Award Abstract #0634788
Homodyne Amplified Resonant Rayleigh Polarized Scattering (HARRPS)

NSF Org:	CHE Division of Chemistry
Initial Amendment Date:	July 24, 2006
Latest Amendment Date:	November 5, 2007
Award Number:	0634788
Award Instrument:	Standard Grant
Program Manager:	Zeev Rosenzweig CHE Division of Chemistry MPS Directorate for Mathematical & Physical Sciences
Start Date:	August 15, 2006
Expires:	March 31, 2008 (Estimated)
Awarded Amount to Date:	$150000
Investigator(s):	Xiaoliang Xie xie@chemistry.harvard.edu (Principal Investigator)
Sponsor:	Harvard University 1350 MASSACHUSETTS AVE Cambridge, MA 02138 617/495-5501
NSF Program(s):	ANALYTICAL SEPARATIONS & MEAS., STRUCTURE AND REACTIVITY
Field Application(s):
Program Reference Code(s):	OTHR, 9237, 0000
Program Element Code(s):	1974, 1960

ABSTRACT

In this Small Grant for Exploratory Research (SGER) funded by the Analytical and Surface Chemistry (ASC) and Experimental Physical Chemistry (EPC) programs of the Chemistry Division Prof. Xie of Harvard University and co-workers will develop a new analytical technique to detect single molecules in solution at room temperature. Prof. Xie and his students will measure resonant Rayleigh scattering of single molecules using a homodyne detection system with a controlled local field. Since spectra of resonant Rayleigh scattering are similar to absorption spectra they do offer spectroscopic identities for single molecules. Xie and his students will target single biomolecules during this exploratory study. If successful the new measurement technique will change the way single-molecule experiments are conducted on chemical and biological systems, and open up many new systems for single-molecule studies. This will have a profound impact on the fields of chemistry and biophysics.

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