Technical Abstract: Fusarium head blight (FHB) is a devastating disease of wheat and barley worldwide. Resistant cultivars could reduce damage from FHB. Chinese wheat cultivar Sumai 3 and its derivatives represent the greatest degree of resistance to FHB known. A major QTL on chromosome 3BS and other minor QTL for FHB resistance have been identified in these cultivars and used in wheat breeding programs worldwide. Many breeding lines with the 3BS resistance QTL and improved agronomic traits have been developed. In barley, only limited sources of FHB resistance are available, especially in 6-rowed barley, and none of them contains a DON level low enough to meet the safety requirement of the brewing industry. Several QTL have been identified for lower FHB severity, DON content and kernel discoloration and used to enhance barley FHB resistance. Marker-assisted selection for FHB resistance QTL on 3BS of wheat and on 2H of barley is in progress.