Award Abstract #0521191
MRI: Acquisition of an NMR Spectrometer and Upgrade of an Existing NMR Spectrometer

NSF Org:	CHE Division of Chemistry
Initial Amendment Date:	July 13, 2005
Latest Amendment Date:	July 18, 2007
Award Number:	0521191
Award Instrument:	Standard Grant
Program Manager:	Carlos A. Murillo CHE Division of Chemistry MPS Directorate for Mathematical & Physical Sciences
Start Date:	August 1, 2005
Expires:	July 31, 2008 (Estimated)
Awarded Amount to Date:	$597752
Investigator(s):	Vincent Catalano vjc@unr.edu (Principal Investigator) Kent Ervin (Former Principal Investigator) Thomas Bell (Co-Principal Investigator) Benjamin King (Co-Principal Investigator)
Sponsor:	University of Nevada Reno 1664 North Virginia Street Reno, NV 89557 775/784-4040
NSF Program(s):	MAJOR RESEARCH INSTRUMENTATION
Field Application(s):
Program Reference Code(s):	BIOT, 9184, 9150, 7237
Program Element Code(s):	1189

ABSTRACT

With support from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at the University of Nevada in Reno will acquire a 400 MHz nuclear magnetic resonance (NMR) Spectrometer and upgrade an existing 500 MHz multinuclear NMR. This equipment will enable researchers to carry out studies on a) the design and synthesis of complex organic molecules; b) the synthesis, characterization, binding and luminescent properties of metallocryptands; c) the synthesis, structure and reactivity of organometallic complexes with emphasis on those applicable to aqueous/biphasic catalysis; d) the designed synthesis of one-dimensional benzenoid nanostructures; e) the stereochemistry of bilirubin and its carboxylate anions in organic and aqueous media by heteronuclear NMR; and f) the behavior of transition and main group metals in biological systems.

Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic chemistry, nanoscience and biochemistry.

PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH

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Boiadjiev, S. E.; Conley, B. A.; Brower, J. O. McDonagh, A. F.; Lightner, D. A..  "Synthesis and Hepatic Matabolism of Xanthobilirubinic Acid Regioisomers.,"  Monatsh. Chem.,  v.137,  2006,  p. 1463.

Boiadjiev, S. E.; Woydziak, Z. R.; McDonagh, A. F.; Lightner, D. A..  "Synthesis, Properties and Hapatic Metabolism of Strongly Fluorescent Fluorodipyrrinones,"  Tetrahedron,  v.62,  2006,  p. 7043.

C.A. Mebi, R.P. Nair, B.J. Frost.  "pH dependent selective transfer hydrogenation of a,b-unsaturated carbonyls in aqueous media utilizing half-sandwich ruthenium (II) complexes,"  Organometallics,  v.26,  2007,  p. 429.

G.W. Wong, J.L. Harkreader, C.A. Mebi, B.J. Frost.  "Synthesis and coordination chemistry of a novel chiral bidentate phosphine, 6-(diphenylphosphino)-1,3,5-triaza-7-phosphaadamantane (PTA-PPh2),"  Inorg. Chem.,  v.2006,  45,  p. 6748.

Hilton, C. L.; Jamison, C. R.; King, B. T..  "Uncatalyzed Zirconium-Mediated Biphenylation of o-Dihalobenzenes to Form Triphenylenes,"  J. Am. Chem. Soc.,  v.126,  2006,  p. 1284.

Hilton, C. L.; King, B. T..  "Four Homologous Zirconium 2,2′-Biphenyldiyls: Synthesis, Structure, and Reactivity,"  Organometallics,  v.25,  2006,  p. 4059.

Huang, X.; Zhang, L..  "Two-Step Formal [3+2] Cycloaddition of Enones/Enals and Allenyl MOM Ether: Gold-Catalyzed Highly Diastereoselective Synthesis of Cyclopentanone Enol Ether Containing an All-Carbon Quaternary Center,"  J. Am. Chem. Soc.,  v.129,  2007,  p. 6398.

King, B. T.; Kroulík, J; Robertson, C. R.; Rempala, P.; Hilton, C. L.; Korinek, J. D.; Gortari, L. M..  "Controlling the Scholl Reaction,"  J. Org. Chem.,  v.72,  2007,  p. 2279.

Rempala, P. S.; Kroulík, J.; King, B. T..  "Investigation of the Mechanism of the Intramolecular Scholl Reaction of Contiguous Phenyl Benzenes,"  J. Org. Chem.,  v.71,  2006,  p. 5067.

Salzameda, N. T.; Huggins, M. T.; Lightner, D. A..  "Carboxylic Acid to Amide Hydrogen Bonding. Oxo-Semirubins.,"  Tetrahedron,  v.62,  2006,  p. 7043.

Salzameda, N. T.; Huggins, M. T.; Lightner, D. A..  "Novel N(23)-C(10)-linked Linear Tetrapyrroles.,"  Tetrahedron,  v.62,  2006,  p. 9827.

Salzameda, N. T.; Lightner, D. A..  "Novel alpha-Keto Acid Intermolecular Hydrogen Bonding. Supramolecular Ribbons and Stacking in alpha-Pyrrole Glyoxaylic Acids.,"  Monatsh. Chem.,  v.137,  2006,  p. 1453.

Wang, S.; Zhang, L..  "A Gold-Catalyzed Unique Cycloisomerizationof 1,5-Enynes: Efficient Formation of 1-Carboxycyclohexa-1,4-dienes and Carboxyarenes,"  J. Am. Chem. Soc.,  v.128,  2006,  p. 14274.

Wang, S.; Zhang, L..  "Gold-Catalyzed Efficient Formation of Alkenyl Enol Esters/Carbonates from Trimethylsilylmethyl-Substituted Propargyl Esters/Carbonates,"  Org. Lett.,  v.8,  2006,  p. 4585.

Wang, S.; Zhang, L..  "A Highly Efficient Preparative Method of α-Ylidene-β-Diketones via AuIII-Catalyzed Acyl Migration of Propargylic Esters,"  J. Am. Chem. Soc.,  v.128,  2006,  p. 8414.

Yu, M.; Li, G.; Wang, S.; Zhang, L..  "Gold-Catalyzed Efficient Formation of , β-Unsaturated Ketones from Propargylic Acetates,"  Adv. Synth & Catal.,  v.349,  2007,  p. 871.

Zhang, L..  "Tandem Au-catalyzed 3,3-Rearrangement-[2+2] Cycloadditions of Propargylic Esters: Expeditious Access to Highly Functionalized 2,3-Indoline-fused Cyclobutanes,"  J. Am. Chem. Soc.,  v.127,  2005,  p. 16804.

Zhang, L.; Wang, S..  "Efficient Synthesis of Cyclopentenones from Enynyl Acetates via Tandem Au(I)-Catalyzed 3,3-Rearrangement and the Nazarov Reaction,"  J. Am. Chem. Soc.,  v.128,  2006,  p. 1442.


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