Project Number: 1275-22000-252-02
Project Type: Specific Cooperative Agreement

Start Date: Dec 01, 2003
End Date: Nov 30, 2008

Objective:
Develop new strategies and expression systems in plants using plant viruses as delivery vehicles and transgenic plants for expression of foreign proteins. Develop plant virus-based vectors for presentation of antigenic determinants for production of biomedicals in plants. Develop new technologies and products for prevention, treatment, and control of various diseases in humans and animals. Evaluate efficacy of biomedicals in humans and animals.

Approach:
Develop improved plant virus-based vectors and expression strategies for fruit and vegetable crops, including a plant rhabdovirus. Develop in plants and test new technologies and products to control diseases of human and animals, including anti-rabies plantibodies, cancer-specific monoclonal antibodies that target colorectal and breast cancers, a multivalent pediatric vaccine, a colorectal cancer vaccine, and plant-derived oral vaccines for anthrax and smallpox. BL1/BL2p 03/01/2006.