Jump to main content.

Research Project Search
 Enter Search Term:
   
 NCER Advanced Search

Aerobic Cometabolism of Ether-bonded Compounds

EPA Grant Number: R823426
Title: Aerobic Cometabolism of Ether-bonded Compounds
Investigators: Hyman, Michael R.
Institution: Oregon State University
Current Institution: Oregon State University , North Carolina State University
EPA Project Officer: Manty, Dale
Project Period: October 1, 1995 through September 1, 1998
Project Amount: $358,953
RFA: Exploratory Research - Environmental Biology (1995)
Research Category: Biology/Life Sciences

Description:

The overall aim of the research in this proposal is to characterize the microbial potential for the cometabolic degradation of a range of simple either-bonded compounds. The proposed research logically falls into four sections. First, we aim to examine what are the structural features of simple alkyl, alicyclic and aromatic ethers which dictate the reactivity of ether-bonded compounds towards non-specific microbial monooxygenase enzymes. These studies will be conducted with the soil nitrifying bacterium Nitrosomonas europaea which possesses a highly non-specific monooxygenase, ammonia monooxygenase. This microorganism also cannot further metabolize most organic substrates and this feature greatly assists in determining reaction pathways. The specific aims are: 1) to establish both the maximal rate of ether degradation and the products of those reactions; 2) to determine the oxidation products of a selected range of ether compounds which are recognized as environmental pollutants. These include chlorinated alkyl ethers, halogenated aryl ethers and dibenzo-p-dioxin; and 3) to establish how widely distributed this cometabolic capability for ether degradation and O-dealkylation is distributed in other microorganisms.

Completion of the proposed research will provide the first comprehensive analysis of the microbial cometabolic degradation of many simple ether compounds. The data will provide details of the structural features which determine ether reactivity, the products and pathways of cometabolic ether degradation and the relative rates of ether degradation catalyzed by diverse groups of microorganisms. These data will also provide insight into the possible environmental fate of two important classes of Priority Pollutants. Furthermore, these studies could also assist in the development of biocontrol or bioremediation procedures for ether-bonded compounds.

Publications and Presentations:

Publications have been submitted on this project: View all 12 publications for this project

Journal Articles:

Journal Articles have been submitted on this project: View all 1 journal articles for this project

Supplemental Keywords:

Ecosystem Protection/Environmental Exposure & Risk, Toxics, Scientific Discipline, Waste, Biology, Biochemistry, Environmental Microbiology, Fate & Transport, pesticides, Bioremediation, dioxins, aromatic pollutants, fate and transport, microbial degradation, aerobic cometabolism, soil nitrifying bacterium, enzymes, ether bonded compounds, contaminant release, contaminants in soil, microbiology, dioxin, reaction pathways

Progress and Final Reports:
1997 Progress Report
Final Report

Top of page

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

Local Navigation

Jump to main content.