Projects

FOOT-AND-MOUTH DISEASE VIRUS (FMDV) COUNTERMEASURES DISCOVERY Appropriated (D)   Accession Number: 412008

FOOT-AND-MOUTH DISEASE VIRUS (FMDV) HOST-PATHOGEN INTERACTIONS Appropriated (D)   Accession Number: 411986

COMPARATIVE MODELS OF IMMUNE RESPONSE Grant (G)   Accession Number: 412067

MECHANISMS OF EARLY IMMUNE ENHANCEMENT AGAINST FOOT-AND-MOUTH DISEASE Nonfunded Cooperative Agreement (N)   Accession Number: 411120

EVALUATION OF CYTOKINES TARGETING NATURAL KILLER CELLS OF CATTLE AND SWINE AS POTENTIAL BIOTHERAPEUTICS FOR FOOT-AND-MOUTH DISEASE Reimbursable (R)   Accession Number: 414199

MEASURING IMMUNE RESPONSES TO VACCINATION WITH FOOT-AND-MOUTH DISEASE VIRUS (FMDV) IN CATTLE Specific Cooperative Agreement (S)   Accession Number: 408504

DEVELOPMENT OF FMDV BIOTHERAPEUTICS TARGETING NATURAL KILLER (NK) CELLS OF CATTLE AND SWINE Specific Cooperative Agreement (S)   Accession Number: 414201

IMMUNE RESPONSE AND PATHOGENESIS IN SWINE TO FMDV, VSV AND PRRSV Specific Cooperative Agreement (S)   Accession Number: 405380

TESTING ANTI-VIRAL COMPOUNDS IN COMBINATION WITH VACCINES AGAINST FOOT-AND-MOUTH DISEASE VIRUS (FMDV) AS OUTBREAK INTERVENTION TOOLS Specific Cooperative Agreement (S)   Accession Number: 407623

NOVEL RECOMBINANT ADENOVIRUS VACCINE AND ANTIVIRAL VECTORS TO CONTROL FMDV Specific Cooperative Agreement (S)   Accession Number: 408929

Publications

Characterization of Langerhans Cells in Porcine Skin - (Peer Reviewed Journal) - (09-Jul-08)

Immune Evasion During Foot-and-Mouth Disease Virus (FMDV) Infection of Swine - (Review Article)

Golde, W.T., Nfon, C.K., Toka, F. Immune Evasion During Foot-and-Mouth Disease Virus (FMDV) Infection of Swine. Review Article. (2008) Vol. 225: 85-95.

Type I and II Interferons Activate the Innate Immune System to Promote Early Protection of Swine Against Foot-and-Mouth Disease Virus - (Abstract)

Diaz-San Segundo, F., Moraes, M., De Los Santos, T., Pacheco Tobin, J., Koster, M.J., Dawson, H., Golde, W.T., Grubman, M.J. 2008. Type I and II Interferons Activate the Innate Immune System to Promote Early Protection of Swine Against Foot-and-Mouth Disease Virus. European Study Group on the Molecular Biology of Picornaviruses. P 149

Suppression of Swine NK Cell Function During Acute Infection with Foot-and-Mouth Disease Virus (FMDV) - (Abstract)

Toka, F., Nfon, C.K., Golde, W.T. 2008. Suppression of Swine NK Cell Function During Acute Infection with Foot-and-Mouth Disease Virus (FMDV). European Study Group on the Molecular Biology of Picornaviruses. P 94

Interferon Alpha Production by Circulating Dendritic Cells is Inhibited During Acute Infection with Foot-and-Mouth Disease Virus (FMDV) - (Peer Reviewed Journal)

Nfon, C., Ferman Ii, G.S., Toka, F., Golde, W.T. 2008. Interferon Alpha Production by Circulating Dendritic Cells is Inhibited During Acute Infection with Foot-and-Mouth Disease Virus (FMDV). Viral Immunology. 21:68-77.

Evasion of the Innate Response of Circulation DC Populations by Foot-and-Mouth Disease Virus - (Abstract)

Nfon, C.K., Ferman Ii, G.S., Golde, W.T. 2007. Evasion of the Innate Response of Circulation DC Populations by Foot-and-Mouth Disease Virus. 94th Annual Meeting of The American Association of Immunologists, Inc., P 21

Natural Killer Cells in Foot-and-Mouth Disease Virus Infection - (Abstract)

Toka, F., Nfon, C.K., Endsley, J., Ferman Ii, G.S., Estes, D., Golde, W.T. 2007. Natural Killer Cells in Foot-and-Mouth Disease Virus Infection. 94th Annual Meeting of The American Association of Immunologists, Inc., P 22

Porcine Interferon Gamma Promotes a Protective Innate Immune Response Against Foot-and-Mouth Disease in Swine - (Abstract)

Diaz-San Segundo, F., Moraes, M., De Los Santos, T., Pacheco Tobin, J., Koster, M.J., Turecek, T.E., Dawson, H., Golde, W.T., Grubman, M.J. 2007 Porcine Interferon Gamma Promotes a Protective Innate Immune Response Against Foot-and-Mouth Disease in Swine. American Society for Virology Meeting. W20-3, P. 30

IL-13 REPLACES IL-4 IN DEVELOPMENT OF MONOCYTE DERIVED DENDRITIC CELLS (MODC) OF SWINE; THE INNATE IMMUNE RESPONSE OF MODC TO TOLL-LIKE RECEPTOR AGONISTS - (Peer Reviewed Journal)

Bautista, E.M., Nfon, C., Ferman Ii, G.S., Golde, W.T. 2007. Il-13 replaces il-4 in development of monocyte derived dendritic cells (modc) of swine; the innate immune response of modc to toll-like receptor agonists. Veterinary Immunology and Immunopathology. 115:56-67.

INFECTION WITH FOOT-AND-MOUTH DISEASE VIRUS CAUSES LOSS OF CIRCULATING PLASMACYTOID DENDRITIC CELLS AND ABROGATES THE INTERFERON ALPHA RESPONSE TO TLR AGONISTS - (Abstract)

Golde, W.T., Nfon, C. 2006. Infection with Foot-and-Mouth Disease Virus Causes Loss of Circulating Plasmacytoid Dendritic Cells and Abrogates the Interferon Alpha Response to TLR Agonists. 9th International Conference on Dendritic Cells, September 16, 2006. Poster 4.022, P.89.

NOVEL APPROACH FOR IDENTIFICATION OF CLASS I RESTRICTED T CELL EPITOPES OF FOOT-AND-MOUTH DISEASE VIRUS - (Abstract)

Ferman Ii, G.S., Golde, W.T. 2006. Novel approach for identification of class i restricted t cell epitopes of foot-and-mouth disease virus. Keystone Symposia. 2006 P. 63

DETERMINATION OF ANTIBODY CLASS AND SUBCLASS FOLLOWING FOOT-AND-MOUTH DISEASE VIRUS (FMDV) INFECTION OR VACCINATION WITH KILLED VIRUS VACCINE - (Abstract)

Pacheco, J.M., Ferman Ii, G.S., Golde, W.T. 2006. Determination of antibody class and subclass following foot-and-mouth disease virus (fmdv) infection or vaccination with killed virus vaccine. Keystone Symposia. 2006. P.84

INNATE IMMUNE RESPONSES OF MONOCYTE DERIVED DENDRITIC CELLS (MODC) TO FOOT-AND-MOUTH DISEASE VIRUS (FMDV) - (Abstract)

Nfon, C., Bautista, E.M., Ferman Ii, G.S., Golde, W.T. 2006. Innate immune responses of monocyte derived dendritic cells (modc) to foot-and-mouth disease virus (fmdv). Keystone Symposia. 2006. P.82

IMMUNOPOTENTIATION OF A FOOT-AND-MOUTH DISEASE VIRUS SUBUNIT VACCINE BY INTERFERON ALPHA - (Peer Reviewed Journal)

Botton, S.D., Brum, M.C., Bautista-Peck, E.M., Koster, M.J., Weiblen, R., Golde, W.T., Grubman, M.J. 2006. Immunopotentiation of a foot-and-mouth disease virus subunit vaccine by interferon alpha. Vaccine. (2006) 24: 3446-3456.

A LANCET DESIGNED FOR THE SIMPLE AND HUMANE CHEEK POUCH BLEEDING OF MICE - (Peer Reviewed Journal)

Golde, W.T., Gollobin, P., Rodriguez, L.L. 2005. A Lancet Designed for the Simple and Humane Cheek Pouch Bleeding of Mice. Lab Animal. Vol. 34:9, P. 39-43.

VACCINATION AGAINST FOOT-AND-MOUTH DISEASE VIRUS CONFERS COMPLETE CLINICAL PROTECTION IN 7 DAYS AND PARTIAL PROTECTION IN 4 DAYS:USE IN EMERGENCY OUTBREAK RESPONSE - (Peer Reviewed Journal)

Golde, W.T., Pacheco-Tobin, J., Duque, H., Doel, T., Penfold, B., Ferman Ii, G.S., Gregg, D.A., Rodriguez, L.L. 2005. Vaccination against foot-and-mouth disease virus confers complete clinical protection in 7 days and partial protection in 4 days:use in emergency outbreak response. Vaccine 23 (2005) 5775-5782.

RAPID PROTECTION OF CATTLE FROM DIRECT CHALLENGE WITH FOOT-AND-MOUTH DISEASE VIRUS (FMDV) BY A SINGLE INOCULAITON WITH AN ADENOVIRUS VECTORED FMDV SUBUNIT VACCINE - (Peer Reviewed Journal)

Pacheco, J., Brum, M., Moraes, M., Golde, W.T., Grubman, M.J. 2005. Rapid Protection of Cattle from Direct Challenge with Foot-and-Mouth Disease Virus (FMDV) by a Single Inoculaiton with an Adenovirus Vectored FMDV Subunit Vaccine. Virology. 337: P205-209.

DIFFERENCE OF ANTIBODY ISOTYPE (IGA) PRODUCTION AFTER FOOT-AND-MOUTH DISEASE VIRUS VACCINATION OR INFECTION IN PIGS - (Abstract)

Pacheco, J.M., Ferman Ii, G.S., Golde, W.T. 2005. Difference of Antibody Isotype (IGA) Production after Foot-and-Mouth Disease Virus Vaccination or Infection in Pigs. American Society for Virology 24th Annual Meeting. P. P18-1.

RAPID PROTECTION OF CATTLE FROM DIRECT CHALLENGE WITH FOOT-AND-MOUTH DISEASE VIRUS (FMDV) BY INOCULATION WITH AN ADENOVIRUS VECTORED FMDV SUBUNIT VACCINE - (Abstract)

Moraes, M., Pacheco, J., Brum, M., Golde, W.T., Grubman, M.J. 2005. Rapid Protection of Cattle from Direct Challenge with Foot-and-Mouth Disease Virus (FMDV) by Inoculation with an Adenovirus Vectored FMDV Subunit Vaccine. American Society for Virology 24th Annual Meeting. P. P9-5.

RAPID PROTECTION OF CATTLE FROM DIRECT CHALLENGE WITH FOOT-AND-MOUTH DISEASE VIRUS (FMDV) BY INOCULATION WITH AN ADENOVIRUS VECTORED FMDV SUBUNIT VACCINE - (Abstract)

Pacheco, J.M., Brum, M.C., Moraes, M.P., Golde, W.T., Grubman, M.J. 2005. Rapid Protection of Cattle from Direct Challenge with Foot-and-Mouth Disease Virus (FMDV) by Inoculation with an Adenovirus Vectored FMDV Subunit Vaccine. European Study Group on the Molecular Biology of Picornaviruses (ERUOPIC) 2005. P. I22.

NOVEL TOOLS TO PREVENT AND ERADICATE FOREIGN ANIMAL DISEASES - (Abstract)

Rodriguez, L.L., Baxt, B., Rieder, A.E., Golde, W.T., Borca, M.V., Grubman, M.J. 2005. Novel tools to prevent and eradicate foreign animal diseases. American Society for Microbiology Biodefense Meeting. p 41.

PORCINE IL-13 REPLACES IL-4 IN DEVELOPMENT OF DENDRITIC CELLS FROM PERIPHERAL BLOOD - (Proceedings/Symposium)

Bautista Peck, E.M., Ferman Ii, G.S., Golde, W.T. 2005. Porcine IL-13 Replaces IL-4 in Development of Dendritic Cells from Peripheral Blood. Annual Meeting of the American Society of Immunology, Experimental Biology 2005. 256.1, P. 97.

CONSTITUTIVE EXPRESSION OF IFN-ALPHA BY PORCINE SKIN DENDRITIC CELLS CONFERS RESISTANCE TO INFECTION BY FOOT-AND-MOUTH DISEASE VIRUS (FMDV) - (Peer Reviewed Journal)

Bautista Peck, E.M., Ferman Ii, G.S., Gregg, D.A., Brum, M.C., Grubman, M.J., Golde, W.T. 2005. Constitutive Expression of IFN-alpha by Porcine Skin Dendritic Cells Confers Resistance to Infection by Foot-and-Mouth Disease Virus (FMDV). Journal of Virology 79 (8). P 4838-4847.

THE EFFECT OF GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR ON THE EFFICACY OF A FOOT-AND-MOUTH DISEASE VIRUS SUBUNIT VACCINE - (Peer Reviewed Journal) - (04-Nov-04)

CROSS REACTION OF ANTI-HUMAN CD MONOCLONAL ANTIBODIES ON SWINE CELLS: A SUMMARY OF THE SWINE SECTON OF THE HLDA8 ANIMAL HOMOLOGUES DATA - (Abstract)

Lunney, J.K., Aasted, B., Dominguez, J., Alvarez, B., Revilla, C., Ezquerra, A., Alonso, F., Haverson, K., Golde, W.T., Kuhar, D.J. 2004. Cross reaction of anti-human cd monoclonal antibodies on swine cells: a summary of the swine secton of the hlda8 animal homologues data. Meeting Abstract.

EARLY DEVELOPMENT OF ADENOVIRUS-VECTORED FMD VACCINE AND ANTIVIRAL - (Abstract)

Grubman, M.J., Golde, W.T., Rodriguez, L.L. 2004. Early development of adenovirus-vectored fmd vaccine and antiviral. Meeting Abstract.

VESICULAR STOMATITIS NEW JERSEY VIRUS IN CATTLE: PATHOGENESIS, VIRUS DISTRIBUTION AND LOCAL IMMUNE RESPONSE - (Abstract)

Scherer, C.F., Golde, W.T., Gregg, D.A., Estes, D.M., Drolet, B.S., Rodriguez, L.L. 2004. Vesicular Stomatitis New Jersey Virus in Cattle: Pathogenesis, Virus Distribution and Local Immune Response. Conference of Research Workers in Animal Disease Annual Meeting. P. 198.

EARLY DEVELOPMENT OF ADENOVIRUS-VECTORED FMD VACCINE AND ANTIVIRAL - (Abstract)

Grubman, M.J., Golde, W.T., Rodriguez, L.L. 2004. Early Development of Adenovirus-vectored FMD Vaccine and Antiviral. European Commission for the Control of Foot-and-Mouth Disease, Chania, Crete, Greece. P. 45.

INTERACTIONS OF FOOT-AND-MOUTH DISEASE VIRUS WITH SOLUBLE BOVINE ALPHAVBETA3 AND ALPHAVBETA6 INTEGRINS - (Peer Reviewed Journal)

Duque, H., Larocco, M., Golde, W.T., Baxt, B. 2004. Interactions of foot-and-mouth disease virus with soluble bovine alphavbeta3 and alphavbeta6 integrins. Journal of Virology. 78:9773-9781.

A SYNTHETIC PEPTIDE CONTAINING THE CONSENSUS SEQUENCE OF THE G-H LOOP REGION OF FMDV TYPE O VP1 COMBINED WITH A PROMISCUOUS T-HELPER EPITOPE INDUCES PEPTIDE-SPECIFIC AB BUT FAILS TO PROTECT CATTLE AGAINST VIRAL CHALLENGE - (Peer Reviewed Journal)

RODRIGUEZ, L.L., BARRERA, J.D., KRAMER, E., LUBROTH, J., BROWN, F., GOLDE, W.T. A SYNTHETIC PEPTIDE CONTAINING THE CONSENSUS SEQUENCE OF THE G-H LOOP REGION OF FMDV TYPE O VP1 COMBINED WITH A PROMISCUOUS T-HELPER EPITOPE INDUCES PEPTIDE-SPECIFIC AB BUT FAILS TO PROTECT CATTLE AGAINST VIRAL CHALLENGE. VACCINE, VOLUME 21: 3751-3756, 2003.

INDUCTION OF LYMPHOPENIA AND INHIBIITION OF T CELL FUNCTION DURING ACUTE INFECTION OF SWINE WITH FOOT AND MOUTH DISEASE VIRUS (FMDV) - (Peer Reviewed Journal)

BAUTISTA, E.M., FERMAN II, G.S., GOLDE, W.T. INDUCTION OF LYMPHOPENIA AND INHIBIITION OF T CELL FUNCTION DURING ACUTE INFECTION OF SWINE WITH FOOT AND MOUTH DISEASE VIRUS (FMDV). VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY. Vol 92: 61-73, 2003.