Award Abstract #0521216
Development of Advanced Structural Techniques for Gas-Phase Ions

NSF Org:	CHE Division of Chemistry
Initial Amendment Date:	July 26, 2005
Latest Amendment Date:	July 26, 2005
Award Number:	0521216
Award Instrument:	Standard Grant
Program Manager:	Robert L. Kuczkowski CHE Division of Chemistry MPS Directorate for Mathematical & Physical Sciences
Start Date:	October 1, 2005
Expires:	September 30, 2008 (Estimated)
Awarded Amount to Date:	$966485
Investigator(s):	David Russell russell@mail.chem.tamu.edu (Principal Investigator)
Sponsor:	Texas Agricultural Experiment Station 2147 TAMU COLLEGE STATION, TX 77845 979/845-4761
NSF Program(s):	MAJOR RESEARCH INSTRUMENTATION
Field Application(s):
Program Reference Code(s):	BIOT, 9184
Program Element Code(s):	1189

ABSTRACT

With support from the Major Research Instrumentation (MRI) Program, David Russell in the Department of Chemistry at Texas A&M University will develop a novel hybrid linear ion trap-ion mobility time of flight mass spectrometer (LIT-IM-MS) for structural characterization of gas-phase ions, including smallmolecules, macromolecules, clusters and nanoparticles. The LIT-IM-MS instrument will combine LIT technology, a periodic focusing ion-guide mobility drift cell, high-resolution orthogonal-TOFMS and multi-anode, micro-array ion detection, which can be used for rapid (microsec to millisec) post-ionization separation and mass analysis of ions formed by electrospray ionization or matrix-assisted laser desorption ionization, as well as small molecule ion sources. In adition, IM-MS structural studies can be performed on products of ion-molecule and ion-ion reactions, solvated species, ion clusters which are weakly bound, and species which are weakly interacting.

Although the primary focus of this project is instrument development, it will provide novel interdisciplinary training opportunities for postdoctoral fellows, graduate and undergraduate students in modern, cutting-edge mass spectrometry techniques and allied research areas. The research builds upon existing collaborations between scientists at Texas A&M University, Ionwerks, Inc. in Houston, and scientists at AB/MDS-Sciex in Toronto.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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Becker, C.; Tao, L.; Huang, Y.; Russell, D. H..  "Evaluating Gas Phase Structure: Coupled H/D Exchange-Ion Mobility Mass Spectrometry,"  Proceedings of the 55th Annual ASMS Conference on Mass Spectrometry and Allied Topics,  2007, 

Fernandez-Lima, F. A.; Becker, C.; Sun, W.; Gillig, K. J.; Chaer-Nascimento, M.; Russell, D. H..  "Pushing LDI-IM-oTOF interface to its limits: Theoretical and Experimental ionic cluster studies using selective collisional-energy transfer,"  Proceedings of the 55th Annual ASMS Conference on Mass Spectrometry and Allied Topics,  2007, 

Gillig, K. J.; May, J. C.; Blase, R. C.; Russell, D. H.  "Characterization of Ion Transmission Properties of Periodic Focusing and Uniform Field Drift Cells,"  Proceedings of the 55th Annual ASMS Conference on Mass Spectrometry and Allied Topics,  2007, 

May, J. C.; Gillig, K. J.; Blase, R. C.; Russell, D. H..  "Structural Studies of Small Molecule Radical Cations using a Variable Temperature Ion Mobility Apparatus,"  Proceedings of the 55th Annual ASMS Conference on Mass Spectrometry and Allied Topics,  2007, 

May, J. C.; McLean, J. A.; Russell, D. H..  "Development of a Hybrid Quadrupole-Linear Ion Trap-Ion Mobility-TOFMS for Structural Mass Spectrometry,"  Proceedings of the 54th Annual ASMS Conference on Mass Spectrometry and Allied Topics,  2006, 

Russell, D. H..  "New Concepts for Ion Mobility-Mass Spectrometry (IM-MS) Instruments,"  Proceedings of the 55th Annual ASMS Conference on Mass Spectrometry and Allied Topics,  2007, 

Tao, L.; McLean, J. R.; McLean, J. A.; Russell, D. H..  "A Collision Cross-Section Database of Singly-Charged Peptide Ions,"  J. Amer. Soc. Mass Spectrom,  v.18,  2007,  p. 1232.


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