Award Abstract #0619184
MRI: Acquisition of an Atomic Force Microscope for Biological Materials Research and Training
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NSF Org: |
CBET
Division of Chemical, Bioengineering, Environmental, and Transport Systems
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Initial Amendment Date: |
July 28, 2006 |
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Latest Amendment Date: |
July 28, 2006 |
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Award Number: |
0619184 |
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Award Instrument: |
Standard Grant |
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Program Manager: |
Leon Esterowitz
CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems
ENG Directorate for Engineering
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Start Date: |
November 1, 2006 |
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Expires: |
October 31, 2009 (Estimated) |
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Awarded Amount to Date: |
$193502 |
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Investigator(s): |
Rebecca Willits willitsr@slu.edu (Principal Investigator)
Robert Martin (Co-Principal Investigator) Shelley Minteer (Co-Principal Investigator) Susan Spencer (Co-Principal Investigator) Cheryl Miller (Co-Principal Investigator)
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Sponsor: |
Saint Louis University
221 N. Grand Blvd.
St. Louis, MO 63103 314/977-3925
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NSF Program(s): |
MAJOR RESEARCH INSTRUMENTATION
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Field Application(s): |
0000099 Other Applications NEC
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Program Reference Code(s): |
OTHR,004E,0000
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Program Element Code(s): |
1189
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ABSTRACT
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0619184
Willits
This proposal from an interdisciplinary group of faculty in the Departments of Biomedical Engineering, Chemistry, and Biology at Saint Louis University (SLU), a PhD-granting institution, requests funding for an atomic force microscope (AFM) with an inverted microscope capable of epifluorescence and brightfield, which will be used both for research and to train undergraduate and graduate students. The projects that would use the AFM include research to 1) characterize the properties of 3D synthethic scaffolds that enhance and direct nerve extension; 2) identify and characterize the effect of electric fields on nerve growth; 3) develop microchip-based analysis systems that enable cell culture and have the ability to analyze neurochemicals released from cells; 4) use tissue engineering to study chronic disease, illness, and injury; 5) examine properties of pores in materials designed for immobilization of enzymes for biofuel cells; 6) examine binding between proteins that mediate cell adhesion; and 7) develop polymeric biomaterial coatings and orthopaedic constructs for fracture healing and vertebral fusion.
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