Final Report: Neurobehavioral Effects of Prevalent Toxicants in Children
EPA Grant Number: R829389C001Subproject: this is subproject number 001 , established and managed by the Center Director under grant R829389
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: CECEHDPR - University of Cincinnati Center for the Study of Prevalent Neurotoxicants in Children
Center Director: Lanphear, Bruce
Title: Neurobehavioral Effects of Prevalent Toxicants in Children
Investigators: Lanphear, Bruce , Dietrich, Kim
Institution: Children Hospital of Cincinnati , University of Cincinnati
EPA Project Officer: Fields, Nigel
Project Period: November 1, 2001 through October 31, 2006
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001)
Research Category: Children's Health , Health Effects
Description:
Objective:The HOME Study is a longitudinal cohort study which examines the effect of low-level exposures (pre- and postnatal) of prevalent toxicants on neurobehavioral outcomes and development disorders, and tests meconium levels as a measure of in utero exposures to numerous toxicants. We are also conducting a nested, randomized controlled trial to test the efficacy of lead hazard controls on blood lead concentrations and developmental conditions and the efficacy of injury hazard controls on injury incidence and severity. Finally, this study provides data that are essential for exposure assessment and risk characterization for prevalent residential pesticides in childhood.
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To examine the effects of low-level exposures to prevalent neurotoxicants in a cohort of 400 children followed from less than 16 weeks gestation to 5 years of age.
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To conduct a nested, randomized controlled trial to test the efficacy of lead hazard controls on children’s blood lead levels and their risk for learning and behavioral problems.
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To determine the efficacy of housing modifications on children’s risk for injuries.
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To provide data that are essential for exposure assessment and risk characterization for prevalent residential pesticides in childhood.
Thus far, we have lead, mercury, PCBs, cotinine and pesticides results from maternal blood taken three times during pregnancy and cord blood. We also have preliminary results for organophosphrous and pyrethroid pesticide metabolites from maternal urine during pregnancy for the
Data analyses continues. Bruce Lanphear, MD, MPH received funding for an R01, project period ending April 2012, to extend the duration of follow-up of the birth cohort to the age of 5 years. Journal Articles:
No journal articles submitted with this report: View all 19 publications for this subproject
Supplemental Keywords:toxicology, ADHD, behavioral assessment, behavioral deficit, genetic susceptibility, pesticides, biomarkers, environmental agents, exposure, exposure assessment, hearing loss, lead, meconium, neurotoxicity, pesticide exposure, risk assessment, toxicants, lead-based paint, lead hazard control,
, Toxics, ENVIRONMENTAL MANAGEMENT, Scientific Discipline, Health, RFA, Toxicology, Risk Assessment, Biology, Risk Assessments, Health Risk Assessment, Chemistry, Children's Health, pesticides, exposure assessment, toxicity, lead, pesticide exposure, biological markers, children, biomarker, behavioral deficits, behavioral assessmentRelevant Websites:
www.cincinnatichildrens.org/homestudy/
Progress and Final Reports:
2003 Progress Report
2004 Progress Report
2005 Progress Report
Original Abstract
Main Center Abstract and Reports:
R829389 CECEHDPR - University of Cincinnati Center for the Study of Prevalent Neurotoxicants in Children
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R829389C001 Neurobehavioral Effects of Prevalent Toxicants in Children
R829389C002 Validation of Meconium Markers of Fetal Neurotoxicant Exposures
R829389C003 Community-Based Research Project Identifying Residential Hazards Using Home Test Kits
R829389C004 Early Exposure to Lead and Adult Antisocial Outcome
R829389C005 Magnetic Resonance Assessment of Brain Function Altered by Lead Exposure