Projects

FOOT-AND-MOUTH DISEASE VIRUS (FMDV) COUNTERMEASURES DISCOVERY Appropriated (D)   Accession Number: 412008

FOOT-AND-MOUTH DISEASE VIRUS (FMDV) HOST-PATHOGEN INTERACTIONS Appropriated (D)   Accession Number: 411986

Publications

Role of IL-10 during Foot-and-Mouth Disease Virus (FMDV) Infection and Its Potential Use as Immunomodulator - (Abstract) - (01-Oct-08)

Type I and II Interferons Activate the Innate Immune System to Promote Early Protection of Swine Against Foot-and-Mouth Disease Virus - (Abstract)

Diaz-San Segundo, F., Moraes, M., De Los Santos, T., Pacheco Tobin, J., Koster, M.J., Dawson, H., Golde, W.T., Grubman, M.J. 2008. Type I and II Interferons Activate the Innate Immune System to Promote Early Protection of Swine Against Foot-and-Mouth Disease Virus. European Study Group on the Molecular Biology of Picornaviruses. P 149

A Conserved Domain in the Leader Proteinase of Foot-and-Mouth Disease Virus is Required for Proper Subcellular Localization and Function - (Abstract)

De Los Santos, T., San Segundo-Diaz, F., Zhu, J., Koster, M.J., Grubman, M.J. 2008. A conserved domain in the leader proteinase of foot-and-mouth disease virus is required for proper subcellular localization and function. European Study Group on the Molecular Biology of Picornaviruses. P 86

Evading the Host Immune Response: How Foot-and-Mouth Disease Virus Has Become an Effective Pathogen - (Peer Reviewed Journal)

Grubman, M.J., Moraes, M., Diaz-San Segundo, F., Pena, L., De Los Santos, T. 2008. Evading the Host Immune Response: How Foot-and-Mouth Disease Virus Has Become an Effective Pathogen. Federation of European Microbiological Societies Microbiology Letters. 53:8-17.

Degradation of Nuclear Factor Kappa B During Foot-and-Mouth Disease Virus Infection - (Peer Reviewed Journal)

De Los Santos, T., Diaz-San Segundo, F., Grubman, M.J. 2007. Degradation of Nuclear Factor Kappa B During Foot-and-Mouth Disease Virus Infection. Journal of Virology. 81(23):12803-12815.

Enhanced Antiviral Activity against Foot-and-Mouth Disease Virus by a Combination of Type 1 and 2 Porcine Interfereons - (Peer Reviewed Journal)

Moraes, M., De Los Santos, T., Koster, M.J., Turecek, T.E., Wang, H., Andreyev, V.G., Grubman, M.J. 2007. Enhanced Antiviral Activity against Foot-and-Mouth Disease Virus by a Combination of Type 1 and 2 Porcine Interfereons. Journal of Virology. Vol 81. No.13: P7124-7135

Degradation of Nuclear Factor Kappa B During Foot-and-Mouth Disease Virus Infection - (Abstract)

De Los Santos, T., Diaz San-Segundo, F., Grubman, M.J., 2007, Degradation of Nuclear Factor Kappa B During Foot-and-Mouth Disease Virus Infection. American Society for Virology Meeting. W1-3, p.71

Porcine Interferon Gamma Promotes a Protective Innate Immune Response Against Foot-and-Mouth Disease in Swine - (Abstract)

Diaz-San Segundo, F., Moraes, M., De Los Santos, T., Pacheco Tobin, J., Koster, M.J., Turecek, T.E., Dawson, H., Golde, W.T., Grubman, M.J. 2007 Porcine Interferon Gamma Promotes a Protective Innate Immune Response Against Foot-and-Mouth Disease in Swine. American Society for Virology Meeting. W20-3, P. 30

THE LEADER PROTEINASE OF FOOT-AND-MOUTH DISEASE VIRUS REDUCES THE EXPRESSION OF INTERFERON BY SUPPRESSING THE ACTIVITY OF THE NUCLEAR FACTOR KAPPA B - (Abstract)

De Los Santos, T., Brum, M., Grubman, M.J. 2006. The leader proteinase of foot-and-mouth disease virus reduces the expression of interferon by suppressing the activity of the nuclear factor kappa b. American Society of Virology Annual Meeting. 2006. P. 67.

ENHANCED ANTIVIRAL ACTIVITY AGAINST FOOT-AND-MOUTH DISEASE VIRUS BY A COMBINATION OF TYPE 1 AND 2 PORCINE INTERFERONS - (Abstract)

Grubman, M.J., De Los Santos, T., Koster, M.J., Turecek, T.E., Wang, H., Andryev, V., Moraes, M.P. 2006. Enhanced antiviral activity against foot-and-mouth disease virus by a combination of type 1 and 2 porcine interferons. American Society of Virology Annual Meeting. 2006. P. 150.

THE LEADER PROTEINASE OF FOOT-AND-MOUTH DISEASE VIRUS INHIBITS THE INDUCTION OF INTERFERON BETA MRNA AND BLOCKS THE HOST INNATE IMMUNE RESPONSE - (Peer Reviewed Journal)

De Los Santos, T., Botton, S.D., Weiblen, R., Grubman, M.J. 2005. The Leader Proteinase of Foot-and-Mouth Disease Virus Inhibits the Induction of Interferon Beta mRNA and Blocks the Host Innate Immune Response. Journal of Virology.(2006) 80.4.1906-1914

THE LEADER PROTEINASE OF FOOT-AND-MOUTH DISEASE VIRUS INHIBITS THE INDUCTION OF INTERFERON BETA MRNA AND BLOCKS THE HOST INNATE IMMUNE RESPONSE - (Abstract)

De Los Santos, T., Botton, S.D., Grubman, M.J. 2005. The Leader Proteinase of Foot-and-Mouth Disease Virus Inhibits the Induction of Interferon Beta mRNA and Blocks the Host Innate Immune Response. American Society for Virology 24th Annual Meeting. P. W3-2.

THE LEADER PROTEINASE OF FOOT-AND-MOUTH DISEASE VIRUS INHIBITS THE INDUCTION OF INTERFERON BETA MRNA AND BLOCKS THE HOST INNATE IMMUNE RESPONSE - (Abstract)

De Los Santos, T., De Avila Botton, S., Grubman, M.J. 2005. The Leader Proteinase of Foot-and-Mouth Disease Virus Inhibits the Induction of Interferon Beta mRNA and Blocks the Host Innate Immune Response. European Study Grop on the Molecular Biology of Picornaviruses (ERUOPIC)2005. P. G06.

SHORT HAIRPIN RNA TARGETED TO THE HIGHLY CONSERVED 2B NONSTRUCTURAL PROTEIN CODING REGION INHIBITS REPLICATION OF MULTIPLE SEROTYPES OF FOOT-AND-MOUTH DISEASE VIRUS - (Peer Reviewed Journal)

De Los Santos, T., Wu, Q., Botton, S., Grubman, M.J. 2005. Short Hairpin RNA Targeted to the Highly Conserved 2B Nonstructural Protein Coding Region Inhibits Replication of Multiple Serotypes of Foot-and-Mouth Disease Virus. Virology. 335: P222-231.

RAPID CONTROL OF FOOT-AND-MOUTH DISEASE: IS RNAI A POSSIBLE SOLUTION? - (Review Article)

De Los Santos, T., Grubman, M.J. 2005. Rapid Control of Foot-and-Mouth Disease: Is RNAi a Possible Solution?. Trends in Immunology 26 (2)P 65-68.