Risk Assessment Guidelines

EPA's Risk Assessment Guidelines were developed, based on recommendations from the National Academy of Science, to help guide EPA scientists in assessing the risks from chemicals or other agents in the environment. They also inform EPA decision makers and the general public about these procedures. The initial risk assessment guidelines related to cancer, mutagenic effects, developmental effects, exposure assessment, and chemical mixtures. Today EPA continues to develop new guidelines and also works to revise its original guidelines as experience and scientific knowledge improve.

Here is a list of the current Risk Assessment Guidelines:

• Guidelines for Carcinogen Risk Assessment
  2005 guidelines and 2005 supplementary guidance,
  Federal Register 70 (66) 17765-17817, 7 April 2005

• Guidelines for Chemical Mixtures Risk Assessment
  2000 supplementary guidance and 1986 guidelines,
  Federal Register 51 (185) 34014-34025, 24 September 1986

• Guidelines for Ecological Risk Assessment
  Federal Register 63 (93) 26846-26924, 14 May 1998

• Guidelines for Neurotoxicity Risk Assessment
  Federal Register 63 (93) 26926-26954, 14 May 1998

• Guidelines for Reproductive Toxicity Risk Assessment
  Federal Register 61 (212) 56274-56322, 31 October 1996

• Guidelines for Exposure Assessment
  Federal Register 57 (104) 22888-22938, 29 May 1992

• Guidelines for Developmental Toxicity Risk Assessment
  Federal Register 56 (234) 63798-63826, 5 December 1991

• Guidelines for Mutagenicity Risk Assessment
  Federal Register 51 (185) 34006-34012, 24 September 1986

Additional Information