W.T., Anderson, C.M. 2007. Prenatal Cu intake by rat dams is the principle determinant of cardiac cytochrome c oxidase activity in their offspring [abstract]. Journal of Federation of American Societies for Experimental Biology. 21(5):A722.

Copper deficiency decreases the protein expression of Complex IV but not Complex I, II, III and V in mitochondrial respiratory chain in rat heart - (Abstract)

Zeng, H., Saari, J.T., Johnson, W.T. 2007. Copper deficiency decreases the protein expression of Complex IV but not Complex I, II, III and V in mitochondrial respiratory chain in rat heart [abstract]. Journal of Federation of American Societies for Experimental Biology. 21(5):A722.

Copper deficiency decreases the protein expression of Complex IV but not Complex I, II, III, or V in mitochondrial respiratory chain in rat heart - (Peer Reviewed Journal)

Zeng, H., Saari, J.T., Johnson, W.T. 2007. Copper deficiency decreases complex IV but not complex I, II, III, or V in the mitochondrial respiratory chain in rat heart. Journal of Nutrition. 137:14-18.

Pinto beans are a source of highly bioavailable copper - (Peer Reviewed Journal)

Saari, J.T., Reeves, P.G., Johnson, W.T., Johnson, L.K. 2006. Pinto beans are a source of highly bioavailable copper. Journal of Nutrition. 136:2999-3004.

CARDIAC NITRIC OXIDE SYNTHASES ARE ELEVATED IN DIETARY COPPER DEFICIENCY - (Peer Reviewed Journal)

Saari, J.T., Wold, L.E., Duan, J., Ren, J., Carlson, H.L., Bode, A.M., Lentsch, A.B., Zeng, H., Schuschke, D.A. 2006. Cardiac nitric oxide synthases are elevated in dietary copper deficiency. Journal of Nutritional Biochemistry. doi:10.1016/j.jnutbio.2006.07.006.

RHOA SIGNAL TRANSDUCTION: EFFECTS OF MATERNAL COPPER DEFICIENCY ON PROGENY - (Abstract)

Anderson, C.A., Brown-Borg, H.M., Johnson, W.T. 2006. Rhoa signal transduction: Effects of maternal copper deficiency on progeny [abstract]. Presented by Cindy A. Anderson at the 4th International Congress on Developmental Origins of Health and Disease (DOHaD). University of Utrecht, The Netherlands. September 12-16, 2006.

DIETARY MAGNESIUM DEFICIENCY INDUCES HEART RHYTHM CHANGES, IMPAIRS GLUCOSE TOLERANCE, AND DECREASES SERUM CHOLESTEROL IN POST MENOPAUSAL WOMEN - (Peer Reviewed Journal)

Nielsen, F.H., Milne, D.B., Klevay, L.M., Gallagher, S., Johnson, L.K. 2007. Dietary magnesium deficiency induces heart rhythm changes, impairs glucose tolerance, and decreases serum cholesterol in post menopausal women. Journal of the American College of Nutrition. 26(2):121-132.

Hearts in adult offspring of copper-deficient dams exhibit decreased cytochrome c oxidase activity, increased mitochondrial hydrogen peroxide generation and enhanced formation of intracellular residual bodies - (Peer Reviewed Journal)

Johnson, W.T., Newman Jr, S.M. 2007. Hearts in adult offspring of copper-deficient dams exhibit decreased cytochrome c oxidase activity, increased mitochondrial hydrogen peroxide generation and enhanced formation of intracellular residual bodies. Journal of Nutritional Biochemistry. 18:97-104.

INDICATIONS OF MAGNESIUM AND CALCIUM DEFICIENCY IN POPULATIONS - (Abstract)

Combs, G.F. 2006. Indications of magnesium and calcium deficiency in populations [abstract]. International Symposium on Health Aspects of Calcium and Magnesium in Drinking Water, Program and Abstracts, p. 41.

DIETARY MAGNESIUM DEPRIVATION CONFIRMED BY BALANCE INDUCES BIOCHEMICAL AND FUNCTIONAL CHANGES INCLUDING CALCIUM BALANCE IN POSTMENOPAUSAL WOMEN - (Abstract)

Nielsen, F.H. 2006. Dietary magnesium deprivation confirmed by balance induces biochemical and functional changes including calcium balance in postmenopausal women [abstract]. International Symposium on Health Aspects of Calcium and Magnesium in Drinking Water, Program and Abstracts. p. 43-44.

CARDIAC METALLOTHIONEIN INDUCTION PLAYS THE MAJOR ROLE IN THE PREVENTION OF DIABETIC CARDIOMYOPATHY BY ZINC SUPPLEMENTATION - (Peer Reviewed Journal)

Wang, J., Song, Y., Elsherif, L., Song, Z., Zhou, G., Prabhu, S.D., Saari, J.T., Cai, L. 2006. Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation. Circulation. 113:544-554.

HIGH-FAT DIET-INDUCED JUVENILE OBESITY LEADS TO CARDIOMYOCYTE DYSFUNCTION AND UPREGULATION OF FOXO3A TRANSCRIPTION FACTOR INDEPENDENT OF LIPOTOXICITY AND APOPTOSIS - (Peer Reviewed Journal)

Relling, D.P., Esberg, L.B., Fang, C.X., Johnson, W.T., Murphy, E.J., Carlson, E.C., Saari, J.T., Ren, J. 2006. High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis. Journal of Hypertension. 24:549-561.

NEW FINDINGS ON PROTEIN EXPRESSION ON COPPER DEFICIENT RAT HEART WITH PROTEOMIC APPROACH - (Abstract)

Zeng, H., Saari, J.T. 2006. New findings on protein expression on copper deficient rat heart with proteomic approach [abstract]. FASEB J. 20(4):A553.

CU-REPLETION PROMOTES ANGIOGENESIS IN THE CU-DEFICIENT RAT HEART - (Abstract)

Schuschke, D.A., Williams, C., Kang, Y.J., Saari, J.T. 2006. Cu-repletion promotes angiogenesis in the Cu-deficient rat heart [abstract]. Journal of Federation of American Societies for Experimental Biology. 20(4):A553.

PINTO BEANS ARE A GOOD SOURCE OF DIETARY COPPER - (Abstract)

Saari, J.T., Reeves, P.G. 2006. Pinto beans are a good source of dietary copper [abstract]. Journal of Federation of American Societies for Experimental Biology. 20(4):A554.

CARDIAC MITOCHONDRIAL FUNCTION IS ALTERED IN THE ADULT OFFSPRING OF COPPER-DEFICIENT DAMS - (Abstract)

Johnson, W.T., Newman, Jr., S.M. 2006. Cardiac mitochondrial function is altered in the adult offspring of copper-deficient dams [abstract]. Journal of Federation of American Societies for Experimental Biology. 20(5):A1065.

COPPER DEFICIENCY INCREASES FIBULIN-5 (DANCE/EVEC) BUT DECREASES CYTOCHROME C OXIDASE VIB EXPRESSION IN RAT HEART - (Peer Reviewed Journal)

Zeng, H., Saari, J.T., Dahlen, G.M. 2005. Copper deficiency increases fibulin-5 (dance/evec) but decreases cytochrome c oxidase vib expression in rat heart. Inorganic Biochemistry. 100:186-91.

CARDIAC CYTOCHROME-C OXIDASE DEFICIENCY OCCURS DURING LATE POSTNATAL DEVELOPMENT IN PROGENY OF COPPER-DEFICIENT RATS - (Peer Reviewed Journal)

Johnson, W.T., Brown-Borg, H.M. 2006. Cardiac cytochrome-c oxidase deficiency occurs during late postnatal development in progeny of copper-deficient rats. Experimental Biology and Medicine. 231:172-180.

MARGINAL DIETARY COPPER RESTRICTION INDUCES CARDIOMYOPATHY IN RATS - (Peer Reviewed Journal)

Li, Y., Wang, L., Schuschke, D.A., Zhou, Z., Saari, J.T. 2005. Marginal dietary copper restriction induces cardiomyopathy in rats. Journal of Nutrition. 135:2130-2136.

IMPAIRED DEFORMABILITY OF COPPER-DEFICIENT NEUTROPHILS - (Peer Reviewed Journal)

Gordon, S.A., Lominadze, D., Saari, J.T., Lentsch, A.B., Schuschke, D.A. 2005. Impaired deformability of copper-deficient neutrophils. Experimental Biology and Medicine. 230:543-548.

ALCOHOL-INDUCED MYOCARDIAL FIBROSIS IN METALLOTHIONEIN-NULL MICE: PREVENTION BY ZINC SUPPLEMENTATION - (Peer Reviewed Journal)

Wang, L., Zhou, Z., Saari, J.T., Kang, Y.J. 2005. Alcohol-induced myocardial fibrosis in metallothionein-null mice: Prevention by zinc supplementation. American Journal of Pathology. 167(2):337-344.

ARSENIC - (Book/Chapter)

Nielsen, F.H. 2006. Arsenic. In: Klasing, K.C., editor. Mineral Tolerance of Animals. 2nd Revised Edition. Washington DC; National Academies Press. p. 31-41.

CARDIAC METALLOTHIONEIN SYNTHESIS IN STREPTOZOTOCIN -INDUCED DIABETIC MICE, AND ITS PROTECTION AGAINST DIABETES-INDUCED CARDIAC INJURY - (Peer Reviewed Journal)

Song, Y., Wang, J., Li, Y., Du, Y., Arteel, G.E., Saari, J.T., Kang, Y.J., Cai, L. 2005. Cardiac metallothionein synthesis in streptozotocin-induced diabetic mice, and its protection against diabetes-induced cardiac injury. American Journal of Pathology. 167(1):17-26.

INCREASED CONTRACTILITY OF CARDIOMYOCYTES FROM COPPER-DEFICIENT RATS IS ASSOCIATED WITH UPREGULATION OF CARDIAC INSULIN-LIKE GROWTH FACTOR-I RECEPTOR - (Peer Reviewed Journal)

Dong, F., Esberg, L.B., Roughead, Z.K., Ren, J., Saari, J.T. 2005. Increased contractility of cardiomyocytes from copper-deficient rats is associated with upregulation of cardiac insulin-like growth factor-I receptor. American Journal of Physiology Heart and Circulatory Physiology. 289:78-84.

INCREASED CONTRACTILITY IS ASSOCIATED WITH INCREASED CARDIAC IGF-I RECEPTOR PROTEIN IN COPPER-DEFICIENT CARDIOMYOCYTES - (Abstract)

Saari, J.T., Dong, F., Esberg, L.B., Roughead, Z.K., Ren, J. 2005. Increased contractility is associated with increased cardiac IGF-I receptor protein in copper-deficient cardiomyocytes [abstract]. The Federation of American Societies for Experimental Biology Journal. 19(5):A1486.

SERUM SUPEROXIDE DISMUTASE (SOD) ACTIVITY IS AN INDEX OF COPPER STATUS - (Abstract)

Johnson, W.T., Lukaski, H.C. 2005. Serum superoxide dismutase (SOD) activity is an index of copper status [abstract]. The Federation of American Societies for Experimental Biology Journal. 19(5):A1485.

IMPAIRED DEFORMABILITY IN COPPER-DEFICIENT NEUTROPHILS - (Abstract)

Schuschke, D.A., Gordon, S.A., Saari, J.T., Lentsch, A.B. 2005. Impaired deformability of copper-deficient neutrophils [abstract]. The Federation of American Societies for Experimental Biology Journal. 19(5):A1485.