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Award Abstract #0521637
MRI: Instrument Development: An Integrated Optical Tweezers/Micro-PIV System to Investigate Cell Biomechanics
| NSF Org: |
CBET
Division of Chemical, Bioengineering, Environmental, and Transport Systems
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| Initial Amendment Date: |
August 29, 2005 |
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| Latest Amendment Date: |
August 29, 2005 |
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| Award Number: |
0521637 |
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| Award Instrument: |
Standard Grant |
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| Program Manager: |
Leon Esterowitz
CBET Division of Chemical, Bioengineering, Environmental, and Transport Systems
ENG Directorate for Engineering
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| Start Date: |
September 1, 2005 |
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| Expires: |
August 31, 2007 (Estimated) |
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| Awarded Amount to Date: |
$214226 |
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| Investigator(s): |
Derek Tretheway derekt@cecs.pdx.edu (Principal Investigator)
Sean Kohles (Co-Principal Investigator)
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| Sponsor: |
Portland State University
2121 SW Fourth Ave.
portland, OR 97207 503/725-3423
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| NSF Program(s): |
MAJOR RESEARCH INSTRUMENTATION
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| Field Application(s): |
0000099 Other Applications NEC
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| Program Reference Code(s): |
OTHR, 5345, 0000
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| Program Element Code(s): |
1189
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ABSTRACT
Tretheway 0521637
The objective is to develop a novel instrument to explore the effects of fluid induced mechanical stresses on musculoskeletal cell activity. The proposed instrument combines the individual capabilities of micron-resolution particle image velocimetry (u-PIV) and optical tweezers. The proposed instrument will uniquely subject the same individual cell to a sequence of mechanical perturbations that cover a wide range of static and dynamic mechanical stress conditions. The sequence can be conducted quickly and will not require changing equipment, altering the culture media, or examining a completely new cell. The combined optical tweezers/u-PIV technique is unique in that it is a single cell approach requiring no mechanical restraints and that it extends the range of applicable fluid induced stresses to include extensional stresses.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
(Showing: 1 - 1 of 1).
SS Kohles, CG Wilson, and L.J. Bonassar.
"A Mechanical Composite Sphere Analysis of Engineered Cartilage Dynamics,"
ASME Journal of Biomechanical Engineering,
v.129,
2007,
p. 473.
(Showing: 1 - 1 of 1).
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