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Research Project:
STRUCTURE-ACTIVITY STUDIES OF KNOWN ARTHROPOD REPELLENTS USING CODESSA
Location: Mosquito and Fly Research Unit
Project Number: 6615-32000-043-02
Project Type:
Specific Cooperative Agreement
Start Date: Aug 05, 2004
End Date: Jul 14, 2009
Objective:
The objective of this cooperative research project is: To predict the structures of novel chemical repellents for mosquitoes and flies that bite humans, by computerized evaluation of a large USDA-exclusive data base consisting of two classes of known and tested repellents. Analyze a data base of organic compounds (piperidines and oxazolidines), and the synthesis of a small amount of organic compounds to be tested as insect repellents.
Approach:
Analyze a data base of organic compounds that were previously synthesized and tested against specific insect species for their repellent character, and predict new structures that should be active. A sophisticated modern computer system, CODESSA PRO, will be employed to develop quantitative structure activity/property relationships (QSAR/QSPR) to define and improve mosquito and fly chemical repellents. Modify known procedures to synthesize a series of specific structurally related organic piperdine amides in the amount of 50 to 100 mg each, purify for delivery to CMAVE laboratory.
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Last Modified: 11/07/2008
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