Middlebury College
9 OLD CHAPEL ROAD
MIDDLEBURY, VT 05753 802/443-5000
NSF Program(s):
MAJOR RESEARCH INSTRUMENTATION
Field Application(s):
Program Reference Code(s):
OTHR,9150,9141,0000
Program Element Code(s):
1189
ABSTRACT
With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry and Biochemistry at Middlebury College will acquire a liquid chromatograph ion trap tandem mass spectrometer (LC/MS). This equipment will enhance research in a number of areas including a) studies on radical reactions of transition metal-polyene complexes; b) methods for carrying out allylation reactions with allyl palladium complexes with high enantioselectivity; c) studying the mechanism of action of anti-cancer compounds closely related to the commonly prescribed drug, cisplatin; and d) studies of the Maillard reaction.
Liquid chromatography with mass spectrometric detection (LC/MS) is an extremely powerful technique used for the separation and analysis of complex mixtures. This instrument will substantially strengthen scientific research at Middlebury College, a primarily undergraduate institution. These studies will have a solid impact in the area of synthetic organic chemistry and medicinal chemistry.
PUBLICATIONS PRODUCED AS A RESULT OF THIS RESEARCH
(Showing: 1 - 4 of 4).
Byers, JH; Sontum, SF; Dimitrova, TS; Huque, S; Zegarelli, BM; Zhang, Y; Jasinski, JP; Butcher, RJ.
"Generation and trapping of radicals derived from cyclobutadieneiron tricarbonyl,"
ORGANOMETALLICS,
v.25,
2006,
p. 3787
- 3790.
Choi, S.; Vastag, L.; Leung, C. H.; Beard, A. M., Knowles, D. E., Larrabee, J. A. 2006, 45, 10108-10114..
""Kinetics and Mechanism of Oxidation of Guanosine Derivatives by Platinum(IV) Complexes","
Inorganic Chemistry,
v.45,
2006,
p. 10108.
Choi, S; Vastag, L; Larrabee, YC; Personick, ML; Schaberg, KB; Fowler, BJ; Sandwick, RK; Rawji, G.
"Importance of platinum(II)-assisted platinum(IV) substitution for the oxidation of guanosine derivatives by platinum(IV) complexes,"
INORGANIC CHEMISTRY,
v.47,
2008,
p. 1352
- 1360.
Munanairi, A; O'Banion, SK; Gamble, R; Breuer, E; Harris, AW; Sandwick, RK.
"The multiple Maillard reactions of ribose and deoxyribose sugars and sugar phosphates,"
CARBOHYDRATE RESEARCH,
v.342,
2007,
p. 2575
- 2592.
(Showing: 1 - 4 of 4).
Please report errors in award information by writing to: awardsearch@nsf.gov.
