Recent Additions

29 December 2006

Notice of the release of the Toxicological Review for 2,2,4-Trimethylpentane and notice of the External Peer Review Panel Meeting.
The EPA is announcing a public comment period and an external peer review panel meeting to review the draft document titled,'Toxicological Review of 2,2,4-Trimethylpentane: In Support of Summary Information on the Integrated Risk Information System (IRIS)' (NCEA-S-2202), related to the human health assessment for 2,2,4- trimethylpentane. [Federal Register Notice December 29, 2006]

22 December 2006

IRIS Update: Request for Chemical Substance nominations for the IRIS 2007 program agenda
EPA is soliciting public nominations for substances for its 2007 agenda. EPA invites the public to submit nominations for substances to be considered for an assessment or reassessment in its IRIS Program. Nominations must be submitted within 30 days of the publication of this notice. The 30-day period begins December 22, 2006 and ends January 22, 2007. [Federal Register: December 22, 2006 (Volume 71, Number 246)]

22 December 2006

External Peer Review Panel Meeting on IRIS Toxicological Review Documents for Polybrominated Diphenyl Ethers.
EPA's IRIS Program is announcing that an external peer review panel meeting to review the draft documents entitled, "Toxicological Review of TetraBDE (BDE-47): In Support of Summary Information in the Integrated Risk Information System (IRIS)" (NCEA-S-2537); "Toxicological Review of PentaBDE (BDE-99): In Support of Summary Information in the Integrated Risk Information System (IRIS)" (NCEA-S-2538); "Toxicological Review of HexaBDE (BDE-153): In Support of Summary Information in the Integrated Risk Information System (IRIS)" (NCEA-S-2539); and "Toxicological Review of DecaBDE (BDE-209): In Support of Summary Information in the Integrated Risk Information System (IRIS)" (NCEA-S-2540). The documents were published in the Federal Register December 22, 2006 [FR Notice: Volume 71, Number 246; FDMS Docket ID: EPA-HQ-ORD-2006-0838].

20 December 2006

IRIS Updates: Final Report on the External Peer Review for the IRIS Assessment of 1,4-Dichlorobenzene
This document is the final report for the 2006 external peer review for the IRIS Assessment of 1,4-Dichlorobenzene (inhalation cancer assessment and RfC), prepared by the U.S. Environmental Protection Agency (EPA), National Center for Environmental Assessment (NCEA), for the Integrated Risk Information System (IRIS). A panel of external peer reviewers met to discuss their responses to the charge questions on November 3, 2006. This document contains the final written comments of the external peer reviewers.

12 October 2006

IRIS Updates: Dichlorobenzenes and Ethylene Oxide
EPA is releasing by Federal Register Notices two new IRIS Reviews: the Toxicological Review of Dichlorobenzenes: In Support of Summary Information on the Integrated Risk Information System (IRIS) [FR Notice], and the Evaluation of the Carcinogenicity of Ethylene Oxide [FR Notice].

28 September 2006

IRIS Literature Screening Verification
As part of the FR notice (69 FR 5971) issued on February 9, 2004, announcing the annual IRIS agenda, EPA stated that it would use findings from the recent IRIS literature screening level review project as the basis for a systematic update of the IRIS database. The purpose of EPA's screening level review was to reach a preliminary determination regarding the need for a full reassessment. That determination was needed based on an evaluation of new health effects literature that could potentially result in significant changes to existing toxicity values or cancer weight-of-evidence designations. The FR notice stated that EPA would begin performing more in-depth reviews of the extant health literature to confirm results from the literature screening. The IRIS summaries have been updated to confirm that existing assessments are current for the substances that were found to be without significant new health effects information that could result in a change to the existing data in IRIS. Also, the FR notice requested submission of scientific information from the public to confirm the results of the literature screening review. Confirmatory statements were added on September 19, 2004, June 22, 2005, August 15, 2005 and July 5, 2006 to a total of 56 IRIS Summaries. Since then, another 10 confirmations have been completed for 3,3'-dichlorobenzidine, p-bromodiphenyl ether, tribromochloromethane, benzotrichloride, brominated dibenzofurans, 4,4'-methylene bis(N,N'-dimethyl)aniline, bromate, quinoline, diethyl-p-nitrophenylphosphate, and 1,1,1,2-tetrachloroethane. These confirmations will be added to the IRIS Summaries on 09/28/2006. The results of the screening project were added to the IRIS database beginning in 2003 and continue as an ongoing project.

27 September 2006

Release for Public Review of the Health Assessment Document for the Carcinogenicity of Ethylene Oxide
EPA's IRIS Program is announcing that a 30-day public comment period for the draft document titled, ''Evaluation of the Carcinogenicity of Ethylene Oxide'' (EPA/635/R-06/003) was published in the Federal Register (09/22/2006) [E-docket No.: EPA-HQ-ORD 2006- 0756]

18 August 2006

Final Report on the External Peer Review for the IRIS Reassessment of Dibutyl Phthalate
This document is the final report for the 2006 external peer review for the IRIS Reassessment of Dibutyl Phthalate, prepared by the U.S. Environmental Protection Agency (EPA), National Center for Environmental Assessment (NCEA), for the Integrated Risk Information System (IRIS). A panel of external peer reviewers met to discuss their responses to the charge questions on July 28, 2006. This document contains the final written comments of the external peer reviewers.

11 August 2006

Notice of the External Peer Review Panel Meeting on the Toxicological Review for 1,4-Dichlorobenzene
EPA's IRIS Program is announcing that an extension of the public comment period and rescheduling of the external peer review panel teleconference to review the draft document entitled, "Toxicological Review of Dichlorobenzenes: In Support of Summary Information on the Integrated Risk Information System (IRIS)" (EPA/635/R-03/015), was published in the Federal Register on August 11, 2006 [FDMS Docket ID: EPA-HQ-ORD-2004-0002].

13 July 2006

Notice of the External Peer Review Panel Meeting on the Toxicological Review for 1,4-Dichlorobenzene
EPA's IRIS Program is announcing that an external peer review panel meeting to review the draft document entitled, "Toxicological Review of Dichlorobenzenes: In Support of Summary Information on the Integrated Risk Information System (IRIS)" was published in the Federal Register July 11, 2006 [FDMS Docket ID: EPA-HQ-ORD-2004-0002].

05 July 2006

IRIS Literature Screen Verification
The IRIS Program has added statements to certain existing IRIS Summaries confirming that the health effects information upon which the assessment was based is still current. This is to follow up on our February 9, 2004 FR notice (69 FR 5971) announcing the annual IRIS agenda. In that notice, EPA announced that we would use findings from our recent IRIS literature screening project (the results of which were added to IRIS beginning in 2003) as the basis for a systematic update of the IRIS database. We explained that we would begin performing a more in-depth review of the extant health literature to confirm results from the literature screen. For those substances confirmed to be without new health effects information likely to change an existing assessment, we stated that we would update IRIS Summaries to indicate this finding. Also, in the FR notice we sought submission of scientific information from the public to confirm the results of the literature screen review. Confirmatory statements were added on September 19, 2004, June 22, 2005, and August 15, 2005 to a total of 48 IRIS Summaries. Confirmatory statements for 8 additional substances have been added to IRIS Summaries for methyl methacrylate, nickel refinery dust, 1,2-diphenylhydrazine, tetrachlorocyclopentadiene, trichlorocyclopentadiene, ammonium methacrylate, chlorocyclopentadiene, and t-butylchloride on 07/05/2006. This will be an on-going project.

27 June 2006

Notice of the External Peer Review Panel Meeting on the Toxicological Review for Dibutyl Phthalate
EPA's IRIS Program is announcing that an external peer review panel meeting to review the draft document entitled, "Toxicological Review of Dibutyl Phthalate (Di-n-Butyl Phthalate): In Support of Summary Information on the Integrated Risk Information System (IRIS)" (NCEA-S-1755) was published in the Federal Register June 27, 2006 [FDMS Docket ID: EPA-HQ-ORD-2006-0500].

22 May 2006

IRIS: 2006 Corrected Program Agenda Announced
EPA's announcement of the IRIS 2006 program agenda, with a corrected list of substances, and request for scientific information on human health effects that may result from exposure to substances was published in the May 19, 2006 Federal Register Notice (PDF) (4 pp, 64KB)

31 January 2006

The Summary of Phosgene has been revised and an updated Toxicological Review (PDF) (102 pp, 614KB) has been added to the IRIS Web site.

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