Award Abstract #0521648
Acqusition of an LC/MS to Facilitate Collaboration and Faculty-Undergraduate Research at the University of Portland, Lewis & Clark College and Portland Veterans Medical Center

NSF Org:	CHE Division of Chemistry
Initial Amendment Date:	July 27, 2005
Latest Amendment Date:	July 27, 2005
Award Number:	0521648
Award Instrument:	Standard Grant
Program Manager:	Carlos A. Murillo CHE Division of Chemistry MPS Directorate for Mathematical & Physical Sciences
Start Date:	September 15, 2005
Expires:	August 31, 2008 (Estimated)
Awarded Amount to Date:	$182299
Investigator(s):	Angela Hoffman hoffman@up.edu (Principal Investigator) Kevin Cantrell (Co-Principal Investigator)
Sponsor:	University of Portland 5000 N Willamette Blvd Portland, OR 97203 503/943-7395
NSF Program(s):	MAJOR RESEARCH INSTRUMENTATION
Field Application(s):
Program Reference Code(s):	EGCH, BIOT, 9198, 9184, 9141
Program Element Code(s):	1189

ABSTRACT

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry and Physics at the University of Portland will acquire a liquid chromatograph/mass spectrometer (LC/MS). This equipment will be shared with researchers from Lewis & Clark College and Portland Veterans Medical Center. It will enhance research in a number of areas including a) natural product research, b) chemical communications between plants and their environment, c) regulation of biochemical pathways involved in synthesis of taxanes, carotenoids and sterols, d) elucidation of the mechanisms and kinetics of microbially mediated environmental processes, e) characterization of terpenoids and aromatic compounds, f) studies of hydrolysis of molybdenum metallocenes, and g) the screening and optimization of leads for antimalarial drugs.

Liquid chromatography with mass spectrometric detection (LC/MS) is an extremely powerful technique used for the separation and analysis of complex mixtures. This instrument will substantially strengthen scientific research at the University of Portland, a primarily undergraduate institution. These studies will have a solid impact in the area of biochemistry, environmental chemistry and medicinal chemistry.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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A. Hoffman, S. Mayer, G. Strobel, W. Hess, G. Sovocool, A. Grange, J. Harper, A. Arif, A. Grant.  "Purification, identification and activity of phomodione, a furandione from an endophytic Phoma species.,"  Phytochemistry,  v.69,  2008,  p. 1049.


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