Projects

FOOT-AND-MOUTH DISEASE VIRUS (FMDV) COUNTERMEASURES DISCOVERY Appropriated (D)   Accession Number: 412008

FOOT-AND-MOUTH DISEASE VIRUS (FMDV) HOST-PATHOGEN INTERACTIONS Appropriated (D)   Accession Number: 411986

BIOTHERAPEUTICS DEVELOPMENT AGAINST FOOT-AND-MOUTH DISEASE IN SWINE Reimbursable (R)   Accession Number: 412545

NOVEL RECOMBINANT ADENOVIRUS VACCINE AND ANTIVIRAL VECTORS TO CONTROL FMDV Specific Cooperative Agreement (S)   Accession Number: 408929

MOLECULAR PATHOGENESIS AND IMMUNE RESPONSE OF FOOT-AND-MOUTH DISEASE VIRUS AND PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS Specific Cooperative Agreement (S)   Accession Number: 412181

MEASURING IMMUNE RESPONSES TO VACCINATION WITH FOOT-AND-MOUTH DISEASE VIRUS (FMDV) IN CATTLE Specific Cooperative Agreement (S)   Accession Number: 408504

Publications

Adenovirus-Mediated Expression of Interferon-Alpha Delays Viral Replication and Reduces Disease Signs in Swine Challenged with Porcine Reproductive and Respiratory Syndrome Virus - (Peer Reviewed Journal) - (24-Jan-09)

Role of IL-10 during Foot-and-Mouth Disease Virus (FMDV) Infection and Its Potential Use as Immunomodulator - (Abstract) - (01-Oct-08)

Delivery of a Foot-and-Mouth Disease Virus Empty Capsid Subunit Antigen with Nonstructural Protein 2B Improves Protection of Swine - (Trade Journal)

Pena, L., Moraes, M., Koster, M.J., Burrage, T., Pacheco Tobin, J., Diaz San-Segundo, F., Grubman, M.J. 2008. Delivery of a Foot-and-Mouth Disease Virus Empty Capsid Subunit Antigen with Nonstructural Protein 2B Improves Protection of Swine. Vaccine 26: 5689-5699.

Cellular Changes Induced by Adenovirus Vaccine Vectors Expressing Foot-and-Mouth Disease Virus Structural and Nonstructural Proteins - (Abstract)

Moraes, M., O'Donnell, V.K., Burrage, T.G., Pena, L., Diaz-San Segundo, F., Koster, M.J., Zhu, J., Grubman, M.J. 2008. Cellular Changes Induced by Adenovirus Vaccine Vectors Expressing Foot-and-Mouth Disease Virus Structural and Nonstructural Proteins. European Study Group on the Molecular Biology of Picornaviruses. P 203

Type I and II Interferons Activate the Innate Immune System to Promote Early Protection of Swine Against Foot-and-Mouth Disease Virus - (Abstract)

Diaz-San Segundo, F., Moraes, M., De Los Santos, T., Pacheco Tobin, J., Koster, M.J., Dawson, H., Golde, W.T., Grubman, M.J. 2008. Type I and II Interferons Activate the Innate Immune System to Promote Early Protection of Swine Against Foot-and-Mouth Disease Virus. European Study Group on the Molecular Biology of Picornaviruses. P 149

A Conserved Domain in the Leader Proteinase of Foot-and-Mouth Disease Virus is Required for Proper Subcellular Localization and Function - (Abstract)

De Los Santos, T., San Segundo-Diaz, F., Zhu, J., Koster, M.J., Grubman, M.J. 2008. A conserved domain in the leader proteinase of foot-and-mouth disease virus is required for proper subcellular localization and function. European Study Group on the Molecular Biology of Picornaviruses. P 86

Evading the Host Immune Response: How Foot-and-Mouth Disease Virus Has Become an Effective Pathogen - (Peer Reviewed Journal)

Grubman, M.J., Moraes, M., Diaz-San Segundo, F., Pena, L., De Los Santos, T. 2008. Evading the Host Immune Response: How Foot-and-Mouth Disease Virus Has Become an Effective Pathogen. Federation of European Microbiological Societies Microbiology Letters. 53:8-17.

Degradation of Nuclear Factor Kappa B During Foot-and-Mouth Disease Virus Infection - (Peer Reviewed Journal)

De Los Santos, T., Diaz-San Segundo, F., Grubman, M.J. 2007. Degradation of Nuclear Factor Kappa B During Foot-and-Mouth Disease Virus Infection. Journal of Virology. 81(23):12803-12815.

Enhanced Antiviral Activity against Foot-and-Mouth Disease Virus by a Combination of Type 1 and 2 Porcine Interfereons - (Peer Reviewed Journal)

Moraes, M., De Los Santos, T., Koster, M.J., Turecek, T.E., Wang, H., Andreyev, V.G., Grubman, M.J. 2007. Enhanced Antiviral Activity against Foot-and-Mouth Disease Virus by a Combination of Type 1 and 2 Porcine Interfereons. Journal of Virology. Vol 81. No.13: P7124-7135

Degradation of Nuclear Factor Kappa B During Foot-and-Mouth Disease Virus Infection - (Abstract)

De Los Santos, T., Diaz San-Segundo, F., Grubman, M.J., 2007, Degradation of Nuclear Factor Kappa B During Foot-and-Mouth Disease Virus Infection. American Society for Virology Meeting. W1-3, p.71

Enhanced Antiviral Activity Against Foot-and-Mouth Disease Virus by the Combination of Bovine Type 1 and 2 Interferons - (Abstract)

Moraes, M., Koster, M.J., Grubman, M.J., 2007, Enhanced Antiviral Activity Against Foot-and-Mouth Disease Virus by the Combination of Bovine Type 1 and 2 Interferons. American Society for Virology Meeting. P8-8, P.54

Delivery of Both Foot-and-Mouth Disease Virus Structural and Nonstructural Antigens Improves Protection of Swine - (Abstract)

Pena, L., Koster, M.J., Diaz San-Segundo, F., Grubman, M.J., 2007, Delivery of Both Foot-and-Mouth Disease Virus Structural and Nonstructural Antigens Improves Protection of Swine. American Society for Virology Meeting. W52-10, p.50.

Porcine Interferon Gamma Promotes a Protective Innate Immune Response Against Foot-and-Mouth Disease in Swine - (Abstract)

Diaz-San Segundo, F., Moraes, M., De Los Santos, T., Pacheco Tobin, J., Koster, M.J., Turecek, T.E., Dawson, H., Golde, W.T., Grubman, M.J. 2007 Porcine Interferon Gamma Promotes a Protective Innate Immune Response Against Foot-and-Mouth Disease in Swine. American Society for Virology Meeting. W20-3, P. 30

Protection Of Alveolar Macrophages And MARC 145 Cells From Porcine Reproductive And Respiratory Syndrome Virus Challenge By Swine Interferon-Beta - (Abstract)

Overend, C., Mitchell, R., He, D., Rompato, G., Grubman, M.J., Garmendia, A.E. 2006. Protection Of Alveolar Macrophages And MARC 145 Cells From Porcine Reproductive And Respiratory Syndrome Virus Challenge By Swine Interferon-Beta International Porcine Reproductive and Respiratiory Syndrome (PRRS) Symposium 2006. P. 26. . Porcine Reproductive and Respiratory Syndrome International Symposium.

Enhanced antiviral activity against foot-and-mouth disease virus by the combination of bovine type 1 and 2 interferons - (Abstract)

Moraes, M., Koster, M.J., Grubman, M.J. 2006. Enhanced antiviral activity against foot-and-mouth disease virus by the combination of bovine type 1 and 2 interferons. Sociedade Brasileira de Virology. 74-op. P.74.

RECOMBINANT SWINE INTERFERON BETA PROTECTS SWINE ALVEOLAR MACROPHAGES AND MARC 145 CELLS FROM INFECTION WITH PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS - (Peer Reviewed Journal)

Overend, C., Mitchell, R., He, D., Rompato, G., Grubman, M.J., Garmendia, A.E. 2007. Recombinant swine interferon beta protects swine alveolar macrophages and marc 145 cells from infection with porcine reproductive and respiratory syndrome virus. Journal of General Virology. 88(Pt 3): 925-31.

Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus - (Abstract)

Brockmeier, S.L., Lager, K.M., Grubman, M.J., Brough, D., Ettyreddy, D., Sacco, R.E., Gauger, P.C., Lehmkuhl, H.D. 2006. Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus. Proceedings of the 87th Conference of Research Workers in Animal Diseases, December 3-5, 2006. Chicago, Illinois. p.124.

Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus - (Abstract)

Brockmeier, S.L., Lager, K.M., Grubman, M.J., Brough, D., Ettyreddy, D., Sacco, R.E., Gauger, P.C., Lehmkuhl, H.D. 2006. Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus. Proceeding of the International PRRS Symposium, December 1-2, 2006, Chicago, Illinois. p. 27.

ENHANCED ANTIVIRAL ACTIVITY AGAINST FOOT-AND-MOUTH DISEASE VIRUS BY A COMBINATION OF TYPE 1 AND 2 PORCINE INTERFERONS - (Abstract)

Grubman, M.J., De Los Santos, T., Koster, M.J., Turecek, T.E., Wang, H., Andryev, V., Moraes, M.P. 2006. Enhanced antiviral activity against foot-and-mouth disease virus by a combination of type 1 and 2 porcine interferons. American Society of Virology Annual Meeting. 2006. P. 150.

THE LEADER PROTEINASE OF FOOT-AND-MOUTH DISEASE VIRUS REDUCES THE EXPRESSION OF INTERFERON BY SUPPRESSING THE ACTIVITY OF THE NUCLEAR FACTOR KAPPA B - (Abstract)

De Los Santos, T., Brum, M., Grubman, M.J. 2006. The leader proteinase of foot-and-mouth disease virus reduces the expression of interferon by suppressing the activity of the nuclear factor kappa b. American Society of Virology Annual Meeting. 2006. P. 67.

IMMUNOPOTENTIATION OF A FOOT-AND-MOUTH DISEASE VIRUS SUBUNIT VACCINE BY INTERFERON ALPHA - (Peer Reviewed Journal)

Botton, S.D., Brum, M.C., Bautista-Peck, E.M., Koster, M.J., Weiblen, R., Golde, W.T., Grubman, M.J. 2006. Immunopotentiation of a foot-and-mouth disease virus subunit vaccine by interferon alpha. Vaccine. (2006) 24: 3446-3456.

NEW APPROACHES TO CONTROL FOOT-AND-MOUTH DISEASE: ANTIVIRALS AND NOVEL VACCINES - (Peer Reviewed Journal)

Grubman, M.J. 2006. New approaches to control foot-and-mouth disease: antivirals and novel vaccines. Colombiana de Ciencias Pecuarias. 19: 341-346.

THE LEADER PROTEINASE OF FOOT-AND-MOUTH DISEASE VIRUS INHIBITS THE INDUCTION OF INTERFERON BETA MRNA AND BLOCKS THE HOST INNATE IMMUNE RESPONSE - (Peer Reviewed Journal)

De Los Santos, T., Botton, S.D., Weiblen, R., Grubman, M.J. 2005. The Leader Proteinase of Foot-and-Mouth Disease Virus Inhibits the Induction of Interferon Beta mRNA and Blocks the Host Innate Immune Response. Journal of Virology.(2006) 80.4.1906-1914

DEVELOPMENT OF NOVEL STRATEGIES TO CONTROL FOOT-AND-MOUTH DISEASE: MARKER VACCINES AND ANTIVIRALS - (Peer Reviewed Journal)

Grubman, M.J. 2005. Development of Novel Strategies to Control Foot-and-Mouth Disease: Marker Vaccines and Antivirals. Biologicals 33 (2005) 227-234.

RAPID PROTECTION OF CATTLE FROM DIRECT CHALLENGE WITH FOOT-AND-MOUTH DISEASE VIRUS (FMDV) BY A SINGLE INOCULAITON WITH AN ADENOVIRUS VECTORED FMDV SUBUNIT VACCINE - (Peer Reviewed Journal)

Pacheco, J., Brum, M., Moraes, M., Golde, W.T., Grubman, M.J. 2005. Rapid Protection of Cattle from Direct Challenge with Foot-and-Mouth Disease Virus (FMDV) by a Single Inoculaiton with an Adenovirus Vectored FMDV Subunit Vaccine. Virology. 337: P205-209.

THE LEADER PROTEINASE OF FOOT-AND-MOUTH DISEASE VIRUS INHIBITS THE INDUCTION OF INTERFERON BETA MRNA AND BLOCKS THE HOST INNATE IMMUNE RESPONSE - (Abstract)

De Los Santos, T., De Avila Botton, S., Grubman, M.J. 2005. The Leader Proteinase of Foot-and-Mouth Disease Virus Inhibits the Induction of Interferon Beta mRNA and Blocks the Host Innate Immune Response. European Study Grop on the Molecular Biology of Picornaviruses (ERUOPIC)2005. P. G06.

THE LEADER PROTEINASE OF FOOT-AND-MOUTH DISEASE VIRUS INHIBITS THE INDUCTION OF INTERFERON BETA MRNA AND BLOCKS THE HOST INNATE IMMUNE RESPONSE - (Abstract)

De Los Santos, T., Botton, S.D., Grubman, M.J. 2005. The Leader Proteinase of Foot-and-Mouth Disease Virus Inhibits the Induction of Interferon Beta mRNA and Blocks the Host Innate Immune Response. American Society for Virology 24th Annual Meeting. P. W3-2.

RAPID PROTECTION OF CATTLE FROM DIRECT CHALLENGE WITH FOOT-AND-MOUTH DISEASE VIRUS (FMDV) BY INOCULATION WITH AN ADENOVIRUS VECTORED FMDV SUBUNIT VACCINE - (Abstract)

Moraes, M., Pacheco, J., Brum, M., Golde, W.T., Grubman, M.J. 2005. Rapid Protection of Cattle from Direct Challenge with Foot-and-Mouth Disease Virus (FMDV) by Inoculation with an Adenovirus Vectored FMDV Subunit Vaccine. American Society for Virology 24th Annual Meeting. P. P9-5.

RAPID PROTECTION OF CATTLE FROM DIRECT CHALLENGE WITH FOOT-AND-MOUTH DISEASE VIRUS (FMDV) BY INOCULATION WITH AN ADENOVIRUS VECTORED FMDV SUBUNIT VACCINE - (Abstract)

Pacheco, J.M., Brum, M.C., Moraes, M.P., Golde, W.T., Grubman, M.J. 2005. Rapid Protection of Cattle from Direct Challenge with Foot-and-Mouth Disease Virus (FMDV) by Inoculation with an Adenovirus Vectored FMDV Subunit Vaccine. European Study Group on the Molecular Biology of Picornaviruses (ERUOPIC) 2005. P. I22.

ULTRASTRUCTURAL AND CONFOCAL MICROSCOPY ANALYSIS OF FOOT-AND-MOUTH VIRUS (FMDV) STRUCTURAL AND NO-STRUCTURAL PROTEINS ON REPLICATION COMPLEXES IN CULTURED CELLS - (Abstract)

Odonnell, V.K., Koster, M.J., Grubman, M.J., Baxt, B., Burrage, T.G. 2005. Ultrastructural and Confocal Microscopy Analysis of Foot-and-Mouth Virus (fmdv) Structural and No-structural Proteins on Replication Complexes in Cultured Cells. Microscopy and Microanalysis 2005. p 120.

SHORT HAIRPIN RNA TARGETED TO THE HIGHLY CONSERVED 2B NONSTRUCTURAL PROTEIN CODING REGION INHIBITS REPLICATION OF MULTIPLE SEROTYPES OF FOOT-AND-MOUTH DISEASE VIRUS - (Peer Reviewed Journal)

De Los Santos, T., Wu, Q., Botton, S., Grubman, M.J. 2005. Short Hairpin RNA Targeted to the Highly Conserved 2B Nonstructural Protein Coding Region Inhibits Replication of Multiple Serotypes of Foot-and-Mouth Disease Virus. Virology. 335: P222-231.

NOVEL TOOLS TO PREVENT AND ERADICATE FOREIGN ANIMAL DISEASES - (Abstract)

Rodriguez, L.L., Baxt, B., Rieder, A.E., Golde, W.T., Borca, M.V., Grubman, M.J. 2005. Novel tools to prevent and eradicate foreign animal diseases. American Society for Microbiology Biodefense Meeting. p 41.

RAPID CONTROL OF FOOT-AND-MOUTH DISEASE: IS RNAI A POSSIBLE SOLUTION? - (Review Article)

De Los Santos, T., Grubman, M.J. 2005. Rapid Control of Foot-and-Mouth Disease: Is RNAi a Possible Solution?. Trends in Immunology 26 (2)P 65-68.

CONSTITUTIVE EXPRESSION OF IFN-ALPHA BY PORCINE SKIN DENDRITIC CELLS CONFERS RESISTANCE TO INFECTION BY FOOT-AND-MOUTH DISEASE VIRUS (FMDV) - (Peer Reviewed Journal)

Bautista Peck, E.M., Ferman Ii, G.S., Gregg, D.A., Brum, M.C., Grubman, M.J., Golde, W.T. 2005. Constitutive Expression of IFN-alpha by Porcine Skin Dendritic Cells Confers Resistance to Infection by Foot-and-Mouth Disease Virus (FMDV). Journal of Virology 79 (8). P 4838-4847.

THE EFFECT OF GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR ON THE EFFICACY OF A FOOT-AND-MOUTH DISEASE VIRUS SUBUNIT VACCINE - (Peer Reviewed Journal) - (04-Nov-04)

EARLY DEVELOPMENT OF ADENOVIRUS-VECTORED FMD VACCINE AND ANTIVIRAL - (Abstract)

Grubman, M.J., Golde, W.T., Rodriguez, L.L. 2004. Early development of adenovirus-vectored fmd vaccine and antiviral. Meeting Abstract.

EARLY DEVELOPMENT OF ADENOVIRUS-VECTORED FMD VACCINE AND ANTIVIRAL - (Abstract)

Grubman, M.J., Golde, W.T., Rodriguez, L.L. 2004. Early Development of Adenovirus-vectored FMD Vaccine and Antiviral. European Commission for the Control of Foot-and-Mouth Disease, Chania, Crete, Greece. P. 45.

FOOT AND MOUTH DISEASE - (Book/Chapter)

GRUBMAN, M.J., BAXT, B. FOOT AND MOUTH DISEASE. Clinical Microbiological Reviews. 2004.V17, No 2: 465-493.

A NOVEL STRATEGY TO CONTROL INFECTIOUS VIRAL DISEASES: ADENOVIRUS CONTAINING INTERFERON ALPHA PROTECTS SWINE FROM FOOT-AND-MOUTH DISEASE - (Peer Reviewed Journal)

CHINSANGARAM, J., MORAES, M.P., KOSTER, M.J., GRUBMAN, M.J. A NOVEL STRATEGY TO CONTROL INFECTIOUS VIRAL DISEASES: ADENOVIRUS CONTAINING INTERFERON ALPHA PROTECTS SWINE FROM FOOT-AND-MOUTH DISEASE. JOURNAL OF VIROLOGY. V77(2):1621-1625, 2003

FOOT-AND-MOUTH DISEASE VIRUS L PEPTIDASE - (Other)

GRUBMAN, M.J. FOOT-AND-MOUTH DISEASE VIRUS L PEPTIDASE. HANDBOOK OF PROTEOLYTIC ENZYMES. C372:675-677, 2003.

NEW APPROACHES TO RAPIDLY CONTROL FOOT-AND-MOUTH DISEASE OUTBREAKS - (Review Article)

GRUBMAN, M.J. NEW APPROACHES TO RAPIDLY CONTROL FOOT-AND-MOUTH DISEASE OUTBREAKS. EXPERT REVIEW OF ANTI-INFECTIVE THERAPY.1(14):579-586, 2003

IMMEDIATE PROTECTION OF SWINE FROM FOOT-AND-MOUTH DISEASE: A COMBINATION OF ADENOVIRUSES EXPRESSING INTERFERON ALPHA AND A FOOT-AND-MOUTH DISEASE VIRUS SUBUNIT VACCINE - (Peer Reviewed Journal)

MORAES, M.P., CHINSANGARAM, J., BRUM, M.C., GRUBMAN, M.J. IMMEDIATE PROTECTION OF SWINE FROM FOOT-AND-MOUTH DISEASE: A COMBINATION OF ADENOVIRUSES EXPRESSING INTERFERON ALPHA AND A FOOT-AND-MOUTH DISEASE VIRUS SUBUNIT VACCINE. VACCINE. v22(2): 268-279, 2003.

ADENOVIRUS-MEDIATED TYPE I INTERFERON EXPRESSION PARTIALLY PROTECTS CATTLE FROM FOOT-AND-MOUTH DISEASE - (Peer Reviewed Journal)

WU, Q., BRUM, M.C., CARON, L., KOSTER, M.J., GRUBMAN, M.J. ADENOVIRUS-MEDIATED TYPE I INTERFERON EXPRESSION PARTIALLY PROTECTS CATTLE FROM FOOT-AND-MOUTH DISEASE. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. v23: 359-368, 2003.

NEW APPROACHES TO CONTROL FOOT-AND-MOUTH DISEASE - (Proceedings/Symposium) - (17-Mar-03)

RECOMBINAT ADENOVIRUS CO-EXPRESSING CAPSID PROTEINS OF TWO SEROTYPES OF FOOT-AND-MOUTH DISESE VIRUS(FMDV): IN VITRO CHARACTERIZATION AND INDUCTION OF NEUTRALIZING ANTIBODIES AGAINST FMDV IN SWINE - (Peer Reviewed Journal)

WU, Q., MORAES, M.P., GRUBMAN, M.J. RECOMBINAT ADENOVIRUS CO-EXPRESSING CAPSID PROTEINS OF TWO SEROTYPES OF FOOT-AND-MOUTH DISESE VIRUS(FMDV): IN VITRO CHARACTERIZATION AND INDUCTION OF NEUTRALIZING ANTIBODIES AGAINST FMDV IN SWINE. VIRUS RESEARCH. V93(2):211-219, 2003.

ENGINEERING BETTER VACCINES FOR FOOT-AND-MOUTH DISEASE - (Other)

MASON, P.W., CHINSANGARAM, J., MORAES, M.P., MAYR, G.A., GRUBMAN, M.J. ENGINEERING BETTER VACCINES FOR FOOT-AND-MOUTH DISEASE. DEVELOPMENTS IN BIOLOGICALS. V114: 79-88, 2003.

NEW APPROACHES TO CONTROL FOOT-AND-MOUTH DISEASE - (Other)

GRUBMAN, M.J., MORAES, M.P., CHINSANGARAM, J., MAYR, G.A., MASON, P.W. NEW APPROACHES TO CONTROL FOOT-AND-MOUTH DISEASE. FOOT-AND-MOUTH DISEASES: CONTROL STRATEGIES. p337-343, 2003