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Improved Reproductive Risk Assessment by Elucidation of Comparative Metabolism

EPA Grant Number: R827685E02
Title: Improved Reproductive Risk Assessment by Elucidation of Comparative Metabolism
Investigators: Gandy, Jay
Institution: University of Arkansas for Medical Sciences
EPA Project Officer: Winner, Darrell
Project Period: August 1, 1999 through July 31, 2001
RFA: EPSCoR (Experimental Program to Stimulate Competitive Research) (1999)
Research Category: EPSCoR (The Experimental Program to Stimulate Competitive Research)

Description:

Objective:

The objective of this research project was to develop in vitro systems expressing isoforms of rodent drug metabolizing enzymes that are expressed in reproductive tissues and compare them with corresponding human isoforms, which currently are available commercially. Knowledge of species-comparative differences in the metabolism of drugs and endocrine disrupting chemicals will allow animal study data to provide a better assessment of human risk.

Publications and Presentations:

Publications have been submitted on this project: View all 1 publications for this project

Journal Articles:

Journal Articles have been submitted on this project: View all 1 journal articles for this project

Supplemental Keywords:

species comparison, endocrine disruptors, reproductive tissue, reproductive risk assessment, reproduction, metabolism, Experimental Program to Stimulate Competitive Research, EPSCoR, Science and Engineering Environmental Research, SEER. , ENVIRONMENTAL MANAGEMENT, Geographic Area, Scientific Discipline, Health, RFA, PHYSICAL ASPECTS, Endocrine Disruptors - Environmental Exposure & Risk, Risk Assessment, Risk Assessments, Health Risk Assessment, Physical Processes, endocrine disruptors, Environmental Chemistry, State, Endocrine Disruptors - Human Health, exposure assessment, endocrine disruptor screening program, reproductive risk management, metabolizing enzymes, endocrine disrupting chemicals, insulin resistance, human health risk, comparative metabolism, exposure, assessment technology, human exposure, Arkansas, human reproductive health

Progress and Final Reports:
Final Report

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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