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Organophosphate Pesticides (OP) Cumulative Assessment - 2006 Update
Docket Information
- See Docket EPA-HQ-OPP-2006-0618 to view related to EPA's review of this pesticide.
- Visit Regulations.gov for information about other pesticide reregistration chemicals.
Federal Register Notices
- Organophosphate Cumulative Risk Assessment; Notice of Availability [August 2, 2006], comment period closed on October 2, 2006
OP Cumulative Assessment - 2006 Update
- Transmittal Memo (PDF) (1 pp, 24 KB, About PDF)
- Complete Zipped Document (without Excel appendices, below) (zipped, 19 MB)
Divided Document
- Cumulative Assessment (190 pp, 7.7 MB, About PDF)
Appendices Referenced in OP Cumulative Assessment
- Appendices II.A1, II.B.1 and II.B.2. (PDF) (131 pp, 5.3 MB, About PDF)
- Mitigation Summary
- Benchmark dose calculations for selected OPs from repeated dosing comparative ChE studies
- RBC and brain ChE activity in dams and fetuses from comparative ChE studies following gestational exposure
- Appendix II.B.3. Cholinesterase Data used in OP Cumulative Risk Assessment to Derive Relative Potency Factors (RPFs) and Points of Departure (PoDs) (zipped, 338 KB)
- Appendix II.B.4. Spreadsheet with Data from Repeated Dosing Comparative Cholinesterase Studies (Juvenile and Adult Rats) (Excel, 148 KB)
- Appendix II.C.1. The Sources of Residue Inputs for the Assessment of the Cumulative Dietary Exposure to Organophosphorus Pesticides on Foods (Excel, 113 KB)
- Appendix II.C.2. Summary of Residue Analyses of Organophosphorus Pesticides on Foods (1994-2004) (Excel, 266 KB)
- Appendices II.C.3 and II.C.4 (PDF) (139 pp, 5.6 MB, About PDF)
- A summary of FDA Total Diet Study Analyses for Organophosphorus Pesticides in Meats (1991-2001)
- Permissible Crop Translations for Pesticide Monitoring Data Table
- Appendix II.C.5. Processing Factors Used in Estimating Residues of OP Pesticides in Food Commodities (Excel, 434 KB)
- Appendix II.C.6. Translation of Residue Source Data to CSFII Food Forms (Excel, 207 KB)
- Appendix II.C.7. Summary of Residue Distribution Inputs to DEEM-FCID for Cumulative OP Exposure Assessment (Excel, 196 KB)
- Appendix II.C.8. Analysis of Chemicals and Foods in the Upper Portion of OP Cumulative Exposure Distribution for Children 3-5 Years Old (Excel, 436 KB)
- Appendix II.C.9. Co-Occurrence of Organophosphorus Pesticides on PDP Samples, 1994-2004 (25 KB)
- Appendix II.D.1, II.E.1, and II.E.2 (PDF) (139 pp, 5.6 MB, About PDF)
- Supplemental Distributions of Exposure Data Incorporated in the Residential Assessment
- OP Cumulative Exposure in Drinking Water: The Effects of Water Chlorination on Organophosphate (OP) Pesticides (Phase I)
- OP Cumulative Exposure in Drinking Water: The Effects of Water Chlorination on Three Specific Prganophosphate (OP) Pesticides (Phase II)
- Appendix II.E.3. Water Outputs – Region A (zipped, 7.2 MB)
- Appendix II.E.4. Water Outputs – Region B (zipped, 17.4 MB)
- Appendix II.E.5. Water Outputs – Region C (zipped, 17.6 KB)
- Appendix II.E.6. Water Outputs – Region D (zipped, 3.3 MB)
- Appendix II.E.7. Water Outputs – Region E (zipped, 9.3 MB)
- Appendix II.E.8. Water Outputs – Region F (zipped, 10.9 MB)
- Appendix II.E.9. Water Outputs – Region G (zipped, 7.3 MB)
- Appendix II.G.1, II.G.2, II.G.3 (PDF) (139 pp, 5.6 MB, About PDF)
- Sensitivity Analysis: Cancellation of Azinphos-Methyl Group 3 Uses
- Characterization of Potential Oxon Formation and Exposure in Drinking Water
- Characterization of OP Cumulative Residues in Drinking Water: Region A
- Appendix II.G.4-1 Spreadsheet with Data from Acute Dosing Comparative Cholinesterase Studies (Juvenile and Adult Rats) for Sensitivity Analysis (Acute Sensitivity) (Excel, 63 KB)
- Appendix III: Multipathway Graphs for the OP Cumulative Risk
Assessment, 2006 Update (PDF) (66 pp, 4.2 MB, About PDF)
- Region A
- Region C 1x
- REgion C 10x
- Region C 100x
- Region G
These documents are in PDF, Excel or Zip format. If you do not have Microsoft Excel, you may download the free Excel viewer. 
Larger files have been zipped. To unzip these files, you will need unzipping software such as StuffIt or Winzip.