Projects

NEW AND EXPANDED USES OF OILSEED PRODUCTS AND BY-PRODUCTS Appropriated (D)   Accession Number: 408564

SCIENTIFIC EXCHANGE ON OILSEED AND OIL PROCESSING TECHNOLOGY Nonfunded Cooperative Agreement (N)   Accession Number: 411212

COTTONSEED PIGMENT GLAND SEPARATION, GOSSYPOL RECOVERY, AND GOSSYPOL CHEMISTRY Reimbursable (R)   Accession Number: 410473

DERIVATIZATION OF GOSSYPOL FOR VALUE-ADDED UTILIZATION Specific Cooperative Agreement (S)   Accession Number: 409904

Publications

Effect of Racemic, (+)- and (-)-Gossypol on the survival and development of the specialist Herbivore Heliothis virescens (Fabricius) - (Peer Reviewed Journal) - (23-Jun-08)

Structure of the anhydrous form of gossypol-Dianhydrogossypol - (Abstract)

Mamadrakhimov, A., Talipov, S.A., Tiljakov, Z.G., Dowd, M.K., Ibragimov, B.T. 2008. Structure of the anhydrous form of gossypol-Dianhydrogossypol (abstract). XXI Congress of the International Union of Crystallography. p. C395.

HPLC Preparation of the Chiral Forms of 6-Methoxy-Gossypol and 6,6'-Dimethoxy-Gossypol - (Peer Reviewed Journal)

Dowd, M.K., Pelitire, S.M. 2008. Hplc preparation of the chiral forms of 6-methoxy-gossypol and 6,6'-dimethoxy-gossypol. Journal of Chromatography B. 867:69-77.

Composition of Gossypol Enantiomers in Seeds of Uzbek Industrial Cotton Species - (Peer Reviewed Journal)

Mamadrakhimov, A.A., Tiljakov, Z.G., Talipov, S.A., Dowd, M.K., Ibragimov, B.T. 2008. Composition of Gossypol Enantiomers in Seeds of Uzbek Industrial Cotton Species. Journal of Uzbek Academy of Sciences. (3):69-72.

ASPERGILLUS FLAVUS HYDROLASES: THEIR ROLES IN PATHOGENESIS AND SUBSTRATE UTILIZATION - (Peer Reviewed Journal)

Mellon, J.E., Cotty, P.J., Dowd, M.K. 2007. Aspergillus flavus hydrolases: their roles in pathogenesis and substrate utilization. Applied Microbiology and Biotechnology. 77:497-504.

CRYSTAL AND MOLECULAR STRUCTURE OF 6,6´-DIMETHOXY-GOSSYPOL:ACETIC ACID (1:1) - (Peer Reviewed Journal)

Dowd, M.K., Stevens, E. 2007. Crystal and molecular structure of 6,6´-dimethoxy-gossypol:acetic acid (1:1). Journal of Chemical Crystallography. 37:765-770.

TRIMETHYLSILYL DERIVATIZATION/GAS CHROMATOGRAPHY AS A METHOD TO DETERMINE THE FREE FATTY ACID CONTENT OF VEGETABLE OILS - (Peer Reviewed Journal)

Wan, P.J., Dowd, M.K., Thomas, A.E., Butler, B.H. 2007. Trimethylsilyl derivatization/gas chromatography as a method to determine the free fatty acid content of vegetable oils. Journal of the American Oil Chemists' Society. 84:701-708.

The Role of Gossypol - (Review Article)

Dowd, M.K., Wakelyn, P.J., Wan, P.J., Wedegaertner, T.C. 2007. The Role of Gossypol. International News on Fats, Oils and Related Materials. 18(6):371.

Research on Value-Added uses for Cottonseed - (Review Article)

Wan, P.J., Dowd, M.K., Wakelyn, P.J., Wedegaertner, T.C. 2007. Research on Value-Added uses for Cottonseed. International News on Fats, Oils and Related Materials. 18(6):368-370,372.

Low Gossypol Doesn't Always Mean Low Yield and Low Quality - (Abstract) - (12-Jan-07)

RELATIVE TOXICITY OF GOSSYPOL ENANTIOMERS IN LAYERS AND BROILER BREEDER HENS - (Peer Reviewed Journal)

Lordelo, M.M., Calhoun, M.C., Dale, N.M., Dowd, M.K., Davis, A.J. 2007. Relative toxicity of gossypol enantiomers in layers and broiler breeder hens. Poultry Science. 86(3):582-590.

Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil. - (Peer Reviewed Journal)

Ye, W., Chang, H-L., Wang, L-S. Huang, Y-W., Shu, S., Dowd, M.K., Wan, P.J., Sugimoto, Y., Lin, Y. 2007. Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil. Anticancer Research. 27:107-116.

GOSSYPOL INHIBITS CALCINEURIN PHOSPHATASE ACTIVITY AT MULTIPLE SITES - (Peer Reviewed Journal)

Carruthers, N.J., Dowd, M.K., Stemmer, P.M. 2006. Gossypol inhibits calcineurin phosphatase activity at multiple sites. European Journal of Pharmacology. 555(2-3):106-114.

EFFECTS OF SERUM ON (-)-GOSSYPOL-SUPPRESSED GROWTH IN HUMAN PROSTATE CANCER CELLS - (Peer Reviewed Journal)

Huang, Y.W., Wang, L.S., Chang, H.L., Ye, W., Sugimoto, Y., Dowd, M.K., Wan, P.J., Lin, Y.C. 2007. Effects of serum on (-)-gossypol-suppressed growth in human prostate cancer cells. Anticancer Research Journal. 26(5A):3613-3620.

MOLECULAR MECHANISMS OF (-)-GOSSYPOL-INDUCED APOPTOSIS IN HUMAN PROSTATE CANCER CELLS - (Peer Reviewed Journal)

Huang, Y., Wang, L., Chang, H., Ye, W., Shu, S., Sugimoto, Y., Dowd, M.K., Wan, P.J., Lin, Y. 2006. Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells. Anticancer Research Journal. 26:1926-1934.

BIOSYNTHESIS AND REGULATION OF (+)-GOSSYPOL IN COTTONSEED AND UTILIZATION OF THE SEED - (Abstract)

Stipanovic, R.D., Liu, J., Puckhaber, L.S., Lopez, J., Dowd, M.K., Bell, A.A., Duke, S.E. 2006. Biosynthesis and regulation of (+)-gossypol in cottonseed and utilization of the seed [abstract]. Pacific Basin Society Chemical International Congress. Paper No. 402.

EFFECT OF RACEMIC AND (+)- AND (-)-GOSSYPOL ON THE SURVIVAL AND DEVELOPMENT OF HELICOVERPA ZEA LARVAE - (Peer Reviewed Journal)

Stipanovic, R.D., Lopez, J., Dowd, M.K., Puckhaber, L.S., Duke, S.E. 2006. Effect of racemic and (+)- and (-)-gossypol on the survival and development of Helicoverpa zea larvae. Journal of Chemical Ecology. 32(5):959-968.

CONFORMATIONAL ANALYSIS OF GOSSYPOL AND ITS DERIVATIVES BY MOLECULAR MECHANICS - (Peer Reviewed Journal)

Beisel, C.L., Dowd, M.K., Reilly, P.J. 2005. Conformational analysis of gossypol and its derivatives by molecular mechanics. Journal of Molecular Structure (Theochem). 730(1-3):51-58.

RELATIVE TOXICITY OF GOSSYPOL ENANTIOMERS IN BROILERS - (Peer Reviewed Journal)

Lordelo, M.M., Davis, A.J., Calhoun, M.C., Dowd, M.K., Dale, N.M. 2005. Relative toxicity of gossypol enantiomers in broilers. Poultry Science. 84(9):1376-1382.

SEPARATION AND PURIFICATION OF GOSSYPOL, 6-METHOXY-GOSSYPOL AND 6,6'-DIMETHOXY-GOSSYPOL FROM SEA ISLAND GOSSYPIUM BARBADENSE - (Abstract)

Dowd, M.K., Pelitire, S.M. 2005. Separation and purification of gossypol, 6-methoxy-gossypol and 6,6'-dimethoxy-gossypol from sea island gossypium barbadense (abstract). Book of Abstracts, 2005 96th American Oil Chemists' Society Meeting, May 1-4, Salt Lake City, UT. p. 98-99.

CRYSTAL AND MOLECULAR STRUCTURES OF GOSSYPOL-CYCLOHEPTANONE (1:2) AND GOSSYPOL-CYCLOOCTANONE (1:2) - (Abstract)

Dowd, M.K., Stevens, E.D. 2005. Crystal and molecular structures of gossypol-cycloheptanone (1:2) and gossypol-cyclooctanone (1:2) (abstract). 2005 229th American Chemical Society National Meeting, March 13-17, 2005, San Diego, CA. p. 67.

COTTONSEED EXTRACTION WITH MIXTURES OF ACETONE AND HEXANE - (Peer Reviewed Journal)

Kuk, M.S., Tetlow, R., Dowd, M.K. 2005. Cottonseed extraction with mixtures of acetone and hexane. Journal of the American Oil Chemists' Society. 82(8):609-612.

OPTIMAL GROWTH AND SECONDARY METABOLITE PRODUCTION FROM COTTON HAIRY ROOTS - (Abstract)

Dowd, M.K., Moss, S.C., Pelitre, S.M., Triplett, B.A. 2005. Optimal growth and secondary metabolite production from cotton hairy roots. Proc. Beltwide Cotton Conf., New Orleans, LA, p. 2122. http://www.cotton.org/beltwide/proceedings/2005/pdfs/3027.pdf

OPTIMAL GROWTH AND SECONDARY METABOLITE PRODUCTION FROM COTTON HAIRY ROOTS - (Abstract)

Dowd, M.K., Moss, S.C., Pelitire, S.M., Triplett, B.A. Optimal growth and secondary metabolity production from cotton hairy roots. 2005 Beltwide Cotton Conference, January 4-7, New Orleans, LA . p. 2122.

CULTURE PARAMETERS INFLUENCING THE PRODUCTION OF GOSSYPOL AND RELATED COMPOUNDS IN COTTON HAIRY ROOTS - (Abstract)

Moss, S.C., Dowd, M.K., Pelitre, S.M., Triplett, B.A. 2005. Culture parameters influencing the production of gossypol and related compounds in cotton hairy roots. In Vitro Biology-2005. poster-2023, p. 40-A. http://www.sivb.org/2005A_p1.pdf

INITIATION AND PROLIFERATION OF GOSSYPOL-PRODUCING COTTON HAIRY ROOTS - (Abstract)

Moss, S.C., Dowd, M.K., Triplett, B.A. 2005. Initiation and proliferation of gossypol-producing cotton hairy roots. Proc. Beltwide Cotton Conf., New Orleans, LA, p. 2092. http://www.cotton.org/beltwide/proceedings/2005/pdfs/2825.pdf

SUBSTRATE UTILIZATION BY ASPERGILLUS FLAVUS IN INOCULATED WHOLE CORN KERNELS AND ISOLATED SEED TISSUES - (Peer Reviewed Journal)

Mellon, J.E., Dowd, M.K., Cotty, P.J. 2005. Substrate utilization by Aspergillus flavus in inoculated whole corn kernels and isolated tissues. Journal of Agricultural and Food Chemistry. 53(6):2351-2357.

INCLUSION COMPLEXES OF GOSSYPOL WITH 2-PENTANONE, 3-PENTANONE AND 2-HEXANONE - (Peer Reviewed Journal)

Dowd, M.K., Stevens, E.D. 2005. Inclusion complexes of gossypol with 2-pentanone, 3-pentanone and 2-hexanone. Journal of Inclusion Phenomena and Macrocyclic Chemistry. 51(1):65-71.

THE (-)-GOSSYPOL-2,4-PENTANEDIONE (1:2) INCLUSION COMPLEX - (Peer Reviewed Journal)

Dowd, M.K., Stevens, E.D. 2004. The (-)-gossypol-2,4-pentanedione (1:2) inclusion complex. Journal of Chemical Crystallography. 34(8):559-564

CYTOTOXICITY OF ENANTIOMERS OF GOSSYPOL SCHIFF'S BASES AND OPTICAL STABILITY OF GOSSYPOLONE - (Peer Reviewed Journal)

Dao, V-T., Dowd, M.K., Martin, M-T., Gaspard, C., Mayer, M., Michelot, R.J. 2004. Cytotoxicity of enantiomers of gossypol schiff's bases and optical stability of gossypolone. European Journal of Medicinal Chemistry. 39(7):619-624.

INITIATION AND PROLIFERATION OF COTTON HAIRY ROOTS - (Abstract)

Moss, S.C., Triplett, B.A., Dowd, M.K. Initiation and proliferation of cotton hairy roots. Congress for In-Vitro Biology. 2004. p. 53A.

EXTRACTION, RECOVERY, AND STABILITY OF CAROTENOIDS FROM CORN GLUTEN MEAL - (Abstract)

Dowd, M.K., Pelitire, S.M. 2004. Extraction, recovery, and stability of carotenoids from corn gluten meal. Meeting Abstract.

THE INCLUSION COMPLEX OF (-)-GOSSYPOL WITH 2,4-PENTANEDIONE - (Abstract)

Dowd, M.K., Stevens, E.D. 2004. The inclusion complex of (-)-gossypol with 2,4-pentanedione (abstract}. American Oil Chemists' Society. p.123

EFFECT OF EXTRACTION SOLVENTS ON COMPOSITION OF OIL AND MEAL OBTAINED FROM COTTONSEED - (Abstract)

Wan, P.J., Waggoner, A.E., Dowd, M.K. 2004. Effect of extraction solvents on composition of oil and meal obtained from cottonseed (abstract). American Oil Chemists' Society. p. 123-124.

NEW POSSIBILITIES FOR SOME OLD GENES: IMPROVED HOST PLANT RESISTANCE IN COTTON - (Proceedings/Symposium)

Scheffler, J.A., Dowd, M.K., Meredith Jr, W.R., Scheffler, B.E. 2004. New possibilities for some old genes: improved host plant resistance in cotton. In: Proceedings of the World Cotton Research Conference III, March 9-13, 2003, Cape Town, South Africa. p. 175-182.

THE GOSSYPOL-CYCLODODECANONE (1/2) INCLUSION COMPLEX - (Peer Reviewed Journal)

Dowd, M.K., Stevens, E.D. 2003. The gossypol-cyclododecanone (1/2) inclusion complex. Acta Crystallographica Section C: Crystal Structure Communications. 59(7):0397-0399

IMPROVEMENTS TO LABORATORY-SCALE MAIZE WET-MILLING PROCEDURES - (Peer Reviewed Journal)

Dowd, M.K. 2003. Modifications to laboratory-scale (100-g) maize wet-milling procedures. Industrial Crops and Products. 18(1):67-76.

PREPARATION OF ENANTIOMERIC GOSSYPOL BY CRYSTALLIZATION - (Peer Reviewed Journal)

Dowd, M.K. 2003. Preparation of enantiomeric gossypol by crystallization. Chirality. 15(6):486-493.

NEW THIODERIVATIVES OF GOSSYPOL AND GOSSYPOLONE, AS PRODRUGS OF CYTOTOXIC AGENTS - (Peer Reviewed Journal)

Dao, V., Dowd, M.K., Gaspard, C., Martin, M., Hemez, J., Laprevote, O., Mayer, M., Michelot, R. 2003. New thioderivatives of gossypol and gossypolone, as prodrugs of cytotoxic agents. Bioorganic and Medicinal Chemistry. 11(9):2001-2006.

EFFECTS OF OPTICALLY ACTIVE GOSSYPOL ON CONIDIA GERMINATION AND GROWTH OF ASPERGILLUS FLAVUS - (Proceedings/Symposium)

Mellon, J.E., Cotty, P.J., Dowd, M.K. 2003. Effects of optically active gossypol on conidia germination and growth of Aspergillus flavus. Proceedings of National Cotton Council Beltwide Cotton Conference. p. A29-A32.

EFFECTS OF OPTICALLY ACTIVE GOSSYPOL ON GROWTH PARAMETERS OF ASPERGILLUS FLAVUS - (Abstract)

Mellon, J.E., Cotty, P.J., Dowd, M.K. 2002. Effects of optically active gossypol on growth parameters of aspergillus flavus [abstract]. Proceedings of the American Society of Plant Biologists Meeting, Plant Biology. p. 190.