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IRIS Toxicological Review of Beryllium (External Review Draft)

Contact
Amanda Persad
by phone at:   919-541-9781
by fax at:   919-541-2985
by email at:  persad.amanda@epa.gov

Notice

EPA announces the release of the updated cancer assessment in the Toxicological Review of Beryllium and notice of the External Peer Review Panel Meeting in the May 12, 2008 Federal Register Notice. This draft assessment is provided for public viewing and comment. Public comments received on the Toxicological Review within 60 days after the release of the FRN will be provided to the external peer reviewers for their consideration. Any comments not received within the requested time period will be considered by EPA in their revisions.

EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of beryllium that will appear on the Integrated Risk Information System (IRIS) database.
Background
Beryllium is a light alkaline earth metal used in metal alloys and in high-performance products in the metallurgical, aerospace, and nuclear industries. According to the Superfund database, beryllium is found in over 300 NPL sites. An IRIS Toxicological Review of Beryllium and Compounds was published in 1988 and reassessed in 1998.

This external review draft version only focuses on the cancer assessment and does not re-evaluate posted reference doses or reference concentrations.

History/Chronology

Nov 1987EPA completed the original beryllium and compounds assessment and posted this in the IRIS database.
Apr 1998Reassessment of oral reference dose and inhalation reference concentration released with cancer reassessment pending forthcoming studies.
May 2008EPA releases assessment that includes updated draft cancer assessment for an external peer review.

Next Steps

Following the External Peer Review, the final assessment will be published on the IRIS database.

Downloads/Related Links

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select “Environmental Protection Agency” and the key word “EPA- HQ-ORD-2008-0315” (for the docket ID).

Citation

U.S. EPA. IRIS Toxicological Review of Beryllium (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/009A.
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