Project Number: 6612-32000-048-04
Project Type: Trust

Start Date: Aug 22, 2006
End Date: Oct 31, 2008

Objective:
The purpose of these studies is to evaluate the serum and mucosal immune response of chicken to intranasal and intramuscular immunization with the AdVIET1203.H5 adneovirus-vectored influenza vaccine, and to determine the efficacy of this vaccine in preventing morbidity and mortality, and reduction of viral shed following a lethal avian influenza challenge.

Approach:
Two immunogenicity studies and two efficacy studies will be conducted using the adenovirus-vectored influenza vaccine in chickens. Different routes of inoculation and vaccine doses will be examined. In the efficacy studies chickens will be challenged with different influenza viruses. Determination of both humoral and mucosal immune response will be evaluated, as also protection against lethal influenza infection.