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Research Project:
CONTROL OF PLANT-PARASITIC NEMATODES BY INTERFERENCE WITH INTERNAL TARGETS
Location: Nematology Laboratory
Project Number: 1275-22000-247-00
Project Type:
Appropriated
Start Date: Feb 27, 2007
End Date: Feb 26, 2012
Objective:
1) Discover nematode proteins and peptides that regulate development, growth and survival, and that provide new targets for controlling nematodes; and 2) Disrupt the function of steroid- or lipid-based regulatory systems unique to plant-parasitic nematodes and critical for their life processes.
Approach:
1) Identify proteases and peptides that control hatching or molting in soybean cyst nematode and root-knot nematode and evaluate specific molecular inhibitors; and identify regulatory proteins, including membrane receptors, involved in the nematode response to its environment and plant host; and 2) Isolate and identify lipids and steroids with likely regulatory roles in plant-parasitic nematodes, and elucidate the biochemical pathways involved in the biosynthesis and metabolism of these compounds; and develop rational strategies for nematode management based upon the utilization of knowledge about the endogenous bioregulatory lipids or steroids in phytoparasitic nematodes.
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Last Modified: 11/07/2008
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