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The Virtual Embryo Project (v-Embryo™):
A computational framework for developmental toxicity

Overview

Prenatal development may be perturbed by agents that a pregnant mother is exposed to. The Virtual Embryo Project (v-Embryo™) is a far reaching new research program at EPA to develop a sophisticated computer model of a mammalian embryo that can be used to better understand the prenatal risks posed by environmental chemicals and to ultimately predict a chemical’s potential developmental toxicity in silico.

The basic concept of v-Embryo™ is a public portal, knowlegebase, and computational infrastructure for modeling genetic-cellular networks and developmental toxicity pathways. Affiliated computational techniques fall into two general areas of knowledge-discovery and computer simulation. As such, the project aligns with other systems biology research initiatives at the National Center for Computational Toxicology (NCCT) including ACToR, ToxCast™, and Virtual Liver.












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