Carlos A. Murillo
CHE Division of Chemistry
MPS Directorate for Mathematical & Physical Sciences
Start Date:
August 15, 2006
Expires:
July 31, 2009 (Estimated)
Awarded Amount to Date:
$516500
Investigator(s):
Franklin Schultz SCHULTZ@CHEM.IUPUI.EDU (Principal Investigator)
Eric Long (Co-Principal Investigator) Martin O'Donnell (Co-Principal Investigator) Robert Minto (Co-Principal Investigator) Zhong-Yin Zhang (Co-Principal Investigator)
Sponsor:
Indiana University
P O Box 1847
Bloomington, IN 47402 812/855-0516
NSF Program(s):
MAJOR RESEARCH INSTRUMENTATION
Field Application(s):
Program Reference Code(s):
OTHR, 9184, 9161, 9141, 0000
Program Element Code(s):
1189
ABSTRACT
With support from the Major Research Instrumentation (MRI) Acquisition Program, the Department of Chemistry and Chemical Biology at Indiana University-Purdue University at Indianapolis (IUPUI) will acquire a 500 MHz NMR spectrometer. The spectrometer will be used in various research investigations involving natural and non-natural products, advanced polymers for biomedical applications, electron transfer and spin-crossover reactions, protein tyrosine phosphatases, metallopeptides that bind to DNA, synthesis of peptidomimetics, stereoselective boron alkylation studies, structural characterization of sphingolipids, and biosynthetic pathways to polyacetylenes.
Nuclear Magnetic Resonance (NMR) Spectroscopy is the most widely used tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances and to provide information on the arrangement and connectivity of atoms in molecules. Dynamical information is obtained providing insight on the motions of molecules. This award will provide essential analytical capabilities to faculty and students at (IUPUI). Creation and implementation of a NMR certification program for student users is planned to enhance the educational value of the new instrument.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
(Showing: 1 - 5 of 5).
Oh, K.; Kim, H.; Cardelli, F.; Bwititi, T.; Martynow, A. M..
"Synthesis of Cyclic Cyclic Thioethers through Tandem C(sp3)-S and C(sp2)-S Bond Formations from alpha,beta-Dichloro Vinyl Ketones,"
J. Org. Chem.,
v.73,
2008,
p. 2432.
Oh, K.; Ryu, J..
"Chiral Tertiary Amine N-Oxides in Asymmetric Epoxidation of alpha,beta-Unsaturated Ketones,"
Tetrahedron Lett.,
v.49,
2008,
p. 1935.
Ramamoorthy, V; Cahoon, EB; Li, J; Thokala, M; Minto, RE; Shah, DM.
"Glucosylceramide synthase is essential for alfalfa defensin-mediated growth inhibition but not for pathogenicity of Fusarium graminearum,"
MOLECULAR MICROBIOLOGY,
v.66,
2007,
p. 771
- 786.
Xie, D., Zhao, J., Yang, Y., Park, J.-G., Chu T.M., Zhang, J.T..
"Preparation and evaluation of a high-strength biocompatible glass-ionomer cement for improved dental restoratives,"
Biomed. Mater.,
v.3,
2008,
p. 1.
Yu, X.; Sun, J.-P.; He, Y.; Guo, X.-L.; Liu, S.; Zhou, B.; Hudmon, A.; Zhang, Z.-Y..
"Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases,"
Proc. Natl. Acad. Sci., USA,
v.104,
2007,
p. 19767.
(Showing: 1 - 5 of 5).
Please report errors in award information by writing to: awardsearch@nsf.gov.
