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ACToR Home
ACToR will be live later in 2008 – please check back later
ACToR (Aggregated Computational Toxicology Resource) is a collection of databases collated or developed by the US EPA National Center for Computational Toxicology (NCCT). More than 200 sources of publicly available data on environmental chemicals have been brought together and made searchable by chemical name and other identifiers, and by chemical structure. Data includes chemical structure, physico-chemical values, in vitro assay data and in vivo toxicology data. Chemicals include, but are not limited to, high and medium production volume industrial chemicals, pesticides (active and inert ingredients), and potential ground and drinking water contaminants.
At present, data on environmental chemicals resides in a variety of specialized databases, in many different and incompatible formats and in many different locations. Up to now, in order to compile all information on a given chemical, one needed to search multiple databases and then manually compile the resulting data. While this is possible to do for specific chemicals, it is very difficult to compile comprehensive data sets on chemically-similar sets of compounds using structure searching tools. By bringing together data from a large number of sources and making the data structure-searchable, ACToR will facilitate searches that transcend available data and chemical number. As such, it will be an important tool for the advancement of computational toxicology, which requires evaluation of information across broad scales of chemical class, use, structure and biological activity.
The ACToR project is compiling data (both quantitative and qualitative) from a large number of sources (called data collections), including EPA databases, PubChem, other NIH and FDA databases, state and other national sources, and from academic groups. One novel data collection is ToxRefDB, which includes detailed information on in vivo guideline study results for pesticides and other potentially toxic chemicals that has been assembled by the National Center of Computational Toxicology. ACToR is also the primary repository of data being produced by the EPA ToxCast chemical screening prioritization program.
The majority of chemicals in ACToR have chemical structures, which will facilitate studies of structure-function relationships in sets of environmental chemicals. The DSSTox Program in the NCCT is responsible for structure annotation in ACToR.
Adding new data into ACToR is straightforward. We are always interested in obtaining other data collections that could be incorporated into the system.