Projects

EFFICIENCY OF NUTRIENT USE IN CATTLE:IDENTIFICATION OF CRITICAL PHYSIOLOGIC AND GENOMIC REGULATORY PATHWAYS Appropriated (D)   Accession Number: 412344

Publications

Butyrate Induced Cell Cycle Arrest in Bovine Cells through Targeting Gene Expression relevance to DNA Replication Apparatus - (Peer Reviewed Journal)

Li, C., Li, R.W. 2008. Butyrate Induced Cell Cycle Arrest in Bovine Cells through Targeting Gene Expression relevance to DNA Replication Apparatus. Gene Regulation and Systems Biology. 2:113-123.

Effects of butyrate on the expression of insulin-like growth factor binding proteins in bovine kidney epithelial cells - (Peer Reviewed Journal)

Li, R.W., Li, C. 2008. Effects of butyrate on the expression of insulin-like growth factor binding proteins in bovine kidney epithelial cells. The Open Veterinary Science Journal. 2:1-6.

EPIGENETIC REGULATION OF GENOMES: NUTRIENT-SPECIFIC MODULATION OF GENETIC NETWORKS IN BOVINE CELLS - (Proceedings/Symposium)

Li, C., Elsasser, T.H., Li, R.W. 2008. Epigenetic regulation of genomes: nutrient-specific modulation of genetic networks in bovine cells. Animal Genetics International Conference Proceedings. 132:391-398.

Epigenetic regulation of genomes: Nutrient-specific modulation of genetic networks in bovine cells - (Abstract)

Li, C.-L, Elsasser, T.H., Li, R.W. 2007 Epigenetic regulation of genomes: nutrient-specific modulation of genetic networks in bovine cells [abstract]. International Symposium on Anima Genomics for Animal Health, Paris, France, October 23-25, 2007.

Epigenetic mechanisms at work: Exploiting nutrient-specific modulation of genetic networks - (Abstract)

Li, C.-J, Elsasser, T.H., Li, R.W. 2007. Epigenetic mechanisms at work: Exploiting nutrient-specific modulation of genetic networks [abstract]. 29th General Assembly of the International Union of Biological Sciences and Scientific Symposium. Proceedings p7, Washington, DC.

Nitration of JAK-2 at the 1007Y-1008Y activation epitope impedes phosphorylation at this site: defining a GH, AKT/protein kinase B and nitric oxide synthase axis - (Peer Reviewed Journal)

Elsasser, T.H., Li, C., Caperna, T.J., Kahl, S., Schmidt, W.F. 2007. GH-associated nitration of JAK2 at the 1007Y-1008Y epitope impedes phosphorylation at this site: Mechanism for and impact of a GH, AKT and nitric oxide synthase (NOS) axis on GH signal transduction. Endocrinology. 148:3792-3802. Available: http://endo.endojournals.org.

CAVEOLAE-BASED NITRATION AT THE JAK-2 KINASE 1007 Y-1008-Y PHOSPHORYLATION SITE; A NOVEL REGULATORY INPUT TO SIGNAL TRANSDUCTION PROCESSING - (Peer Reviewed Journal)

Elsasser, T.H., Kahl, S., Li, C., Sartin, J.L., Garrett, W.M., Rodrigo, J. 2007. Caveolae-based nitration at the jak-2 kinase 1007 y-1008-y phosphorylation site; a novel regulatory input to signal transduction processing. Endocrinology 148:3803-3813. Available http://endo.endojournals.org.

Pathways analysis identifies perturbation of genetic networks induced by butyrate in a bovine kidney epithelial cell line - (Peer Reviewed Journal)

Li, C.J., Li, R.W., Wang, Y.H. Elsasser, T.H. 2007. Pathway analysis identifies perturbation of genetic networks induced by butyrate in a bovine kidney epithelial cell line. Functional and Integrative Genomics. 7:193-205.

SPECIFIC CELL CYCLE SYNCHRONIZATION WITH BUTYRATE AND CELL CYCLE ANALYSIS BY FLOW CYTOMETRY FOR MADIN DARBY BOVINE KIDNEY (MDBK) CELL LINE - (Peer Reviewed Journal)

Li, C., Elsasser, T.H. 2006. Specific cell cycle synchronization with butyrate and cell cycle analysis by flow cytometry for Madin Darby Bovine Kidney (MDBK) cell line. Journal of Animal and Veterinary Advances. 5(11):916-923.

GROWTH HORMONE (GH) DIRECTS NITRATION OF THE TYROSINE PHOSPHORYLATION SITE OF THE JAK-2 (1007-1008Y) IN HEPATOCYTES THROUGH AN AKT/PHOSPHORYLASE KINASE B ACTIVATION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE (ENOS) - (Abstract)

Elsasser, T.H., Caperna, R.J., Li, C., Kahl, S. 2006. Growth hormone (GH) directs nitration of the tyrosine phosphorylation site of JAK-2 (1007-1008Y) in hepatocytes through an AKT/Phosphorylase Kinase B activation of endothelial nitric oxide synthase (eNOS) [abstract]. Proceedings of the Annual Meeting of the Endocrine Society. p. 44.

THE IGF SYSTEM IN CHICKENS: FACTORS AFFECTING GENE EXPRESSION IN MUSCLE AND LIVER - (Abstract)

Kuo, A., Clover, C.M., Rosebrough, R.W., McMurtry, J.P., Mitchell, A.D., Caperna, T.J., Li, C., Kahl, S., Elsasser, T.H. 2006. The IGF system in chickens: Factors affecting gene expression in muscle and liver [abstract]. Journal of Federation of American Societies for Experimental Biology. 20:A172.

SODIUM BUTYRATE INDUCED GENE EXPRESSION CHANGES IN THE MADIN-DARBY BOVINE KIDNEY EPITHELIAL CELLS - (Other)

Li, R.W., Li, C. 2006. Sodium butyrate induced gene expression changes in the madin-darby bovine kidney epithelial cells [abstract]. Gene expression Omnibus. GSE 3970.

TEMPORAL RESPONSE OF SIGNAL TRANSDUCTION ELEMENTS DURING ENDOTOXIN CHALLENGE IN CATTLE LIVER: EFFECTS OF GROWTH HORMONE TREATMENT - (Peer Reviewed Journal)

Li, C.J., Kahl, S., Carbaugh, D., Elsasser, T.H. 2006. Temporal response of signal transduction elements during endotoxin challenge in cattle liver cells: Effects of growth hormone treatment. Domestic Animal Endocrinology 32(2):79-92.

GROWTH HORMONE EFFECTS IN IMMUNE STRESS: AKT/ENOS SIGNALING MODULE IN THE CELLULAR RESPONSE - (Abstract)

Li, C., Elsasser, T.H. 2006. Growth hormone effects in immune stress: AKT/ENOS signaling module in the cellular response [abstract]. Keystone Symposia, Signaling Networks. Abstract Book p.43.

TUMOR NECROSIS FACTOR-A (TNF-A) MODULATE INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN (IGFBPS) ACTIVITY FROM CULTURED EPITHELIAL VIA IGFBP-3 PROTEASE ACTIVITY - (Abstract)

Elsasser, T.H., Sartin, J.L., Li, C., Kahl, S. 2005. Tumor necrosis factor-a decreases media content of epithelial cell-derived insulin-like growth factor binding proteins (IGFBP) in part through increased proteolytic degradation of IGFBP-3 [abstract]. Journal of Animal Science. 83(Suppl.1):209.

TEMPORAL RESPONSE OF SIGNAL TRANSDUCTION ELEMENTS DURING ENDOTOXIN CHALLENGE IN CATTLE LIVER CELLS: EFFECTS OF GROWTH HORMONE TREATMENT - (Abstract)

Li, C., Elsasser, T.H., Kahl, S., Carbaugh, D. 2005. Temporal response of signal transduction elements during endotoxin (LPS) challenge in cattle liver cells: Effects of growth hormone treatment [abstract]. Journal of Animal Science. 83(suppl 1):8.

HYPER-RESPONSIVENESS TO PROINFLAMMATORY CHALLENGE INTENSIFIES METABOLIC IMPAIRMENT: ASSOCIATIONS BETWEEN INCREASED 1007Y-1008Y JAK-2 NITRATION AND DECREASED IGF-1 AND IGF-1 MRNA EXPRESSION - (Abstract)

Elsasser, T.H., Garrett, W., Kahl, S., Schmidt, W., Li, C. 2005. Hyper-responsiveness to proinflammatory challenge intensifies metabolic impairment: associations between increased 1007-Y-1008Y JAK-2 nitration and decreased IGF-1 and IGF-1 mRNA expression [abstract]. Proceedings of the Endocrine Society, 87th Annual Meeting. p.391.

UBIQUITIN-PROTEASOME PATHWAY IS INVOLVED IN BUTYRATE-INDUCED APOPTOSIS AND CELL CYCLE ARREST IN BOVINE KIDNEY EPITHELIAL CELLS - (Abstract)

Li, C.J., Elsasser, T.H. 2005. Ubiquitin-proteasome pathway is involved in butyrate-induced apoptosis and cell cycle arrest in bovine kidney epithelial cells [abstract]. Keystone Symposia, Ubiquitin and Signaling. Abstract Book. p55.

BUTYRATE-INDUCED APOPTOSIS AND CELL CYCLE ARREST IN BOVINE KIDNEY EPITHELIAL CELLS: INVOLVEMENT OF CASPASE AND PROTEASOME PATHWAYS - (Peer Reviewed Journal)

Li, C.J., Elsasser, T.H. 2005. Butyrate-induced apoptosis and cell cycle arrest in bovine kidney epithelial cells: involvement of caspase and proteasome pathways. Journal of Animal Science. 83:89-97.

PROTEIN TYROSINE NITRATION: A MEMBRANE-ORGANIZED MECHANISM FOR ALTERED SIGNAL TRANSDUCTION DURING PROINFLAMMATORY STRESS - (Abstract)

Elsasser, T.H., Kahl, S., Sartin, J.L., Li, C. 2004. Protein tyrosine nitration: a membrane organized mechanism for altered signal transduction during proinflammatory stress [abstract]. Journal of Animal Science 82 (Suppl.1):445.

BUTYRATE-INDUCED APOPTOSIS AND CELL CYCLE ARREST IN BOVINE KIDNEY EPITHELIAL CELLS: INVOLVEMENT OF CASPASE AND PROTEASOME PATHWAYS - (Abstract)

Li, C., Elsasser, T. 2004. Butyrate-induced apoptosis and cell cycle arrest in bovine kidney epithelial cells: involvement of caspase and proteasome pathways [abstract]. BARC Poster Day.

GROWTH HORMONE ADMINISTRATION PROMOTES A TEMPORALLY-DEFINED LOW-LEVEL NITRATION OF THE Y1007-Y1008 ACTIVATION SITE OF JAK-2 KINASE INVIVO AND IN VITRO - (Abstract)

Elsasser, T.H., Kahl, S., Li, C., Wilkins, B. 2004. Growth hormone administration promotes a temporally-defined low-level nitration of the Y1007-Y1008 activation site of JAK-2 kinase in vivo and invitro [abstract]. Endocrine Society Program and Abstracts. p. 245.

RESPONSE OF INDUCIBLE-TYPE NITRIC OXIDE SYNTHASE AND CYTOKINES IN BOVINE PERIPHERAL BLOOD MONONUCLEAR CELLS UPON ACTIVATION BY BACTERIAL ENDOTOXINS - (Abstract)

Li, C., Carbaugh, D., Kahl, S., Elsasser, T.H. 2004. Concomitant dual wavelength fluorescence evaluation of inducible nitric oxide synthase and cytokine responses to endotoxin stimulation of peripheral blood mononuclear cells [abstract]. Journal of Animal Science 82(Suppl.1):180.

ROLE FOR CDK1 (CDC2)/CYCLIN A IN PREVENTING THE MAMMALIAN ORIGIN RECOGNITION COMPLEX'S LARGEST SUBUNIT (ORC1) FROM BINDING TO CHROMATIN DURING MITOSIS - (Peer Reviewed Journal)

Li, C., Vassilev, A., DePamphilis, M.L. 2004. Role for Cdk1 (Cdc2)/Cyclin A in preventing the mammalian origin recognition complex's largest subunit (Orc1) from binding to chromatin during mitosis. Molecular and Cellular Biology. 24(13) p.5875-5886.

MECHANISMS UNDERLYING GROWTH HORMONE EFFECTS IN AUGMENTING NITRIC OXIDE PRODUCTION AND PROTEIN TYROSINE NITRATION DURING ENDOTOXIN CHALLENGE - (Peer Reviewed Journal)

Elsasser, T.H., Kahl, S., MacLeod, C., Nicholson, B., Sartin, J.L., Li, C. 2004. Mechanisms underlying growth hormone effects in augmenting nitric oxide production and protein tyrosine nitration during endotoxin challenge. Endocrinology. 145(7):3413-3423.

CHROMOSOME REPLICATION: EUKARYOTIC DNA REPLICATION ORIGINS AND THE ORIGIN RECOGNITION COMPLEX - (Review Article)

DePamphilis, M.L., Li, C. 2004. DNA replication: eukaryotic origins and the origin recognition complex. Encyclopedia of Biological Chemistry (W.J. Lennarz & M.D. Lane, eds), Elsevier, Oxford. vol. 1:753-760.

REGULATION OF "ORC CYCLE" BY UBIQUITINATION AND CDC2/CDK1 AT DIFFERENT EVENTS OF THE CELL CYCLE - (Abstract) - (03-Apr-03)

INDUCTION OF APOPTOSIS BY BUTYRATE CORRELATES WITH INCREASING LEVEL OF PROTEIN UBIQUITINATION IN BOVINE KIDNEY EPITHELIAL CELLS (MDBK) - (Abstract)

Li, C., Elsasser, T.H. 2003. Induction of apoptosis by butyrate correlates with increasing level of protein ubiquitination in bovine kidney epithelial cells (MDBK) [abstract]. Journal of Animal Science. v. 81(1):249.