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IRIS Toxicological Review and Summary Documents for Thallium and Compounds
Federal Register Notices
Contact
- Octavia Conerly
- by phone at: 202-566-1094
- by email at: conerly.octavia@epa.gov
- by email at: conerly.octavia@epa.gov
Notice
[4/8] Update: EPA has announced the External Peer Review Panel Workshop in an April 8, 2008 Federal Register notice.
EPA announces the release of the Toxicological Review of Thallium in the Feb 15, 2008 Federal Register notice. This draft assessment is provided for public viewing and comment. Public comments received on the Toxicological Review within 60 days after the release of the FRN will be provided to the external peer reviewers for their consideration. Any comments not received within the requested time period will be considered by EPA in their revisions. The date and location of the external peer review meeting will be provided in a separate announcement.
Background
Thallium exists in monovalent (Tl+1) and trivalent (Tl+3) states. Thallium is released to the environment through the combustion of fossil fuels, refinement of oil fractions, the smelting of ferrous and non-ferrous ores, and by some other industrial processes such as cement production and brick works. In the past, thallium was used as a depilatory agent and as a treatment for ringworm, venereal diseases, TB, and malaria. It was banned for use as a pesticide in the United States in 1972. Currently, thallium compounds are used in the semiconductor industry, the manufacture of optic lenses and low-melting glass, low-temperature thermometers, alloys, electronic devices, mercury lamps, fireworks, and imitation gems, and clinically as an imaging agent in the diagnosis of certain tumors.
History/Chronology
| 1987 | IRIS assessments of thallium acetate, carbonate, chloride, nitrate, selenite, and sulfate, and thallic oxide posted on the IRIS database (RfD only). |
| 1988 | RfDs for thallium compounds revised. |
| 1989 | RfD for thallic oxide withdrawn from the IRIS database. |
| 1990 | Carcinogenicity assessments for thallium compounds added to the IRIS database. |
| 1993 | RfD for thallium selenite withdrawn from the IRIS database. |
| Feb 2008 | EPA releases the draft document, IRIS Toxicological Review of Thallium, for public review and comment in a February 15, 2008 Federal Register notice. |
| Apr 2008 | EPA announces the external peer review panel workshop in an April 8, 2008 Federal Register notice. |
Next Steps
Following the External Peer Review, the final assessment will be published on the IRIS database.
Downloads/Related Links
- Toxicological Review of Thallium (External Review Draft) (PDF) (86 pp, 474 KB, about PDF)
- Charge to External Peer Reviewers (PDF) (3 pp, 21 KB, about PDF)
- Consolidated Comments from the External Peer Review (Final) (PDF) (76 pp, 257 KB, about PDF)
Related Link(s)
- Compilation of Reviewer Comments and Responses to Charge Questions (Reported By Midwest Research Institute) (PDF) (10 pp, 43 KB, about PDF)
- Volume 1: Range Finding (14-Day Study) (PDF) (55 pp, 29 MB, about PDF)
- Volume 2: Range Finding (90-Day Study) Part 1 (PDF) (299 pp, 57 MB, about PDF)
-
Volume 2: Range Finding Part 2 (Appendix IV) (PDF)
(255 pp, 150 MB,
about PDF)
Additional Information
Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select “Environmental Protection Agency” and the keyword “EPA-HQ-ORD-2008-0057” (for the docket ID) to comment on this report.
by phone at: 202-566-1094
by fax at: 202-566-1140
by email at: conerly.octavia@epa.gov
Susan Rieth
by phone at: 703-347-8582
by fax at: 703-347-8699
by email at: rieth.susan@epa.gov
Contact Information
Octavia Conerlyby phone at: 202-566-1094
by fax at: 202-566-1140
by email at: conerly.octavia@epa.gov
Susan Rieth
by phone at: 703-347-8582
by fax at: 703-347-8699
by email at: rieth.susan@epa.gov
Citation
U.S. EPA. IRIS Toxicological Review and Summary Documents for Thallium and Compounds. U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/001, 2008.
