2006 Annual Report 4d.Progress report. This report serves to document research conducted under a Reimbursable Agreement with the National Cancer Institute (NCI). Additional details of the research can be found in the report for the parent project 1235-51000-046-00D, Bioavailability and Metabolism of Phytochemicals and Other Micronutrients. Brassica vegetables, such as broccoli, Brussels sprouts, cabbage, and mustard, provide dieatary allyl isothiocyanate, a compound that is thought to have great cancer preventative properties. In collaboration with the NCI, the Beltsville Human Nutrition Research Center’s Diet and Human Performance Lab has begun a study of the absorption of allyl isothiocyanate and its potential to decrease cancer risk factors. A thorough literature search has been completed, and the clinical study has been designed. The Institutional Review Board protocol has been written and approved. The results of the study will benefit scientists studying cancer prevention and consumers and health professionals in planning healthful diets.