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CECEHDPR - University of Michigan
EPA Grant Number: R826710Center: Michigan Center for the Environment and Children’s Health
Center Director: Israel, Barbara A.
Title: CECEHDPR - University of Michigan
Investigators: Israel, Barbara A.
Institution: University of Michigan - Ann Arbor
EPA Project Officer: Fields, Nigel
Project Period: September 1, 1998 through August 31, 2003 (Extended to August 31, 2005)
Project Amount: $2,830,746
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998)
Research Category: Children's Health , Health Effects
Description:
Objective:Childhood asthma is one of the most common chronic pediatric diseases and poses a serious public health problem. The prevalence of the disease in the city of Detroit is particularly high, reflecting the trends found elsewhere among urban populations and communities of color. The Michigan Center for the Environment and Children's Health (MCECH) will engage in coordinated interdisciplinary research aimed at: 1) identifying children with asthma and assess their household, school, and neighborhood environment, 2) increasing knowledge and behavior to reduce environmental hazards in households and neighborhoods, thereby improving asthma-related health status, 3) examining the effects of daily and seasonal fluctuations in indoor and outdoor ambient air quality on pulmonary function and severity of asthma symptoms, 4) determining the effects of allergen-induced local, excessive production of chemokines on redox status and innervation of the bronchial tree, and 5) developing specific mechanisms for communication and translation of laboratory and community-based research across disciplines and to community partners. The Center will include three research cores, Asthma Intervention (Core 1), Asthma Exposure (Core 2) and Asthma Chemokines (Core 3), supported by two Facility Cores (Biostatistics and Exposure Assessment) and an Administrative Core, and two new Center Scientists.
The Center is a partnership involving the University of Michigan Schools of Public Health and Medicine, the Detroit Health Department, Henry Ford Health System, community-based organizations based on the southwest and east sides of Detroit, including Butzel Family Center, Community Health and Social Services Center (CHASS), Detroiters Working for Environmental Justice, Friends of Parkside, Kettering/Butzel Health Initiative, Latino Family Services, United Community Housing Coalition, and Warren/Conner Development Coalition, and the Centers for Disease Control and Prevention (CDC.) The Center builds on a partnership established in 1995 by the Detroit Community-Academic Urban Research Center (URC), one of three "Urban Centers for Applied Research" funded by the CDC. The Detroit URC seeks to develop and implement prevention research that improves the health of children and families in selected communities in southwest and east side Detroit. The Detroit URC Board, comprised of representatives of many of the same partners currently participating in the new Center, adopted a set of "Community-Based Research Principles" to guide the development of research projects carried out in conjunction with the URC. These research principles include an emphasis on: the local relevance of public health problems; the involvement of community, practitioner, and academic partners in all major phases of the research process; the conduct of research that is beneficial to the community involved; and the dissemination of research findings to community members in ways that are understandable and useful. In 1996 the URC Board, after a review of relevant data and discussion of interests and needs of partner organizations, identified three overall priority areas for developing new community-based prevention research projects. One of these priorities was the area of environmental health and in particular housing and air quality as it relates to asthma in children. The URC Board enthusiastically and unanimously decided to be involved in submitting a proposal for the new Center that would focus on identifying and reducing environmental exposures considered to be associated with asthma health status in children.
Journal Articles: 26 Displayed | Download in RIS Format
| Other center views: | All 46 publications | 26 publications in selected types | All 26 journal articles |
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Clark NM, Brown RW, Parker EA, Robins TG, Remick DG, Philbert MA, et al. Childhood asthma. Environmental Health Perspectives. 1999;107:421-429. |
R826710 (Final) R826710C001 (1999) R826710C002 (1999) R826710C003 (1999) |
not available |
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Dvonch T, Marsik FJ, Keeler GJ, Robins TG, Yip F, Morishita M. Field comparison of PM2.5 TEOM and PM2.5 manual filter-based measurement methods in urban atmospheres. Journal of Aerosol Science. 2000;31:S190-S191 |
R826710 (Final) |
not available |
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Edgren KK, Parker EA, Israel BA, Lewis TC, Salinas M, Robins TG, Hill YR. Conducting a health education intervention and an epidemiological research project involving community members and community partner organizations: The Community Action Against Asthma Project.Health Promotion Practice2005;6(3):263-269. |
R826710 (Final) |
not available |
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Eggleston PA, Diette G, Lipsett M, Lewis T, Tager I, McConnell R, Chrischilles E, Lanphear B, Miller R, Krishnan J. Lessons learned from the study of childhood asthma from the Centers for Children’s Environmental Health and Disease Prevention research. Environmental Health Perspectives 2005;113(10):1430-1436. |
R826710 (Final) R827027 (2002) R829389 (2003) R829389 (2004) R829389 (2005) R831710 (2004) R831710 (2005) R831861 (2005) R832139 (2004) R832139 (2005) R832139C002 (2005) R832139C003 (2005) R832141 (2006) |
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Farquhar SA, Parker EA, Israel BA. In their words: A qualitative analysis of the effects of the physical environment on Detroit residents.Local Environment2005;10(3): 259-274. |
R826710 (Final) |
not available |
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Farquhar SA, Parker EA, Schulz AJ, Israel BA. In their words: How Detroit residents perceive the effects of their physical environment. Local Environment. 2005;10(3):259-274. |
R826710 (Final) |
not available |
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Farquhar SA, Parker EA, Israel BA, Schulz AS. The effects of the physical environment on health and well-being in residents of eastside and southwest Detroit, Michigan. Journal of Environmental Psychology. |
R826710 (2002) |
not available |
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Gilliland F, Avol E, Kinney P, Jerrett M, Dvonch T, Lurmann F, Buckley T, Breysse P, Keeler G, de Villiers T, McConnell R. Air pollution exposure assessment for epidemiologic studies of pregnant women and children: lessons learned from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1447-1454. |
R826710 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R827027 (2002) R831845 (2005) R831861 (2004) R831861 (2005) R832141 (2006) |
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Israel BA, Parker EA, Rowe Z, Salvatore A, Minkler M, Lopez J, Butz A, Mosley A, Coates L, Lambert G, Potito PA, Brenner B, Rivera M, Romero H, Thompson B, Coronado G, Halstead S. Community-based participatory research: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1463-1471. |
R826710 (Final) R829391 (2004) R829391 (2005) R829391 (2006) R829391C005 (2006) R831709 (2005) R831709C003 (2005) R831709C003 (2006) R831710 (2004) R831710 (2005) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Israel BA, Schulz AJ, Parker EA, Becker AB, Allen AJ, Guzman JR. Critical issues in developing and following community-based participatory research principles. In: M Minkler and N Wallerstein, editors. Community-Based Participatory Research for Health. San Francisco, CA: Jossey-Bass; 2003:56-73. |
R826710 (Final) |
not available |
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Keeler GJ, Dvonch JT, Yip F, Parker EA, Israel BA, Marsik FJ, et al. Assessment of personal and community-level exposures to particulate matter among children with asthma in Detroit, Michigan, as part of Community Action Against Asthma (CAAA). Environmental Health Perspectives. 2002;110:173-181. |
R826710 (2002) R826710 (Final) |
not available |
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Kim J, Merry AC, Nemzek JA, Bolgos GL, Siddiqui J, Remick DG. Eotaxin Represents the Principal Eosinophil Chemoattractant in a Novel Murine Asthma Model Induced by House Dust Containing Cockroach Allergens. Journal of Immunology 2001;167:2808-2815. |
R826710 (2002) R826710 (Final) |
not available |
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Kim J, McKinley L, Natarajan S, Bolgos GL, Siddiqui J, Copeland S, Remick DG. Anti-tumor necrosis factor-alpha antibody treatment reduces pulmonary inflammation and methacholine hyper-responsiveness in a murine asthma model induced by house dust.Clinical and Experimental Allergy2006;36(1):122-132. |
R826710 (Final) |
not available |
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Kim J, McKinley L, Siddiqui J, Bolgos G, Remick DG. Prevention and reversal of pulmonary inflammation and airway hyperresponsiveness by dexamethasone treatment in a murine model of asthma induced by house dust. American Journal of Physiology - Lung Cellular & Molecular Physiology. 2004;287(3):L503-L509. |
R826710 (Final) |
not available |
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Lewis TC, Robins TG, Dvonch JT, Keeler GJ, Yip FY, Mentz GB, et al. Air pollution associated changes in lung function among asthmatic children in Detroit. Environmental Health Perspectives2005;113(8):1068-1075. |
R826710 (Final) |
not available |
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Lopéz ED, Parker EA, Edgren KK, Brakefield-Caldwell W. Lessons learned while using a CBPR approach to plan and conduct forums to disseminate research findings back to partnering communities. Metropolitan Universities Journal 2005;16(1):57-76. |
R826710 (Final) |
not available |
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McKinley L, Kim J, Bolgos GL, Siddiqui J, Remick DG. CXC chemokines modulate IgE secretion and pulmonary inflammation in a model of allergic asthma. Cytokine2005;32(3-4):178-85. |
R826710 (Final) |
not available |
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McKinley L, Kim J, Bolgos GL, Siddiqui J, Remick DG.Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice.Respiratory Research2006;7:129. |
R826710 (Final) |
not available |
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McKinley L, Kim J, Bolgos GL, Siddiqui J, Remick DG. Reproducibility of a novel model of murine asthma-like pulmonary inflammation. Clinical & Experimental Immunology. 2004;136:224-231. |
R826710 (Final) |
not available |
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Parker EA, Israel BA, Robins TG, Mentz G, Lin X, Brakefield-Caldwell W, Ramirez E, Edgren KK, Salinas M, Lewis TC. Evaluation of Community Action Against Asthma: A community health worker intervention to improve children's asthma-related health by reducing household environmental triggers for asthma. Health Education and Behavior2008;35(3):376-395. |
R826710 (Final) |
not available |
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Parker EA, Israel BA, Brakefield-Caldwell W, Keeler GJ, Lewis TC, Ramirez E, et al. Community Action Against Asthma: Examining the partnership process of a community-based participatory research project. Journal of General Internal Medicine. 2003;18(7):558-567. |
R826710 (Final) |
not available |
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Parker EA, Robins TG, Israel BA, Brakefield-Caldwell W, Edgren KK, Wilkins D. Developing and implementing guidelines for dissemination: The experience of the Community Action Against Asthma project. In: BA Israel, E Eng, AJ Schulz and E Parker, editors. Methods in Community-Based Participatory Research for Health. San Francisco, CA: Jossey-Bass; 2005:285-306. |
R826710 (Final) |
not available |
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Parker EA, Baldwin GT, Israel BA. Health promotion models and theories for environmental health. Health Education & Behavior. 2004;31(4):491-509. |
R826710 (Final) |
not available |
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Trout D, Weissman DN, Lewis D, Brundage RA, Franzblau A, Remick D. Evaluation of hypersensitivity pneumonitis among workers exposed to metal removal fluids. Applied Occupational and Environmental Hygiene2003;18: 953-60. |
R826710 (Final) |
not available |
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Yip F, Keeler GJ, Dvonch JT, Robins T, Parker E, Israel BA, et al. Personal exposures to particulate matter among children with asthma in Detroit, Michigan. Atmospheric Environment. 2004;38:5227-5236. |
R826710 (Final) |
not available |
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Lewis TC, Robins TG, Joseph CLM, Parker EA, Israel BA, Rowe Z, et al. Identification of gaps in the diagnosis and treatment of childhood asthma using a community-based participatory research approach. Journal of Urban Health. 2004;81(3):472-488. |
R826710 (Final) |
not available |
HUMAN HEALTH, Air, Geographic Area, Scientific Discipline, Health, RFA, Molecular Biology/Genetics, Health Effects, Indoor Air Pollution, indoor air, Risk Assessments, Health Risk Assessment, Children's Health, Environmental Chemistry, Allergens/Asthma, State, exposure assessment, asthma indices, airborne urban contaminants, allergen, environmental tobacco smoke, inhalation, respiratory problems, respiratory disease, children's environmental health, asthmatic children, air quality, second hand smoke, cigarette smoke, assessment of exposure, childhood respiratory disease, human health risk, susceptibility, cockroaches, acute lung injury, air pollution, airborne pollutants, airway disease, children, exposure, children's vulnerablity, indoor air chemistry, asthma triggers, allergic response, asthma, human exposure, Human Health Risk Assessment, airway inflammation
Progress and Final Reports:
2000 Progress Report
2002 Progress Report
Final Report
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R826710C001 Indoor and Outdoor Air Contaminant Exposures and Asthma Aggravation Among Children (Asthma Exposure)
R826710C002 Chemokines in the Pathogenesis of Asthma (Asthma Chemokines)
R826710C003 A Community-Based Intervention to Reduce Environmental Triggers for Asthma Among Children (Asthma Intervention)