Award Abstract #0614785
Acquisition of an Upgrade for a 500 MHz NMR Spectrometer

NSF Org:	CHE Division of Chemistry
Initial Amendment Date:	August 8, 2006
Latest Amendment Date:	August 8, 2006
Award Number:	0614785
Award Instrument:	Standard Grant
Program Manager:	Carlos A. Murillo CHE Division of Chemistry MPS Directorate for Mathematical & Physical Sciences
Start Date:	August 15, 2006
Expires:	July 31, 2009 (Estimated)
Awarded Amount to Date:	$383765
Investigator(s):	Fraser Fleming flemingf@duq.edu (Principal Investigator) Partha Basu (Co-Principal Investigator) Mihaela-Rita Mihailescu (Co-Principal Investigator) Tomislav Pintauer (Co-Principal Investigator)
Sponsor:	Duquesne University Room 424 Rangos Building Pittsburgh, PA 15282 412/396-6326
NSF Program(s):	MAJOR RESEARCH INSTRUMENTATION
Field Application(s):
Program Reference Code(s):	OTHR, 9184, 9141, 0000
Program Element Code(s):	1189

ABSTRACT

With support from the Major Research Instrumentation (MRI) Acquisition Program, the Department of Chemistry and Biochemistry at Duquesne University will upgrade a 500 MHz NMR spectrometer. The upgraded spectrometer will foster conceptually new research on nitrile anions, transition metal catalysis, anti-tumor agents, emerging drug targets, reactive molybdenum intermediates and elucidate protein-nucleic acid interactions.

Nuclear Magnetic Resonance (NMR) Spectroscopy is the most widely used tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances and to provide information on the arrangement and connectivity of atoms in molecules. Dynamical information is obtained providing insight on the motions of molecules. This award will provide essential analytical capabilities to faculty and students at Duquesne University and be used occasionally by several other smaller institutions that have collaborations with Duquesne.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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Eckenhoff, WT; Garrity, ST; Pintauer, T.  "Highly efficient copper-mediated atom-transfer radical addition (ATRA) in the presence of reducing agent,"  EUROPEAN JOURNAL OF INORGANIC CHEMISTRY,  2008,  p. 563 - 571.  

Eckenhoff, WT; Pintauer, T.  "Atom transfer radical addition in the presence of catalytic amounts of copper(I/II) complexes with tris(2-pyridylmethyl)amine,"  INORGANIC CHEMISTRY,  v.46,  2007,  p. 5844 - 5846.  

Fleming, FF; Gudipati, S; Vu, VA; Mycka, RJ; Knochel, P.  "Grignard reagents: Alkoxide-directed iodine-magnesium exchange at Sp(3) Centers,"  ORGANIC LETTERS,  v.9,  2007,  p. 4507 - 4509.  

Fleming, FF; Liu, W; Ghosh, S; Steward, OW.  "Metalated nitriles: Internal 1,2-asymmetric induction,"  JOURNAL OF ORGANIC CHEMISTRY,  v.73,  2008,  p. 2803 - 2810.  

Fleming, FF; Wei, YJ; Liu, W; Zhang, ZY.  "Metalated nitriles: Cation-controlled cyclizations,"  ORGANIC LETTERS,  v.9,  2007,  p. 2733 - 2736.  

Menon, L; Mihailescu, MR.  "Interactions of the G quartet forming semaphorin 3F RNA with the RGG box domain of the fragile X protein family,"  NUCLEIC ACIDS RESEARCH,  v.35,  2007,  p. 5379 - 5392.  

Ricardo, C; Pintauer, T.  "Synthesis, characterization, and the role of counterion in cyclopropanation of styrene catalyzed by [Cu-I(2,2'-bpy)(pi-CH2=CHC6H5)][A] (A = ClO4-, PF6- and CF3SO3-) complexes,"  JOURNAL OF ORGANOMETALLIC CHEMISTRY,  v.692,  2007,  p. 5165 - 5172.  

Sengar, R.S.; Miller, J.; Basu, P..  "Design, Syntheses, and Characterization of Dioxo-molybdenum(VI) Complexes With Thiolate Ligands: Effects of Intraligand NH???S Hydrogen Bonding,"  Dalton Transactions,  2008,  p. 2569.


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