National Cancer Institute National Cancer Institute
U.S. National Institutes of Health National Cancer Institute
NCI Home Cancer Topics Clinical Trials Cancer Statistics Research & Funding News About NCI
Pain (PDQ®)
Patient VersionHealth Professional VersionEn españolLast Modified: 10/29/2008
Advantages and Disadvantages of Intraspinal Drug Administration

System   Advantages   Disadvantages 
Percutaneous temporary catheter Used extensively both intraoperatively and postoperatively. Mechanical problems include catheter dislodgment, kinking, or migration.
Useful when prognosis is limited (<1 month). Increased risk of infection.
Permanent silicone-rubber epidural Catheter implantation is a minor procedure.
Dislodgment and infection less common than with temporary catheters.
Can deliver bolus injections, continuous infusions, or PCA (with or without continuous delivery).
Subcutaneous implanted injection port Increased stability, less risk of dislodgment. Implantation more invasive than external catheters.
Can deliver bolus injections or continuous infusions (with or without PCA). Approved only for epidural catheter in United States.
Potential for infection increases with frequent injections.
Subcutaneous reservoir Potentially reduced infection in comparison with external system. Difficult to access, and fibrosis may occur after repeated injection.
Implanted pumps (continuous and programmable) Potentially decreased risk of infection. Need for more extensive operative procedure.
Need for specialized equipment with programmable systems.


A Service of the National Cancer Institute
Department of Health and Human Services National Institutes of Health USA.gov