Projects

FOOT-AND-MOUTH DISEASE VIRUS (FMDV) COUNTERMEASURES DISCOVERY Appropriated (D)   Accession Number: 412008

FOOT-AND-MOUTH DISEASE VIRUS (FMDV) HOST-PATHOGEN INTERACTIONS Appropriated (D)   Accession Number: 411986

ADVANCED VACCINES FOR FOOT-AND-MOUTH DISEASE AND CLASSICAL SWINE FEVER Appropriated (D)   Accession Number: 412878

VESICULAR STOMATITIS VIRUS (VSV) HOST-PATHOGEN INTERACTIONS Appropriated (D)   Accession Number: 412016

DEVELOPMENT OF METHODOLOGY FOR APPLICATION TO FOREIGN ANIMAL DISEASE DIAGNOSTICS, SURVEILLANCE, DETECTION, CONTROL AND ERADICATION Nonfunded Cooperative Agreement (N)   Accession Number: 414174

EVALUATION OF INACTIVATED FMD VACCINES AND RECOMBINANT VIRAL-VECTORED FMD AND ANTIVIRAL VACCINE CANDIDATES Reimbursable (R)   Accession Number: 409583

RESEARCH AND DEVELOPMENT OF METHODOLOGY FOR TESTING CHEMICAL INACTIVATION OF HIGH CONSEQUENCE VIRAL DISEASE AGENTS Reimbursable (R)   Accession Number: 414776

BIOTHERAPEUTICS DEVELOPMENT AGAINST FOOT-AND-MOUTH DISEASE IN SWINE Reimbursable (R)   Accession Number: 412545

THE ROLE OF INSECT VECTOR TRANSMISSION IN THE PATHOGENESIS OF VESICULAR STOMATITIS VIRUS Specific Cooperative Agreement (S)   Accession Number: 410112

ADVANCED VETERINARY VACCINES AND DIAGNOSTICS Specific Cooperative Agreement (S)   Accession Number: 409541

HIGH CONSEQUENCE PATHOGEN DETECTION Specific Cooperative Agreement (S)   Accession Number: 406999

NOVEL RECOMBINANT ADENOVIRUS VACCINE AND ANTIVIRAL VECTORS TO CONTROL FMDV Specific Cooperative Agreement (S)   Accession Number: 408929

MOLECULAR PATHOGENESIS OF VESICULAR STOMATITIS VIRUS IN CATTLE Specific Cooperative Agreement (S)   Accession Number: 408415

CHARACTERIZATION OF LOCAL ISOLATES OF FOOT-AND-MOUTH DISEASE VIRUSES AND DEVELOPMENT OF VECTOR BASED VACCINES Specific Cooperative Agreement (S)   Accession Number: 412556

DEVELOPING PREDICTIVE TOOLS FOR PREVENTION OF FOOT-AND-MOUTH DISEASE Specific Cooperative Agreement (S)   Accession Number: 412327

ASSESSMENT OF THE ROLE OF FOOT-AND-MOUTH DISEASE VIRUS (FMDV) PROTEINS IN VIRAL PATHOGENESIS Specific Cooperative Agreement (S)   Accession Number: 411126

VESICULAR STOMATITIS MULTIPLE REAL-TIME PCR ASSAY DEVELOPMENT Specific Cooperative Agreement (S)   Accession Number: 407147

IMMUNE RESPONSE AND PATHOGENESIS IN SWINE TO FMDV, VSV AND PRRSV Specific Cooperative Agreement (S)   Accession Number: 405380

VESICULAR STOMATITIS OUTBREAK FIELD INVESTIGATIONS AND EPIDEMIOLOGICAL STUDIES OF ENDEMIC AREAS Specific Cooperative Agreement (S)   Accession Number: 410003

MEASURING IMMUNE RESPONSES TO VACCINATION WITH FOOT-AND-MOUTH DISEASE VIRUS (FMDV) IN CATTLE Specific Cooperative Agreement (S)   Accession Number: 408504

CLASSICAL SWINE FEVER VIRUS: ROLE OF THE 3'UTR IN INFECTIVITY OF SWINE Specific Cooperative Agreement (S)   Accession Number: 409306

MOLECULAR PATHOGENESIS AND IMMUNE RESPONSE OF FOOT-AND-MOUTH DISEASE VIRUS AND PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS Specific Cooperative Agreement (S)   Accession Number: 412181

PROGRAM FOR PREVENTION OF ANIMAL INFECTIOUS DISEASES AND ADVANCED TECHNOLOGIES FOR VACCINES AND DIAGNOSTICS Specific Cooperative Agreement (S)   Accession Number: 409533

RAPID DIAGNOSTIC TESTS FOR FOREIGN ANIMAL DISEASES Other (X)   Accession Number: 412060

Publications

Characterization of the Full-Length Genomic Sequence of Vesicular Stomatitis Cocal and Alagoas Viruses - (Peer Reviewed Journal)

Pauszek, S.J., Allende, R., Rodriguez, L.L. 2008. Characterization of the Full-Length Genomic Sequence of Vesicular Stomatitis Cocal and Alagoas Viruses. Archives of Virology. 153:1353-1357.

Role of the Region Located Between the Two AUG Initiation Codons in the Pathogenesis of Foot-and-Mouth Disease Virus (FMDV) - (Abstract)

Piccone, M.E., Pacheco Tobin, J., Pauszek, S.J., Borca, M.V., Rieder, A.E., Rodriguez, L.L. 2008. Role of the Region Located Between the Two AUG Initiation Codons in the Pathogenesis of Foot-and-Mouth Disease Virus (FMDV). European Study Group on the Molecular Biology of Picornaviruses. p. 199.

Preclinical Detection of Foot-and-Mouth Disease Virus Infected Cattle Using Infrared Thermography - (Peer Reviewed Journal) - (05-Jan-08)

Rapid Preclinical Detection of Sheeppox Virus by a Real-Time PCR Assay - (Peer Reviewed Journal)

Balinsky, C.A., Delhon, G., Smoliga, G.R., Prarat, M., French, R.A., Geary, S.J., Rock, D.L., Rodriguez, L.L. 2008. Rapid Preclinical Detection of Sheeppox Virus by a Real-Time PCR Assay. Journal of Clinical Microbiology. 46(2):438-442.

Global FMD control - Is it an option? - (Peer Reviewed Journal)

Kitching, P., Hammond, J., Jeggo, M., Charleston, B., Paton, D., Rodriguez, L.L., Heckert, R. 2007. Global FMD control - Is it an option?. 2007 Vaccine. July 26; 25(30): 5660-5664.

Molecular Epidemiology of Vesicular Stomatitis New Jersey Virus from the 2004-2005 United States Outbreak Indicates a Common Origin with Mexico Strains - (Peer Reviewed Journal)

Rainwater-Lovett, K., Pauszek, S.J., Kelley, W.N., Rodriguez, L.L. 2007. Molecular Epidemiology of Vesicular Stomatitis New Jersey Virus from the 2004-2005 United States Outbreak Indicates a Common Origin with Mexico Strains. Journal of General Virology. 88 (Pt7): 2042-51.

THERMAL INACTIVATION OF FOOT-AND-MOUTH DISEASE VIRUS IN MILK USING HIGH-TEMPERATURE SHORT TIME PASTEURIZATION - (Peer Reviewed Journal)

Tomasula, P.M., Kozempel, M.F., Konstance, R.P., Gregg, D.A., Boettcher, S., Baxt, B., Rodriguez, L.L. 2007. Thermal inactivation of foot-and-mouth disease virus in milk using high-temperature short time pasteurization. Journal of Dairy Sci. 90:3202-3211.

Mosaic Structure of Foot-and-Mouth Disease Virus Genomes - (Peer Reviewed Journal)

Jackson, A.L., Van Rensburg, H., Carrillo, C., Rodriguez, L.L., Haydon, D. 2007. Mosaic Structure of Foot-and-Mouth Disease Virus Genomes. Journal of General Virology. 88(Pt 2: 487-92.

EXPERIMENTAL VESICULAR STOMATITIS NEW JERSEY VIRUS (VSVNJV) INFECTION IN CATTLE: PATHOGENESIS, VIRUS DISTRIBUTION AND LOCALIZATION DETERMINED BY USING CONFOCAL MICROSCOPY - (Peer Reviewed Journal) - (26-Sep-06)

Quality Sample Collection, Handling, and Preservation for an Effective Microbial Forensics Program - (Review Article)

Budowle, B., Schutzer, S.E., Burans, J.P., Beecher, D.J., Cebula, T.A., Chakraborty, R., Cobb, W.T., Fletcher, J., Hale, M.L., Harris, R.B., Heitkamp, M.A., Keller, F.P., Kuske, C., Leclerc, J.E., Marrone, B.L., Mckenna, T.S., Morse, S.A., Rodriguez, L.L., Valentine, N.B., Yadev, J. 2006. Quality Sample Collection, Handling, and Preservation for an Effective Microbial Forensics Program. Applied and Environmental Microbiology. 72 (10): 6431-8.

GENETIC ANALYSIS OF VESICULAR STOMATITIS VIRUSES FROM THE 2004-2005 U.S. OUTBREAK - (Abstract)

Pauszek, S.J., Rainwater, K., Rodriguez, L.L. 2006. Genetic analysis of Genetic Analysis of Vesicular Stomatitis Viruses from the 2004-2005 U.S. outbreak. American Society for Virology Annual Meeting. P. 166, 35-4.

Diagnostic evaluation of a reverse transcribed real time PCR assay for vesicular stomatitis in horses - (Abstract)

Koster, L., Landgraf, J., Swenson, S., Rodamaker, M., Emery, M., Smoliga, G.R., Rodriguez, L.L. 2005. Diagnostic evaluation of a reverse transcribed real time PCR assay for vesicular stomatitis in horses. American Association of Veterinary Laboratory Diagnosticians 48th Annual Conference. P. 92.

VESICULAR DISEASES - (Book/Chapter)

Rodriguez, L.L., Lubroth, J., Dekker, A. 2005 Chapter 31 Vesicular Diseases. Barbara Straw, Editor, Diseases of Swine, Nineth Edition, Iowa State Press, Ames, Iowa, Blackwell Publishing, p.517-535.

A LANCET DESIGNED FOR THE SIMPLE AND HUMANE CHEEK POUCH BLEEDING OF MICE - (Peer Reviewed Journal)

Golde, W.T., Gollobin, P., Rodriguez, L.L. 2005. A Lancet Designed for the Simple and Humane Cheek Pouch Bleeding of Mice. Lab Animal. Vol. 34:9, P. 39-43.

VACCINATION AGAINST FOOT-AND-MOUTH DISEASE VIRUS CONFERS COMPLETE CLINICAL PROTECTION IN 7 DAYS AND PARTIAL PROTECTION IN 4 DAYS:USE IN EMERGENCY OUTBREAK RESPONSE - (Peer Reviewed Journal)

Golde, W.T., Pacheco-Tobin, J., Duque, H., Doel, T., Penfold, B., Ferman Ii, G.S., Gregg, D.A., Rodriguez, L.L. 2005. Vaccination against foot-and-mouth disease virus confers complete clinical protection in 7 days and partial protection in 4 days:use in emergency outbreak response. Vaccine 23 (2005) 5775-5782.

NOVEL TOOLS TO PREVENT AND ERADICATE FOREIGN ANIMAL DISEASES - (Abstract)

Rodriguez, L.L., Baxt, B., Rieder, A.E., Golde, W.T., Borca, M.V., Grubman, M.J. 2005. Novel tools to prevent and eradicate foreign animal diseases. American Society for Microbiology Biodefense Meeting. p 41.

EARLY DEVELOPMENT OF ADENOVIRUS-VECTORED FMD VACCINE AND ANTIVIRAL - (Abstract)

Grubman, M.J., Golde, W.T., Rodriguez, L.L. 2004. Early development of adenovirus-vectored fmd vaccine and antiviral. Meeting Abstract.

Validation of a real-time RT-PCR for vesicular stomatitis virus - (Abstract)

Letchworth, G., Jimenez, C., Herrero, M., Cornish, T., Wilson, W.C., Smoliga, G.R., Pauszek, S.J., Dornak, C., George, M., Rodriguez, L.L. 2004. Validation of a real-time RT-PCR for vesicular stomatitis virus. Proc. Am. Assoc. of Vet. Lab. Diagn. 47:121. 2004.

VALIDATION OF A REAL-TIME RT-PCR FOR VESICULAR STOMATITIS VIRUS - (Proceedings/Symposium)

Rodriguez, L.L., Jimenez, C., Herrero, M., Cornish, T.E., Wilson, W.C., Letchworth, G.J., Pauszek, S.J., George, M., Smoliga, G.R. 2004. Validation of a real-time rt-pcr for vesicular stomatitis virus. American Association of Veterinary Laboratory Diagnosticians. P. 40

VESICULAR STOMATITIS NEW JERSEY VIRUS IN CATTLE: PATHOGENESIS, VIRUS DISTRIBUTION AND LOCAL IMMUNE RESPONSE - (Abstract)

Scherer, C.F., Golde, W.T., Gregg, D.A., Estes, D.M., Drolet, B.S., Rodriguez, L.L. 2004. Vesicular Stomatitis New Jersey Virus in Cattle: Pathogenesis, Virus Distribution and Local Immune Response. Conference of Research Workers in Animal Disease Annual Meeting. P. 198.

EARLY DEVELOPMENT OF ADENOVIRUS-VECTORED FMD VACCINE AND ANTIVIRAL - (Abstract)

Grubman, M.J., Golde, W.T., Rodriguez, L.L. 2004. Early Development of Adenovirus-vectored FMD Vaccine and Antiviral. European Commission for the Control of Foot-and-Mouth Disease, Chania, Crete, Greece. P. 45.

EFFECT OF PASTEURIZATION ON ELIMINATION OF FOOT-AND-MOUTH DISEASE VIRUS (FMDV) IN NATURALLY INFECTED COW'S MILK - (Abstract)

Tomasula, P.M., Gregg, D.A., Baxt, B., Rodriguez, L.L., Kozempel, M.F., Konstance, R.P. 2004. Effect of pasteurization on elimination of foot-and-mouth disease virus (FMDV) in naturally infected cow's milk. (abstract).International Food Technologists Meeting. Paper No. 46-3.

RECOMBINANT VESICULAR STOMATITIS (INDIANA) VIRUS EXPRESSING NEW JERSEY AND INDIANA GLYCOPROTEINS INCLUDES NEUTRALIZING ANTIBODIES TO EACH SEROTYPE IN SWINE, A NATURAL HOST - (Peer Reviewed Journal)

Martinez, I., Barrera, J., Rodriguez, L.L., Wertz, G.W. 2004. Recombinant vesicular stomatitis (indiana) virus expressing new jersey and indiana glycoproteins includes neutralizing antibodies to each serotype in swine, a natural host. Vaccine 22: 4035-4043.

A SINGLE-TUBE MULTIPLEX RT-PCR FOR DETECTION AND DIFFERENTIATION OF VESICULAR STOMATITIS INDIANA 1 AND NEW JERSEY VIRUSES IN INSECTS - (Peer Reviewed Journal)

MAGNUSON, R.J., TRIANTIS, J., RODRIGUEZ, L.L., PERKINS, A., MEREDITH, C.O., BEATY, B., MCCLUSKEY, B., SALMAN, M. 2003. A SINGLE-TUBE MULTIPLEX RT-PCR FOR DETECTION AND DIFFERENTIATION OF VESICULAR STOMATITIS INDIANA 1 AND NEW JERSEY VIRUSES IN INSECTS. JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION. 15(6):561-567.

A SYNTHETIC PEPTIDE CONTAINING THE CONSENSUS SEQUENCE OF THE G-H LOOP REGION OF FMDV TYPE O VP1 COMBINED WITH A PROMISCUOUS T-HELPER EPITOPE INDUCES PEPTIDE-SPECIFIC AB BUT FAILS TO PROTECT CATTLE AGAINST VIRAL CHALLENGE - (Peer Reviewed Journal)

RODRIGUEZ, L.L., BARRERA, J.D., KRAMER, E., LUBROTH, J., BROWN, F., GOLDE, W.T. A SYNTHETIC PEPTIDE CONTAINING THE CONSENSUS SEQUENCE OF THE G-H LOOP REGION OF FMDV TYPE O VP1 COMBINED WITH A PROMISCUOUS T-HELPER EPITOPE INDUCES PEPTIDE-SPECIFIC AB BUT FAILS TO PROTECT CATTLE AGAINST VIRAL CHALLENGE. VACCINE, VOLUME 21: 3751-3756, 2003.

VESICULAR STOMATITIS VIRUS GLYCOPROTEIN IS A DETERMINANT OF PATHOGENESIS IN SWINE, A NATURAL HOST - (Peer Reviewed Journal)

MARTINEZ, I., RODRIGUEZ, L.L., JIMENEZ, C.F., PAUSZEK, S.J., WERTZ, G.W. VESICULAR STOMATITIS VIRUS GLYCOPROTEIN IS A DETERMINANT OF PATHOGENESIS IN SWINE, A NATURAL HOST. JOURNAL OF VIROLOGY. 77L8039-8047, 2003.