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Study to Investigate the Effects of Hot Drinks on Nasal Airway Resistance and Symptoms of Common Cold
This study has been completed.
Study NCT00495976   Information provided by Cardiff University
First Received: July 2, 2007   Last Updated: March 21, 2008   History of Changes
This Tabular View shows the required WHO registration data elements as marked by

July 2, 2007
March 21, 2008
September 2007
Change in nasal conductance of airflow from before the drink to immediately after the drink [ Time Frame: prospective ]
Same as current
Complete list of historical versions of study NCT00495976 on ClinicalTrials.gov Archive Site
Exploratory analysis will also be made to investigate the relationship between objective measures of nasal airflow and the symptoms of common cold. [ Time Frame: prospective ]
Same as current
 
Study to Investigate the Effects of Hot Drinks on Nasal Airway Resistance and Symptoms of Common Cold
A Pilot Study to Investigate the Effects of Hot Drinks on Nasal Airway Resistance and Symptoms of Common Cold

Common cold medicines are often formulated as a hot drink yet there is no evidence in the public domain that presenting the medicine as a hot drink has any impact on symptom severity.

Common cold medicines are often formulated as a hot drink and usually contain paracetamol and a decongestant such as phenylephrine but it is the 'hot drink' formulation that is often an attraction to the patient in deciding on which formulation of a cold medicine to purchase and use. Hot drinks have been used to relieve the symptoms of acute respiratory infections such as colds and flu for hundreds of years and are found in the traditional medicines of countries throughout the world. The idea of using a hot drink to treat colds and flu appears to originate from a perceived link between exposure to cold and chilling and the onset of a respiratory infection. In order to combat the cold exposure many traditional remedies use a warming and soothing drink or application of a warming ointment . Despite the widespread folklore that hot drinks are an effective treatment for colds and flu, and the use of hot drink formulations for many current common cold medicines, there appears to be no evidence base in the medical literature supporting the efficacy of this common treatment for common cold. The aim of the present study is to obtain new knowledge about the effects of hot drinks on nasal airway resistance and other symptoms of common cold.

 
Interventional
Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study
Common Cold/Flu
Other: A commercially produced cordial drink
 
 

*   Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
 
Completed
60
October 2007
October 2007   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Aged over 18 years.
  • Has given informed consent.
  • Is suffering from common cold/flu like illness
  • Indicates they are suffering from at least three common cold symptoms (runny nose, sneezing, blocked nose, sore throat, cough) and scores at least 2 symptoms as moderate on four point ordinal scale of (0=not present, 1=mild, 2=moderate, 3=severe)

Exclusion Criteria:

Subjects will not be enrolled in the study if any of the following criteria are met:

  • The subject is unwilling to sign the consent form.
  • The subject has a clinically significant cardiovascular, endocrinological, neurological, respiratory, gastrointestinal disease or any other disease that is considered by the investigator as a reason for exclusion.
  • The subject has a severe nasal septal deviation or other condition that could cause nasal obstruction such as the presence of nasal polyps.
  • The subject has had nasal surgery in the past that in the opinion of the investigator may influence symptom scores or nasal airway resistance
  • The subject has ingested any alcohol within the previous 12 hours or more than 4 units of alcohol in the previous 24 hours
  • The subject is a drug or alcohol abuser
  • The subject is taking any prescribed medication other than for contraception
  • The subject has had common cold for more than 7 days
  • The subject has recently taken a common cold medicine that in the opinion of the investigator may influence symptom scores or nasal airway resistance (analgesics, nasal decongestants, cough medicines)
  • The subject has ingested any hot food or drink within the previous hour
Both
18 Years and older
Yes
 
United Kingdom
 
 
NCT00495976
Professor Ron Eccles, Cardiff University
 
Cardiff University
 
Principal Investigator: Ron Eccles, D.Sc Common Cold Centre and Healthcare Clinical Trials, Cardiff University, UK
Cardiff University
November 2007

 †    Required WHO trial registration data element.
††   WHO trial registration data element that is required only if it exists.