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TCDD-Induced Insulin Resistance
EPA Grant Number: R827685E03Title: TCDD-Induced Insulin Resistance
Investigators: Kern, Philip A. , Kennedy, Richard H.
Institution: University of Arkansas for Medical Sciences
EPA Project Officer: Winner, Darrell
Project Period: August 1, 1999 through July 31, 2001
RFA: EPSCoR (Experimental Program to Stimulate Competitive Research) (1999)
Research Category: EPSCoR (The Experimental Program to Stimulate Competitive Research)
Description:
Objective:The objective of this
research project was to examine the role of environmental dioxin exposure in
the development
of insulin resistance, a prediabetic state in which normal blood glucose levels
are maintained by high circulating levels of insulin. The most toxic of the
dioxin compounds is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD was the
primary dioxin component of "Agent Orange" and has been found at
numerous toxic waste sites, including the Vertac Superfund site in Jacksonville,
AR. Thus, the problem is not limited to Vietnam veterans; many Americans have
been exposed to TCDD. The objectives of this project were to document further
this pathology in humans, and to use an animal model to determine if the toxic
mechanism includes effects on tumor necrosis factor (TNF)-
, glucose transporters,
lipase activities, or peroxisome proliferator-activated receptor-
.
Publications have been submitted on this project: View all 3 publications for this project
Journal Articles:Journal Articles have been submitted on this project: View all 3 journal articles for this project
Supplemental Keywords:health effects, mammalian, sensitive populations, 2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD, insulin, Experimental Program to Stimulate Competitive Research, EPSCoR, Science and Engineering Environmental Research, SEER, dioxin, Agent Orange, toxic, Arkansas, AR, Vertac/Hercules Superfund Site. , ENVIRONMENTAL MANAGEMENT, Geographic Area, Scientific Discipline, Health, Risk Assessment, Risk Assessments, Health Risk Assessment, Environmental Chemistry, State, exposure assessment, toxic environmental contaminants, dioxin exposure, insulin resistance, human health risk, comparative metabolism, tumor necrosis factor, dioxin, Agent Orange, TCDD, assessment technology, human exposure
Progress and Final Reports:
Final Report