Project Number: 1265-31000-091-06
Project Type: Reimbursable

Start Date: Sep 17, 2008
End Date: Mar 31, 2012

Objective:
To test the ability of triple fusion peptidoglycan hydrolases to eradicate S. aureus in a rodent model of nasal colonization.

Approach:
Triple fusion antimicrobials will be created and tested for three lytic activities, the effect of surface structures to effect susceptibility of S. aureus to the fusion peptidoglycan hydrolases, and finally the triple fusion proteins are tested for their ability to eradicate nasally colonized S. aureus.