Award Abstract #0215663
MRI: Acquisition of LC-MS for Chemistry and Biochemistry Undergraduate Research
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NSF Org: |
CHE
Division of Chemistry
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Initial Amendment Date: |
July 12, 2002 |
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Latest Amendment Date: |
July 12, 2002 |
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Award Number: |
0215663 |
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Award Instrument: |
Standard Grant |
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Program Manager: |
Robert L. Kuczkowski
CHE Division of Chemistry
MPS Directorate for Mathematical & Physical Sciences
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Start Date: |
August 1, 2002 |
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Expires: |
July 31, 2005 (Estimated) |
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Awarded Amount to Date: |
$153443 |
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Investigator(s): |
Kate Graham kgraham@csbsju.edu (Principal Investigator)
Michael Ross (Co-Principal Investigator)
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Sponsor: |
Saint John's University
Institutional Advancement
Collegeville, MN 56321 320/363-2596
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NSF Program(s): |
MAJOR RESEARCH INSTRUMENTATION
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Field Application(s): |
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Program Reference Code(s): |
EGCH, BIOT, 9198, 9184
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Program Element Code(s): |
1189
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ABSTRACT
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With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Saint John's University will acquire a liquid chromatograph with mass spectrometric detection, including atmospheric pressure chemical ionization and electrospray probes. This equipment will enhance research in a number of areas including a) isolation of bioactive natural products; b) quantification of pesticides and pesticide residues in the Sauk River watershed; c) analysis of biological mechanisms for drug resistance; d) modeling a trinuclear site in multicopper oxidases; e) oxidized LDL studies; f) DNA repair in Saccharomyces cerevisiae; g) identification of endothelial proteins involved in tight junction formation; and h) vitamin K status in female athletes.
Liquid chromatography with mass spectrometric detection (LC-MS) is an extremely powerful technique used for the separation and analysis of complex mixtures. It has become almost indispensable in industry; therefore, it will be crucial in the preparation of students for careers in industry or graduate school. This instrument will also be used by students at the College of Saint Benedict (an all women's college) and students at Saint Cloud State University.
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