Use of a Simple Pharmacokinetic Model to Characterize Exposure to Perchlorate
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- Matthew Lorber
- by phone at: 703-347-8535
- by email at: lorber.matthew@epa.gov
- by email at: lorber.matthew@epa.gov
The model was then used to study background exposures to perchlorate. A national sampling of perchlorate in urine showed a median concentration of 0.0035 mg/l, and this was used to back-calculate a dose of 0.000064 mg/kg/day. This finding was independently verified with the modeling structure of this study, as use of that back-calculated dose of 0.000064 mg/kg/day resulted in predictions of urine concentration with an average virtually identical at 0.0033 mg/l. An examination of literature data on the possible pathways of exposure suggests that the consumption of foods, rather than ingestion of water, dominates background exposures. Daily variation in urine concentration was studied with the model, and it was found that concentrations in the morning hours were lower than concentrations in the afternoon and evening hours, corresponding to the time when most exposure was assumed to occur.
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Use of a Simple Pharmacokinetic Model to Characterize Exposure..
Citation
LORBER, M. Use of a Simple Pharmacokinetic Model to Characterize Exposure to Perchlorate. Journal of Exposure Science and Environmental Epidemiology . Nature Publishing Group, London, Uk, , 1-14, (2008).