|
|
Funding Agency:
Department of Defense (DoD)
On-going Research Projects:
This project will determine the effectiveness of newer pharmaceutical fatigue countermeasures.
This project addresses a common condition, facial nerve weakness, that currently has no satisfactory treatment for many patients.
This research project plans to design, prototype, and test a new assistive device to restore the ability to climb stairs and walk to individuals with paraplegia.
This research will study the effects of propranolol administered in combination with tramatic memory reactivation as a potential treatment for PTSD.
This study will test to determine if mifepristone improves the health of Gulf War veterans with chronic multisymptom illness (CMI).
This research will investigate the effectiveness of citalopram as a treatment for generalized anxiety disorder after traumatic brain injury (TBI).
This research will continue to study a possible treatment for paralysis.
This project will initiate developments for a new vaccine to prevent malaria.
This project will attempt to shed light on the mechanisms of Gulf War illness and test drugs that might lead to effective treatments.
This project will attempt to identify new biomarkers to allow an early and more specific diagnosis of ALS.
This research will try to identify genetic biomarkers of risk for PTSD.
This project will test for possible genetic indicators of Gulf War Illness (GWI).
This project proposes to determine if alloys tungsten/nickel/cobalt and tungsten/nickel/iron cause cancer in mice.
This research has the potential to improve the safety of current spine surgery techniques and would offer an alterative to patients who require spine fusion but are not candidates for major surgery.
This project will conduct research to develop a vaccine to prevent hemorrhagic fever with kidney syndrome.
The Defense and Veterans Brain Injury Center engages in research to enhance the quality, appropriateness, timeliness, and cost-effectives of treatment for active duty military, their dependents and veterans with traumatic brain injury.
This research will design and develop stable, infection-free skeletal implants for above-the-knee amputees.
The goal of this research is to develop an effective controlled local pain management delivery system for the treatment of orthopaedic trauma.
This project is developing a vaccine to protect military personnel against malaria infection.
This project will conduct studies to develop a diagnostic system or tool to identify various infectious diseases.
This project will determine if there is a relationship between a specific gene (TAU) and the development of amyotrophic lateral sclerosis (ALS).
This registry was established to capture comprehensive data on healthcare utilization to calculate the prevalence of birth defects among children born to military families.
This study will compare the effectiveness of various types of early intervention (debriefing, information, cognitive-behavioral) following a potentially traumatizing event, in order to develop valid methods to improve soldier resilience after such events.
This animal study will determine if morphine and trauma increase the potential for acinetobacter baumannii infection.
This project will investigate two different interventions for sleep disturbances associated with PTSD in men and women veterans.
The focus of this research is to develop vaccines against viruses such as Dengue, Japanese Encephalitis, and Tick-Borne Encephalitis.
This project will review the function of specific receptors in the nervous system to determine their role in the progression of amytrophic lateral sclerosis (ALS).
This research program conducts and manages research on potential vaccines and treatments to protect US forces from HIV.
The focus of this research is to develop vaccines and treatments for hemorrhagic fever infections and diseases such as Ebola, Lassa, Marburg, and Crimean-Congo hemorrhagic fevers[CCHFV])hemorrhagic fever.
This project will conduct research to improve the prevention of infectious diseases such as malaria, dengue, and leishmaniasis.
This research is designed to identify therapeutic regimens that will prevent vision loss and inflammation following post-traumatic infection by Bacillus endophthalmitis.
This research may be useful in treating eye injuries after trauma such as with shrapnel or Improvised Explosive Devices to prevent development of or induce regression of abnormal blood vessels in the cornea in an effort to help restore or preserve vision.
The focus of this research is to develop a diagnostic device to detect leishmaniasis infection.
This research will measure deployment experiences (such as combat exposure, other deployment-related stressors, perceptions of unit support, and use of in-theater combat stress interventions) and post-deployment psychiatric distress, quality of life, life stressors, mental health service utilization, and military retention/attrition over the course of 2 years.
This project will conduct research to support the development of new malaria drugs.
This project will test antimalarial drugs.
The focus of this research is to develop vaccines to prevent malaria.
The anticipated outcomes of this research are to identify several proteins that react with nerve agents and to provide a new method for detecting nerve agent exposure.
This project aims to investigate the development of new therapeutic strategies to prevent corneal transplant rejection.
This project will examine biological and psychological alterations in veterans with post-traumatic stress disorder (PTSD) before and after treatment.
This animal project will test the strategy of nitroxide resuscitation to treat traumatic brain injury (TBI) and hemorrhagic shock.
This animal study will look at potential treatments for neurotoxicity caused by chronic exposure to depleted uranium.
This study is an innovative use of Internet-based technology and may provide a unique early combat-related PTSD intervention and resilience training option for military personnel and veterans seeking primary care after experiencing combat-related stressors.
This research will develop a treatment for several forms of retinal blindness by using retinal prosethesis.
This animal study will determine if treatment with diabetes medications prevent or reduce the development of organ dysfunction, immuno-suppression, and death following major injuries.
This study will give us some of the information needed to target treatment of PTSD in soldiers that need help to be able to appropriately function in the military or civilian worlds.
This study will determine if topiramate- an antiepileptic drug (AED)- administered immediately after traumatic brain injury (TBI) reduces early seizures, diminishes the development of late epilepsy, and facilitates recovery from TBI.
This project will conduct research to develop vaccines to prevent malaria.
This study will focus on the biology of bacteria that cause diarrheal diseases and the development of potential vaccines to prevent diarrheal diseases.
This study will examine whether men who served in the military during World War II, Korea, or Vietnam have a high risk of amyotrophic lateral sclerosis (ALS) as compared with men who did not serve.
This research will work towards developing new malaria vaccine and drug targets.
This project will determine if administering coenzyme Q10 (Q10) to Gulf War veterans reduces their symptoms and improves their health.
This project will try to determine if the environmental medicine approach is able in relieve symptoms in ill Gulf War veterans.
This project plans to develop a technique to quickly identify microorganisms responsible for wound infections.
This research will focus on bioengineering the stem cell-based corneal constructs for therapeutic repair of corneal injury to restore vision.
This research focuses on the development of a vaccine to prevent rickettsial diseases.
This research will contribute to improving the outcomes and quality of life for civilian and military personnel with lower extremity limb trauma.
This study will identify opportunities to help military families experiencing violence and/or substance abuse.
This follow-up brain imaging study will evaluate the combination of exposures such as pesticides as possible factors for continued symptoms in Gulf War veterans.
This ongoing study (Millennium Cohort Study) will use periodic surveys to track changes in the health of a large group of US service members and veterans over time to determine the health impact of deployments and other aspects of military service.
This study will determine if soft coral is able to assist in healing wounds.
This project will review potential mechanisms which may promote recovery of function in traumatic brain injury patients.
This research will test whether a specific family of molecules (neurotrophic growth factors) can protect retinal neurons from dying after exposure to a harmful dose of laser energy.
This research will investigate a new class of drugs for the treatment and/or prevention of chronic pain associated with spinal cord injury.
This project will conduct studies on how to design and test HIV vaccine candidates.
This research focuses on developing a vaccine for meningitis.
This project will test a potential treatment for severe malaria.
This research will focus on reducing the impact of diarrheal diseases on military operations.
This research will assess the potential risk of injury of current protective equipment for Soldiers.
Completed Research Projects:
This project tested a potential new method to assist in healing war wounds.
The study compared health problems of Gulf War Veterans to Vietnam Veterans to see if there was a general relationship between health problems and exposure to a combat environment.
This study compared the unexplained illnesses and symptoms of three United Kingdom military groups -- Gulf War-era deployed veterans, Gulf War-era non-deployed veterans, and Bosnia Conflict deployed veterans.
This project's objective was to develop a simple, field-deployable system to detect biological toxins.
This study was designed to develop a better testing method to detect and measure exposure to nerve agents.
This project reviewed the long-term outcomes among patients with mild TBI.
This is the parent Program for DOD projects 1A through 1G.
This project conducted a clinical trial to determine how effective Prazosin compared to Paroxetine is for combat stress-induced PTSD nightmares and sleep disturbance.
This study evaluated the efficacy of cognitive-behavioral therapy (CBT) for post-traumatic stress disorder (PTSD) in women.
This study reviewed two different types of treatment for women with military-related posttraumatic stress disorder (PTSD).
This project compared the efficacy of two pain programs- the Interdisciplinary Chronic Pain Rehabilitation Program (ICPRP) and Standard Treatment Control Group (a standard anesthesiology pain clinic)- with military personnel suffering from musculoskeletal disorders.
This study looked at whether or not cognitive behavioral therapy (CBT) and aerobic exercise, alone or in combination, are better than regular care for Gulf War veterans with chronic unexplained symptoms.
This study re-tested an earlier group of Gulf War veterans for changes in behavior or brain function and compared them to non-deployed veterans.
The purpose of this study was to determine the effectiveness of acupuncture as a treatment for Posttraumatic Stress Disorder (PTSD) among military personnel.
This study looked at the short and long-term impact of deployment to Southwest Asia on the physical and mental health of soldiers and their families.
This study reviewed how many Gulf War veterans have amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease).
This study gained a better understanding of the potential effects that pesticides and the use of PB tablets may have had on an individual's post-war health.
This study looked to see if there was any correlation between systemic coccal disease (SCD) and unexplained illnesses of some Gulf War veterans.
This study was designed to determine whether or not antibiotic treatment of ill Gulf War veterans would improve their physical functioning.
This study attempted to establish an effective way to test for squalene antibodies and to determine if these antibodies are present in ill Gulf War veterans.
This study used existing health records to compare the health of Saudi military members stationed in a combat area during the Gulf War with military members stationed in a non-combat area.
The study was designed to determine if a gene instability exist in Gulf War veterans.
This study exposed lab rats to low levels of sarin, a nerve agent, to determine if there were any disease or behavioral effects in the brain.
This pilot study tested blood samples from service members before and after the Gulf War for chemical warfare agents, pesticides, and smoke components.
This animal study was designed to evaluate effects of exposure to pyridostigmine bromide, permethrin, DEET, stress, and vaccinations.
This study looked at how the nervous system reacts to stress.
This research developed a live vaccine "vehicle" that could easily be adapted to different bioterrorism agents.
This animal study evaluated the effects of low-level exposure to chemicals such as pesticides.
This project reviewed biomedical markers capable of distinguishing between traumatic and oxygen-deprived brain injury.
This study developed an animal model to determine the effects of a blast-induced brain injury.
This study in animals evaluated how uranium in the blood may be transported into the brain to help determine whether veterans with embedded depleted uranium fragments are at risk for developing nervous system toxicity as a result of uranium accumulation in the brain.
This study tested the theory that unexplained illnesses of Gulf War veterans is a result of damage caused by exposure to nerve agents.
This study measured and compared the blood and spinal fluid of ill and healthy Gulf War veterans.
This animal study looked at whether or not embedded fragments of depleted uranium (DU) cause changes in cells of the body.
This study in animals evaluated the potential for embedded depleted uranium fragments to cause cancer and changes in the immune system, in order to help determine whether or not long-term exposures are harmful.
This animal study tested the effects of tissue-embedded depleted uranium fragments.
This study looked at fatal motor vehicle crashes among Gulf War veterans who deployed to those who were not deployed.
This study reviewed the exposure to in-tent pollutants by measuring chemicals in the air while using kerosene heaters.
This was a comprehensive effort to understand how organophosphate exposure affects cognitive and neurological functions.
This animal project tested the effects of depleted uranium on reproduction.
This animal study evaluated the effects of low-level exposure to chemicals like pesticides.
This study reviewed the possibility of a unique Gulf War illness.
This study looked at the possible relationship between a certain protein and post-traumatic stress disorder (PTSD) in Vietnam War veterans.
This study performed a combined analysis of two clinical registries on Gulf War veterans: the DOD's Comprehensive Clinical Evaluation Program and the VA's Gulf War Health Examination Registry.
This study compared the cause and rate of death between Gulf War era deployed and non-deployed veterans.
This study compared virtual reality therapy to the current standard treatment- combination of medications and cognitive behavior therapy- for treating acute PTSD.
This animal study evaluated the effects of implanted depleted uranium.
This project established the Deployment Health Research Center to conduct epidemiological research relevant to military personnel.
This project tested the Intravenous Membrane Oxygenator (IMO) in lung-injured animal models.
This study reviewed if the current multifocal electroretinogram (MERG) was able to accurately determine the effects from a laser eye injury.
This project was designed to develop a testing method to detect changes in brain function (thinking and learning) before, during, and after deployment.
This study was designed to develop screening tests and treatments for military personnel infected by leishmania.
The purpose of this study was to develop a skin test for leishmaniasis that would help diagnose this infection in Gulf War veterans and others who may have been exposed.
This animal study looked at methods that could be used in the field to estimate the human exposure to the chemical agent mustard.
This study was designed to develop a laboratory test to detect leishmaniasis infection in military personnel.
This study compared the failure of the body to properly adjust to standing up in individuals with and without adverse health affects attributed to GW deployment.
This research compared military personnel who received the smallpox vaccination to those who did not receive the vaccination.
This study reviewed the hospitalizations of military personnel to determine if there was a relationship between anthrax immunization and severe diseases requiring hospitalization.
This study looked at Gulf War veterans who reported unexplained symptoms.
This project studied the effects of stress on brain structure and function and the potential influence of chronic alcohol abuse.
This study compared the health of Gulf War deployed and non-deployed military working dogs.
This animal study tested the effects of pyridostigmine bromide (PB).
This project reviewed the effects of helmet configuration on the rate of head injury.
This study compared post-war symptoms and diseases of Gulf War-era deployed veterans to non-deployed veterans.
This study compared hospitalizations of Gulf War-era deployed veterans to non-deployed veterans.
This study reviewed pregnancy outcomes of Gulf War era deployed and non-deployed veterans.
The study compared reproductive outcomes, eg. miscarriages, early pregnancy loss, premature birth, and low birth weight between Gulf War-era deployed and non-deployed veterans.
This study compared symptoms and illnesses between Gulf War veterans and other veterans.
This study compared hospitalizations between Gulf War-era deployed to non-deployed veterans.
This study compared birth defects in infants born to Gulf War-era deployed veterans to non-deployed veterans and the general population.
This study compared the general health of Gulf War era women who deployed to those who did not deploy.
This study looked at causes of ongoing chronic fatigue and muscle weakness in Gulf War veterans.
This study compared immune responses and health effects in recruits who underwent multiple, simultaneous vaccination schedule with recruits on a staggered vaccination schedule.
This project developed an animal model to examine the toxicological and behavorial effects of depleted uranium on female rats.
This study looked at whether or not embedded fragments of depleted uranium (DU) alter the ability of female animals to conceive and produce healthy offspring.
This mouse study tested the effects of exposure to DEET, pyridostigmine bromide, and JP-8 jet fuel on the immune system.
This study evaluated current animal models to test the health effects of various chemical exposures.
This project reviewed the Comprehensive Clinical Evaluation Program (CCEP) database to develop a general computer package that can be used to gather general health and symptom information related to Gulf War service.
This study looked at fatigue among Gulf war veterans.
This study examined the possibility of developing a database of veteran sibling pairs to look at possible genetic associations with PTSD.
This was study to determine how to monitor birth defects among active and reserve military personnel.
This study looked at Gulf War Veterans to determine if any risk factors exist that may pre-dispose a person to multiple chemical sensitivities syndrome.
This project demonstrated the effectiveness of a heat tolerance test kit.
The study examined self-reported health assessments of Army personnel, who assumed exposure to low levels of chemical warfare agents compared to those not exposed.
This pilot study surveyed individuals exposed to chemical agents for common neurological and mental health disorders to determine whether or not a full study of health effects on exposed individuals can be done.
This project investigated potential therapies for ALS.
This project reviewed potential causes of undiagnosed Gulf War illness and developed methods for efficient diagnosis and treatment.
This study will help to determine if potentially hazardous exposures faced during deployment increases the number of adverse health outcomes in the offspring of OIF/OEF deployers.
This animal study tested the effects of embedded depleted uranium fragments.
This study reviewed the health of a group of national guard members to learn more about the health effects of deployments, job strain, and other factors.
This study looked at the effects of deployment-related chemicals.
This study was designed to develop a method for testing blood or urine to detect and monitor exposure to the pesticide permethrin.
This study was designed to identify the genes in Leishmania related to temperature sensitivity.
This study compared confirmed illnesses of Gulf War veterans to veterans who did not deploy to the Gulf.
This study combined UK (United Kingdom) and US databases of information about symptoms, medical conditions, health status, and risk factors to compare the findings and better understand the health impact of the Gulf War deployment.
This animal study looked at the effects of DEET and pyridostigmine bromide with increased levels of physical stress.
This animal study looked at whether or not embedded fragments of depleted uranium (DU) caused the immune system to not work properly.
This project studied "post-deployment" soldiers of OEF/OIF.
This project evaluated whether brain wave recordings could measure the impact of long and short deployments on soldiers.
This study was designed to develop a new blood test to better determine the effects from a chemical exposure.
This study evaluted the effects of pyridostigmine bromide on the normal functions of the body.
This animal study evaluated the potential for inhaled uranium oxide (from combustion of depleted uranium) to enter the brain through the nose and cause nervous system damage.
This animal study tested the effects of low level exposure of sarin and pyridostigmine bromide (PB) on the brain and nervous system functions of rats.
This study looked at Gulf War veterans and their sexual partners who experienced a burning sensation after contact with semen.
This project tested a military health questionnaire and determined its potential for DoD-wide implementation as the Recruit Assessment Program (RAP).
This study looked at the health of US troops and civilian employees exposed to Kuwait oil fires.
This study reviewed Kuwait oil fire Health Risk Assessment data of US troops located at eight fixed air/soil sampling sites.
This study used an imaging technique to determine if there was a relationship between certain brain activity and post-traumatic stress disorder (PTSD) in Vietnam War-era veterans.
This study looked at the long-term effects to low level exposure to the nerve agent, sarin.
This animal study looked at the possible long-term effects of low-level exposure to the nerve agent sarin, alone or in combination with stress, pyridostigmine bromide, and DEET.
This study assessed the health status of Gulf War veterans and non-Gulf War veterans to determine if the Gulf War veterans health status are better, worse or the same as non-Gulf War veterans ten or more years after the war.
This study was designed to develop a test to detect low-level exposure to sulfur mustard (a chemical warfare agent) in skin and blood samples.
This animal study looked at low-level exposure to the nerve agent sarin.
This study looked at the long-term or delayed effects of exposures to the nerve agent sarin with and without the pre-treatment tablet pyridostigmine bromide.
This study interviewed and examined groups of Gulf War veterans with and without unexplained illnesses to determine whether abnormalities in the brain imaging of ill Gulf War veterans (by magnetic resonance spectroscopy), occur independently of posttraumatic stress disorder, alcohol dependence, and depression.
This study compared the effects of pyridostigmine bromide (PB) on men and women.
This study compared self-reported symptoms and health-related quality of life among Gulf War veterans to determine if these factors could be associated with deployment.
The purpose of this study was to increase the understanding of the body's response to multiple vaccines and the potential implications for future deployed populations.
These studies assessed the long-term effects of mild, moderate, and severe traumatic brain injury.
This project studied the mechanisms of three prominent symptoms (pain, fatigue, and memory difficulty) associated with Fibromyalgia, Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, and illnesses of Gulf War veterans.
This animal study investigated the effects of insecticide exposure on asthma.
This project designed a minirobot to perform surgery in the battlefield.
This study looked at how the body deals with stress.
This project reviewed potential methods to prevent eye injury in the battlefield.
This study looked at specific sites and nature of brain damage in a sample of Gulf War Veterans.
This study in animals was designed to evaluate the uptake, distribution, and retention of depleted uranium in the brain in the presence and absence of stress, and to examine changes following short and long-term exposure, in order to better understand the potential nervous system toxicity of uranium.
This task created a registry to track combat casualty events.
This animal study tested brain and immune functions of rats after they were exposed to pyridostigmine bromide (PB), permethrin, and DEET.
This animal study investigated the effects of sarin on the central nervous and the immune systems.
This study was designed to determine if the development of post-traumatic stress disorder requires both a traumatic event and a genetic increased risk.
This animal study looked at the effects of low level exposures of sarin, pyridostigmine bromide, pesticides, and botulinum toxoid in monkeys.
This animal study looked at the ability of rats brains to recover function after being exposed to stress.
This study evaluated the combination of pesticides, low-level chemical exposures, and stress as factors in the expression of veterans' continued symptoms.
This study evaluated the brain function and mental health of some Gulf War veterans who sought treatment.
This animal study tested the effects of chronic exposure to depleted uranium on brain function.
This project reviewed new targets for future treatments of leishmaniasis and malaria.
This study in humans was designed to evaluate whether or not the unexplained symptoms of Gulf War veterans is caused by a conditioned response to chemical odors.
This study looked to support or dismiss the theory that Gulf War Veterans had nervous-system deficits consistent with prior exposure to organophosphorous chemicals.
This pilot study reviewed health records prior to the Gulf War deployment to see if patterns of illness or healthcare usage were different in individuals who later developed poorly defined illnesses.
This project compared patterns of illness and use of the Department of Defense outpatient care during the year prior to deployment to the Persian Gulf War personnel who developed poorly defined illnesses.
This pilot study reviewed health records before and after the Gulf War deployment to see if there were patterns of illness in individuals.
The animal study evaluated the effects of DEET, permethrin, pyridostigmine bromide and jet fuel on pig skin.
This study reviewed the effects of environmental and occupational exposures on Gulf War veterans.
This study compared health problems between female veterans deployed to the Gulf War and those deployed elsewhere.
This study compared the physical, social, mental, and family health of Gulf War veterans to military personnel who deployed and did not deploy to other regions of the world.
This study looked at the association between Persian Gulf War illness and stress among women who served in the Persian Gulf War.
This study tested the effects of diesel, jet fuel, DEET, and pyridostigmine bromide (PB) on rats.
This study developed and evaluated an intervention for smokeless tobacco cessation.
This study compared the health status of deployed and non-deployed Gulf War era veterans.
This animal study investigated if male mice with embedded fragments of depleted uranium transmitted genetic damage to their offspring.
This study surveyed reserve and National Guard members before, during, and after deployment to Bosnia.
This research reviewed the daily water needs of soliders working in hostile environments.
This project reviewed the questions on the survey given to all new Navy enlistees.
This project was conduted to improve understanding of the long-term consequences of alcohol problems on injury risk.
This study reviewed several novel treatments to prevent post-traumatic epilepsy associated with penetrating brain injury.
This is the parent program for DOD projects DOD-8A and DOD-8B.
This study compared pre and post-deployment health status of military personnel deployed to the Middle East. (See also DOD-154)
This study compared pre and post-deployment health status of military personnel deployed to the Middle East. (See also VA-88)
This study compared brain functions of Vietnam veterans to Gulf War veterans.
This study was designed to develop and test a mental health screening tool for soldiers throughout their deployment cycle.
This study looked at the effects of stress from war-related trauma on Gulf War veterans over time.
This animal study tested the effects of pyridostigmine bromide (PB), permethrin, and DEET given in combination and at the same time to rats.
This animal study administered pyridostigmine bromide in various doses to see if any damage occured in the brain.
This study evaluated the effects of pyridostigmine bromide, permethrin, DEET, and stress on brain functions.
This study used a Firearm Training Simulator (FATS) as part of the rehabilitation for upper extremity injuries.
This study looked at the relationship between Gulf War illness and stress exposures experienced by Gulf War veterans.
This study evaluated the effects of pyridosigmine bromide (PB) use during the Gulf War.
| |
