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Award Abstract #0442151
A Generic Silica Sol-Gel Bio-Encapsulation for Sensor Development
| NSF Org: |
CHE
Division of Chemistry
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| Initial Amendment Date: |
September 9, 2004 |
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| Latest Amendment Date: |
December 22, 2006 |
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| Award Number: |
0442151 |
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| Award Instrument: |
Standard Grant |
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| Program Manager: |
Katharine J. Covert
CHE Division of Chemistry
MPS Directorate for Mathematical & Physical Sciences
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| Start Date: |
January 1, 2005 |
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| Expires: |
December 31, 2007 (Estimated) |
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| Awarded Amount to Date: |
$200000 |
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| Investigator(s): |
Wai Tak Yip ivan-yip@ou.edu (Principal Investigator)
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| Sponsor: |
University of Oklahoma Norman Campus
731 ELM AVENUE, ROOM 134
NORMAN, OK 73019 405/325-4757
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| NSF Program(s): |
APPROACHES TO COMBAT TERRORISM,
OFFICE OF MULTIDISCIPLINARY AC
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| Field Application(s): |
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| Program Reference Code(s): |
BIOT, 9237, 9183, 9150, 7276
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| Program Element Code(s): |
V596, 7276, 1253
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ABSTRACT
This project integrates vesiclar protein encapsulation, silica sol-gel synthesis, and electroporation into a novel silica sol-gel bio-encapsulation protocol. Contrary to direct entrapment where a protein is usually found immobilized on a silica surface displaying restricted mobility, this new protocol uses lipid vesicles to protect the protein from reactive silanol groups during silica sol-gel synthesis. The resultant protein-silica biocomposite material can be "activated" in a subsequent step where electroporation is used to destroy the vesicles and free the protein. The project goal is to develop a generic bio-encapsulation approach to enhance protein mobility by minimizing protein to silica surface attachment.
This award is supported jointly by the NSF and the Intelligence Community. The Approaches to Combat Terrorism Program in the Directorate for Mathematics and Physical Sciences supports new concepts in basic research and workforce development with the potential to contribute to national security.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
(Showing: 1 - 2 of 2).
Tami A. Martyn, Jason L. Moore, Ronald L. Halterman, Wai Tak Yip.
"Cucurbit[7]uril Induces Superior Probe Performance for Single-Molecule Detection,"
Journal of the American Chemical Society,
v.129,
2007,
p. 10338.
Ye Li and Wai Tak Yip.
"Liposomes as protective capsules for active silica sol-gel biocomposite synthesis,"
Journal of the American Chemical Society,
v.127,
2005,
p. 12756.
(Showing: 1 - 2 of 2).
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