Projects

NUTRITIONAL MODULATION OF BRAIN AGING AND COGNITIVE DECLINE Appropriated (D)   Accession Number: 408433

THE EFFECTS OF RASPBERRIES ON COGNITION AND NEURONAL COMMUNICATION IN AGING: MECHANISTIC CONSIDERATIONS Reimbursable (R)   Accession Number: 413145

THE ROLE OF DIETARY ANTIOXIDANTS AND AGING IN THE DELETERIOUS EFFECTS OF OXIDATIVE AND INFLAMMATORY INSULTS VIA HEAVY PARTICLE Reimbursable (R)   Accession Number: 407869

AGE-ACCELERATED EFFECTS OF HEAVY PARTICLES: EFFECTS OF NUTRITIONAL SUPPLEMENTATION WITH BERRYFRUITS Reimbursable (R)   Accession Number: 411913

MECHANISMS INVOLVED IN THE BENEFICIAL EFFECTS OF THORNLESS ERECT SWEET (TES) BLACKBERRIES ON NEURONAL AGING AND BEHAVIOR Trust (T)   Accession Number: 411139

THE EFFECTS OF WALNUTS ON COGNITION AND NEURONAL COMMUNICATION IN AGING: POSSIBLE SYNERGISTIC EFFECTS WITH BLUEBERRIES Trust (T)   Accession Number: 409685

THE ROLE OF STRAWBERRIES ON COGNITION, MOTOR BEHAVIOR, NEURONAL FUNCTION AND MICROGLIAL ACTIVITY IN AGING: REDUCTIONS IN STRESS MEDIATORS Trust (T)   Accession Number: 412439

THE EFFECTS OF CONCORD, NIAGRA, AND THOMPSON GRAPE JUICES ON COGNITIVE AND MOTOR DEFICITS IN AGING Trust (T)   Accession Number: 406593

THE EFFECTS OF STRAWBERRIES ON COGNITION AND NEURONAL COMMUNICATION IN AGING: MECHANISTIC CONSIDERATIONS Trust (T)   Accession Number: 409148

MECHANISMS INVOLVED IN THE BENEFICIAL EFFECTS OF BLUEBERRIES ON NEURONAL AGING AND BEHAVIOR Trust (T)   Accession Number: 410301

THE EFFECTS OF POMEGRANATES ON COGNITIVE AND MOTOR DEFICITS IN AGING Trust (T)   Accession Number: 407875

MECHANISMS INVOLVED IN THE BENEFICIAL EFFECTS OF BLUEBERRIES ON NEURONAL AGING AND BEHAVIOR Trust (T)   Accession Number: 410302

Publications

Effects of Berry Fruits on Neurocognitive Deficits Produced by Exposure to Space Radiation - (Book/Chapter)

Rabin, B.M., Joseph, J.A., Shukitt Hale, B. 2008. Effects of Berry Fruits on Neurocognitive Deficits Produced by Exposure to Space Radiation. In: Arora, R. Herbal Radiomodulators Applications in Medicine, Homeland Defence and Space. Wallingford, UK: Institute of Nuclear Medicine and Allied Sciences. p.151-161.

Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus - (Peer Reviewed Journal)

Shukitt Hale, B., Lau, F.C., Carey, A.N., Galli, R.L., Spangler, E.L., Ingram, D.K., Joseph, J.A. 2008. Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus. Nutritional Neuroscience. 11(4):172-182.

"Brainberries" and Aging - (Other)

Joseph, J.A., Shukitt Hale, B. 2008. "Brainberries" and Aging. Clinical Nutrition Insight.34:1-4.

Berry Fruit Supplementation in the Aging Brain - (Review Article)

Shukitt Hale, B., Lau, F.C., Joseph, J.A. 2008. Berry Fruit Supplementation in the Aging Brain. Journal of Agriculture and Food Chemistry. 56:636-641.

Polyphenols and Polyunsaturate Fatty Acids: The Pollyanna's of Age-Related Cognitive Decline, Neurodegenerative Disease - (Book/Chapter)

Joseph, J.A., Smith, M.A., Perry, G., Shukitt Hale, B. 2008. Polyphenols and Polyunsaturate Fatty Acids: The Pollyanna's of Age-Related Cognitive Decline, Neurodegenerative Disease. In Coulston, A.M. and Boushey, C.J., editors. Nutrition in the Prevention and Treatment of Disease. 2nd edition. San Diego: Elsevier. p. 269-287.

Blueberries and Human Health: A Review of Current Research - (Peer Reviewed Journal)

Kalt, W., Joseph, J.A., Shukitt Hale, B. 2007. Blueberries and Human Health: A Review of Current Research. Journal of American Pomological Society. 61:151-160.

Aging modifies brain region-specific vulnerability to experimental oxidative stress induced by low dose hydrogen peroxide - (Peer Reviewed Journal)

Denissova, N., Rosenberg, I., Shukitt Hale, B., Bielinski, D., Dallal, G., Joseph, J.A. 2007. Aging modifies brain region-specific vulnerability to experimental oxidative stress induced by low dose hydrogen peroxide. American Aging Association. 29:191-203.

Dietary modulation of the effects of exposure to 56FE particles - (Peer Reviewed Journal)

Rabin, B.M., Joseph, J.A., Shukitt Hale, B., Carey, A.N. 2007. Dietary modulation of the effects of exposure to 56FE particles. Advances in Space Research. 40(4):576-580.

A blueberry-enriched diet provides cellular protection against oxidative stress and attenuates a kainate-induced learning impairment in rats - (Peer Reviewed Journal)

Duffy, K.B., Spangler, E.L., Devan, B.D., Guo, Z., Bowker, J.L., Janas, A.M., Hagapanos, A., Minor, R.K., Decabo, R., Mouton, P.R., Shukitt Hale, B., Joseph, J.A., Ingram, D.K. 2008. A blueberry-enriched diet provides cellular protection against oxidative stress and attenuates a kainate-induced learning impairment in rats. Neurobiology of Aging. 29:1680-1689.

Amphetamine-Induced Taste Aversion Learning in Young and Old F-344 Rats Following Exposure to 56Fe Particles - (Peer Reviewed Journal)

Carrihill-Knoll, K.L., Rabin, B.M., Shukitt Hale, B., Joseph, J.A., Carey, A. 2007. Amphetamine-Induced Taste Aversion Learning in Young and Old F-344 Rats Following Exposure to 56Fe Particles. Pharmacology, Biochemistry and Behavior. 29(2):69-76.

Cytoprotective effects of anthocyanins and other phenolic fractions of Boysenberry and blackcurrant on dopamine and amyloid Beta induced oxidative stress in transfected COS-7 cells - (Peer Reviewed Journal)

Ghosh, D., Mcghie, T.K., Fisher, D.R., Joseph, J.A. 2007. Cytoprotective effects of anthocyanins and other phenolic fractions of Boysenberry and blackcurrant on dopamine and amyloid Beta induced oxidative stress in transfected COS-7 cells. Journal of the Science of Food and Agriculture. 87:2061-2067.

Fruit Polyphenols and their effects on Neuronal Signaling and Behavior in Senescence. - (Book/Chapter)

Joseph, J.A., Shukitt Hale, B., Lau, F.C. 2007. Fruit Polyphenols and their effects on Neuronal Signaling and Behavior in Senescence. Annals of the New York Academy of Sciences. 1100:470-485.

Dopamine and ABeta-induced Stress Signaling and Decrements in CA2+ Buffering in Primary Neonatal Hippocampal Cells are Antagonized by Blueberry Extract - (Peer Reviewed Journal)

Joseph, J.A., Carey, A.N., Brewer, G.J., Lau, F.C., Fisher, D.R. 2007. Dopamine and ABeta-induced Stress Signaling and Decrements in CA2+ Buffering in Primary Neonatal Hippocampal Cells are Antagonized by Blueberry Extract. Journal of Alzheimer's Disease. 11:433-446.

Inhibitory effects of Blueberry Extract on the Production of Inflammatory Mediators in LPS-activated BV2 Microglia - (Peer Reviewed Journal)

Lau, F.C., Bielinski, D., Joseph, J.A. 2007. Inhibitory effects of Blueberry Extract on the Production of Inflammatory Mediators in LPS-activated BV2 Microglia. Journal of Neuroscience Research. 85:1010-1017.

Interaction between age and exposure to 56Fe particles on behavior and neurochemistry - (Peer Reviewed Journal)

Carey, A.N., Shukitt Hale, B., Rabin, B.M., Joseph, J.A. 2007. Interaction between age and exposure to 56Fe particles on behavior and neurochemistry. Advances in Space Research. 39:987-993.

Elevated plus-maze performance of Fischer-344 rats as a function of age and of exposure to 56Fe particles - (Peer Reviewed Journal)

Rabin, B.M., Carrihill-Knoll, K.L., Carey, A.N., Shukitt Hale, B., Joseph, J.A., Foster, B.C. 2007. Elevated plus-maze performance of Fischer-344 rats as a function of age and of exposure to 56Fe particles. Advances in Space Research. 39:981-986.

Exposure to 56Fe irradiation accelerates normal brain aging and produces deficits in spatial learning and memory - (Review Article)

Shukitt Hale, B., Casadesus, G., Carey, A.N., Rabin, B.M., Joseph, J.A. 2007. Exposure to 56Fe irradiation accelerates normal brain aging and produces deficits in spatial learning and memory. Advances in Space Research. 39:1087-1092.

Nutritional Intervention in Brain Aging: Reducing the Effects of Inflammation and Oxidative Stress - (Book/Chapter)

Lau, F.C., Shukitt Hale, B., Joseph, J.A. 2007. Nutritional Intervention in Brain Aging: Reducing the Effects of Inflammation and Oxidative Stress. Inflammation in the Pathogenesis of Chronic Diseases:The COX-2 controversy. Subcellular Biochemistry. Volume 42. New York, NY:Springer Publication. p.299-318.

Nutritional Interventions in Aging and Age-Associated Diseases - (Proceedings/Symposium)

Roth, G.S., Ingram, D.K., Joseph, J.A. 2007. Nutritional Interventions in Aging and Age-Associated Diseases. 3rd International Conference on Healthy Ageing and Longevity. Annals of the New York Academy of Sciences. 1114:369-371.

BENEFICIAL EFFECTS OF FRUIT EXTRACTS ON NEURONAL FUNCTION AND BEHAVIOR IN A RODENT MODEL OF ACCELERATED AGING - (Peer Reviewed Journal)

Shukitt Hale, B., Carey, A.N., Jenkins, D., Rabin, B.M., Joseph, J.A. 2007. Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging. Neurobiology of Aging.28:1187-1194.

Beneficial effects of berryfruit polyphenols on neuronal behavioral aging - (Review Article)

Lau, F.C., Shukitt Hale, B., Joseph, J.A. 2006. Beneficial effects of berryfruit polyphenols on neuronal behavioral aging. Journal of the Science of Food and Agriculture.86:2251-2255.

Dopamine-Induced Stress Signaling in COS-7 Cells Transfected With Selectively Vulnerable Muscarinic Receptor Subtypes is Partially Mediated Via the i3 Loop and Antagonized By Blueberry Extract - (Peer Reviewed Journal)

Joseph, J.A., Fisher, D.R., Carey, A.N., Bielinski, D.F. 2006. Dopamine-Induced Stress Signaling in COS-7 Cells Transfected With Selectively Vulnerable Muscarinic Receptor Subtypes is Partially Mediated Via the i3 Loop and Antagonized By Blueberry Extract. Journal of Alzheimer's Disease. 10:423-437.

DIETARY SUPPLEMENTATION WITH BLUEBERRY EXTRACT IMPROVES SURVIVAL OF TRANSPLANTED DOPAMINE NEURONS - (Peer Reviewed Journal)

Mcguire, S.O., Sortwell, C.E., Shukitt Hale, B., Joseph, J.A., Hejna, M.J., Collier, T.J. 2006. Dietary supplementation with blueberry extract improves survival of transplanted dopamine neurons. Nutritional Neuroscience. 9(5/6): 251-258.

BHT blocks NfkB activation and Ethanol-Induced Brain Damage - (Peer Reviewed Journal)

Crews, F.T., Nixon, K., Kim, D., Joseph, J.A., Shukitt Hale, B., Qin, L., Zou, J. 2006. Bht blocks nfkb activation and ethanol-induced brain damage. Alcoholism: Clinical and Experimental.30(11):1938-1949.

A blueberry-enriched antioxidant diet reduces an age-related deficit in one trial per day discriminative reward learning - (Abstract)

Goyarzu, P., Malin, D.H., Moon, W.D., Moy, E., Moy, D., Jennings, R., Lippold, S., Shukitt Hale, B., Joseph, J.A. 2006. A blueberry-enriched antioxidant diet reduces an age-related deficit in one trial per day discriminative reward learning. Society for Neuroscience Abstracts and Proceedings.

COUPLING OF NEURONAL FUNCTION TO OXYGEN AND GLUCOSE METABOLISM THROUGH CHANGES IN NEUROTRANSMITTER DYNAMICS AS REVEALED WITH AGING, HYPOGLYCEMIA AND HYPOXIA - (Book/Chapter)

Joseph, J.A., and Gibson, G.E. 2007. Coupling of neuronal function to oxygen and glucose metabolism through changes in neurotransmitter dynamics as revealed with aging, hypoglycemia and hypoxia. In Gibson, G.E. and Dienel, G., editors. Handbook of Neurochemistry and Molecular Biology. 3rd edition. Volume 5. New York, NY: Springer. p.297-320.

BLUEBERRY EXTRACT ALTERS OXIDATIVE STRESS-MEDIATED SIGNALING IN COS-7 CELLS TRANSFECTED WITH SELECTIVELY VULNERABLE MUSCARINIC RECEPTOR SUBTYPES - (Peer Reviewed Journal)

Joseph, J.A., Fisher, D.R., Bielinski, D. 2006. Blueberry extract alters oxidative stress-mediated signaling in cos-7 cells transfected with selectively vulnerable muscarinic receptor subtypes. Journal of Alzheimer's Disease. 9(1):35-42.

Blueberries and the Aging Brain: Beyond Antioxidants - (Trade Journal)

Mark, D.A., Shukitt Hale, B., Joseph, J.A. 2006. Blueberries and the Aging Brain: Beyond Antioxidants. The Food Journal.49(2):50-55.

BLUEBERRY POLYPHENOLS INCREASE CAENORHABDITIS ELEGANS SURVIVAL DURING AGING AND THERMAL STRESS - (Peer Reviewed Journal)

Wilson, M.A., Shukitt Hale, B., Kalt, W., Ingram, D.K., Joseph, J.A., Wolkow, C.A. 2006. Blueberry polyphenols increase caenorhabditis elegans survival during aging and thermal stress. Aging Cell. (5):55-68

AGE RELATED NEURONAL AND BEHAVIORAL DEFICITS ARE IMPROVED BY POLYPHENOL RICH BLUEBERRY SUPPLEMENTATION - (Book/Chapter)

Lau, F.C., Shukitt Hale, B., Joseph, J.A. 2005. Age related neuronal and behavioral deficits are improved by polyphenol rich blueberry supplementation. CRC Press. p. 499.

THE BENEFICIAL EFFECTS OF FRUIT POLYPHENOLS ON BRAIN AGING - (Review Article)

Lau, F.C., Shukitt Hale, B., Joseph, J.A. 2005. The beneficial effects of fruit polyphenols on brain aging. Neurobiology of Aging. 26S:S128-S132.

EFFECTS OF CONCORD GRAPE JUICE ON COGNITIVE AND MOTOR DEFICITS IN AGING - (Peer Reviewed Journal)

Shukitt Hale, B., Carey, A.N., Simon, L.E., Mark, D.A., Joseph, J.A. 2006. Effects of Concord Grape Juice on Cognitive and Motor Deficits in Aging. Nutrition. 22:295-302.

BLUEBERRY EXTRACT INHIBITS DA-OR AB-INDUCED DECREMENTS IN CALCIUM FLUX IN PRIMARY HIPPOCAMPAL CELLS - (Abstract)

Joseph, J.A., Fisher, D.R. 2005. Blueberry extract inhibits da-or ab-induced decrements in calcium flux in primary hippocampal cells. Society for Neuroscience Abstracts and Proceedings. Abstract No. 93.6.

INHIBITORY EFFECTS OF BLUEBERRY POLYPHENOLS ON THE PRODUCTION OF PROINFLAMMATORY MEDIATORS IN ACTIVATED MICROGLIAL CELLS - (Abstract)

Lau, F.C., Bielinski, D.F., Joseph, J.A. 2005. Inhibitory effects of blueberry polyphenols on the production of proinflammatory mediators in activated microglial cells. Society for Neuroscience Abstracts and Proceedings. Abstract No. 337.17

BLUEBERRY EXTRACT PREVENTS C-2 CERAMIDE DISRUPTION OF CA2+ BUFFERING IN MACHR-TRANSFECTED COS-7 CELLS - (Abstract)

Fisher, D.R., Bielinski, D.F., Joseph, J.A. 2005. Blueberry extract prevents c-2 ceramide disruption of ca2+ buffering in machr-transfected cos-7 cells. Society for Neuroscience Abstracts and Proceedings. Abstract No. 93.7

EFFECTS OF AGE AND EXPOSURE TO GOUND-BASED MODELS OF COSMIC RAYS ON ELEVATED PLUS MAZE PERFORMANCE IN RATS - (Abstract)

Carrihill-Knoll, K.L., Maloney, B.K., Rabin, B.M., Shukitt Hale, B., Joseph, J.A., Carey, A.N. 2005. Effects of age and exposure to gound-based models of cosmic rays on elevated plus maze performance in rats. Society for Neuroscience Abstracts and Proceedings. Abstract No. 656.10.

DIFFERENTIAL EFFECTS OF BLUEBERRY EXTRACT PREPARATIONS ON COGNTIVE AND MOTOR FUNCTION IN AGING: THE ROLE OF PHENOLICS - (Abstract)

Shukitt Hale, B., Carey, A.N., Kalt, W., Mcdonald, J., Vinqvist, M., Joseph, J.A. 2005. Differential effects of blueberry extract preparations on cogntive and motor function in aging: the role of phenolics. Society for Neuroscience Abstracts and Proceedings. Abstract No. 93.5.

AGE-RELATED CHANGES IN NEUTRAL SPHINGOMYELIN-SPECIFIC PHOSPHOLIPASE C ACTIVITY IN STRIATUM, HIPPOCAMPUS, AND FRONTAL CORTEX: IMPLICATION FOR SENSITIVITY TO STRESS AND INFLAMMATION - (Peer Reviewed Journal)

Crivello, N.A., Rosenberg, I.H., Dallal, G.E., Bielinski, D., Joseph, J.A. 2005. Age-related changes in neutral sphingomyelin-specific phospholipase c activity in striatum, hippocampus, and frontal cortex: implication for sensitivity to stress and inflammation. Neurochemistry International. 47(8): 573-579.

OXIDATIVE STRESS AND INFLAMMATION IN BRAIN AGING: NUTRITIONAL CONSIDERATIONS - (Review Article)

Joseph, J.A., Shukitt Hale, B., Casadesus, G., Fisher, D.R. 2005. Oxidative stress and inflammation in brain aging: nutritional considerations. Neurochemical Research. Volume(30):927-935

THE EFFECTS OF ANTIOXIDANTS IN THE SENESCENT AUDITORY CORTEX - (Peer Reviewed Journal)

De Rivera, C., Shukitt Hale, B., Joseph, J.A., Mendelson, J.R. 2006. The effects of antioxidants in the senescent auditory cortex. Neurobiology of Aging. 27(7):1035-1044.

DIETARY SUPPLEMENTATION WITH FRUIT POLYPHENOLICS AMELIORATES AGE-RELATED DEFICITS IN BEHAVIOR AND NEURONAL MARKERS OF INFLAMMATION AND OXIDATIVE STRESS - (Peer Reviewed Journal)

Shukitt Hale, B., Meterko, V., Carey, A.N., Bielinski, D., Mcguie, T., Galli, R., Joseph, J.A. 2005. Dietary supplementation with fruit polyphenolics ameliorates age-related deficits in behavior and neuronal markers of inflammation and oxidative stress. Age. 2005, 27, 49-57.

REVERSING THE DELETERIOUS EFFECTS OF AGING ON NEURONAL COMMUNICATION AND BEHAVIOR: THE BENEFICIAL PROPERTIES OF FRUIT POLYPHENOLICS - (Peer Reviewed Journal)

Joseph, J.A., Shukitt Hale, B., Casadesus, G. 2005. Reversing the deleterious effects of aging on neuronal communication and behavior: the beneficial properties of fruit polyphenolics. American Journal of Clinical Nutrition 2005, 81 (Suppl.) 313S-316S

OXIDATIVE ADAPTATION IN AGING AND ALZHEIMER DISEASE: THE ROLES OF AMYLOID AND TAU - (Book/Chapter)

Lee, H., Zhu, X., Drew, K.L., Joseph, J.A., Nunomura, A., Hirai, K., Takeda, A., Perry, G., Smith, M.A. 2005. Oxidative adaptation in aging and alzheimer disease: the roles of amyloid and tau. In: Hiramatsu, M., Yoshikawa, T., Packer, L. editors. Molecular interventions in Lifestyle-Related Diseases. Boca Raton, FL: CRC Press Taylor and Francis Group, LLC. p. 117-125.

EFFECT OF DIET ON THE DISRUPTION OF OPERANT RESPONDING AT DIFFERENT AGES FOLLOWING EXPOSURE TO FE56 PARTICLES - (Peer Reviewed Journal)

Rabin, B.M., Carrihill-Knoll, K.L., Carey, A.N., Shukitt Hale, B., Joseph, J.A. 2005. Effect of diet on the disruption of operant responding at different ages following exposure to fe56 particles. Age. 205, 27, 69-73.

DIET AS A FACTOR IN BEHAVIORAL RADIATION PROTECTION FOLLOWING EXPOSURE TO HEAVY PARTICLES - (Peer Reviewed Journal)

Rabin, B.M., Shukitt Hale, B., Joseph, J.A., Tood, P. 2005. Diet as a factor in behavioral radiation protection following exposure to heavy particles. American Society for Gravitation and Space Biology 18(2)June 2005.

ANTHOCYANINS IN AGED BLUEBERRY-FED RATS ARE FOUND CENTRALLY AND MAY ENHANCE MEMORY - (Peer Reviewed Journal)

Andres-Lacueva, C., Shukitt Hale, B., Galli, R.L., Jaurengui, O., Lamuela-Raventos, R.M., Joseph, J.A. 2005. Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutritional Neuroscience, April 2005:8(2): 111-120.

BLUEBERRY SUPPLEMENTED DIET REVERSES AGE-RELATED DECLINE IN HIPPOCAMPAL HSP70 NEUROPROTECTION - (Peer Reviewed Journal)

Galli, R.L., Bielinski, D.F., Szprengiel, A., Shukitt Hale, B., Joseph, J.A. 2006. Blueberry supplemented diet reverses age-related decline in hippocampal hsp70 neuroprotection. Neurobiology of Aging 27 (2006)344-350.

EFFECTS OF AGE AND DIET ON THE HEAVY PARTICLE-INDUCED DISRUPTIONS OF OPERANT RESPONDING PRODUCED BY A GROUND-BASED MODEL FOR EXPOSURE TO COSMIC RAYS - (Peer Reviewed Journal)

Rabin, B.M., Joseph, J.A., Shukitt Hale, B., 2005. Effects of age and diet on the heavy particle-induced disruptions of operant responding produced by a ground-based model for exposure to cosmic rays. Brain Research 1036(2005) 122-129.

A LONGITUDINAL STUDY OF OPERANT RESPONDING IN RATS IRRADIATED AT TWO MONTHS OF AGE - (Peer Reviewed Journal)

Rabin, B.M., Joseph, J.A., Shukitt Hale, B. 2005. A longitudinal study of operant responding in rats irradiated at two months of age. Radiation Research. 164:552-555.

MODULATION OF HIPPOCAMPAL PLASTICITY AND COGNITIVE BEHAVIOR BY SHORT-TERM BLUEBERRY SUPPLEMENTATION IN AGED RATS - (Peer Reviewed Journal)

Casadesus, G., Shukitt Hale, B., Stellwagen, H.M., Zhu, X., Lee, H., Smith, M.A., Joseph, J.A. 2004. Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats. Nutritional Neuroscience, Volume 7 Number 5/6 (October/December 2004), pp.309-316

HIPPOCAMPAL NEUROGENESIS AND PSA-NCAM EXPRESSION FOLLOWING EXPOSURE TO 56FE PARTICLES MIMICS THAT SEEN DURING AGING - (Peer Reviewed Journal)

Casadesus, G., Stellwagen, H.M., Shukitt Hale, B., Rabin, B.M., Joseph, J.A. 2005. Hippocampal neurogenesis and psa-ncam expression following exposure to 56fe particles mimics that seen during aging. Gerontology Journal. 40 249-254

FLAVONOIDS AND THE BRAIN: INTERACTIONS AT THE BLOOD BRAIN BARRIER AND THEIR PHYSIOLOGICAL EFFECT ON THE CNS - (Review Article)

Youdim, K.A., Shukitt Hale, B., Joseph, J.A. 2004. Flavonoids and the brain: interactions at the blood brain barrier and their physiological effect on the cns. Free Radical Biology and Medicine, VOL 37, NO11 PP. 1683-1693.

THE BENEFICIAL EFFECTS OF FRUIT AND VEGETABLE SUPPLEMENTATION ON NEURONAL SIGNALING AND BEHAVIOR IN AGING: BEYOND ANTIOXIDANTS - (Book/Chapter)

Joseph, J.A., Shukitt Hale, B., Casadesus, G. 2006. The beneficial effects of fruit and vegetable supplementation on neuronal signaling and behavior in aging: beyond antioxidants. In: Stagg, J.J. and Foster, J. G. Editors. Nutrients, Stress and Medical Disorders. Totowa, MJ:Humana Press. p. 67-82

FRUIT POLYPHENOLS PREVENT INFLAMMATORY MEDIATED DECREMENTS IN COGNITION - (Proceedings/Symposium)

Shukitt Hale, B., Carey, A.N., Belinski, D., Lau, F.C., Galli, R.L., Spangler, E.L., Ingram, D.K., Joseph, J.A. 2004. Fruit polyphenols prevent inflammatory mediated decrements in cognition. Soc. Neurosci. Abs. 2004, 30,565.5.

NUTRITION AND COMMUNICATION IN THE AGED BRAIN: CAN YOU HEAR US NOW? - (Peer Reviewed Journal)

Joseph, J.A., Shukitt Hale, B., Smith, M. 2004. Nutrition and communication in the aged brain: can you hear us now? Acarology International Congress Proceedings.

BLUEBERRY EXTRACT INHIBITS DA-INDUCED INCREASES IN MAPK SIGNALING IN MUSCARINIC M1 AND M3-TRANSFECTED COS-7 CELLS - (Proceedings/Symposium)

Joseph, J.A., Bielinski, D., Fisher, D.R. 2004. Blueberry extract inhibits DA-induced increases in MAPK signaling in Muscarinic M1 and M3-transfected COS-7 cells. Soc.Neurosci. Abs. 2004, 30, 1017.17.

THE M3 MUSCARINIC RECEPTOR I3 DOMAIN CONFERS OXIDATIVE STRESS PROTECTION ON CALCIUM REGULATION IN TRANSFECTED COS-7 CELLS - (Peer Reviewed Journal)

Joseph, J.A., Fisher, D.R., Carey, A.N., Szprengiel, A. 2004. The m3 muscarinic receptor i3 domain confers oxidative stress protection on calcium regulation in transfected cos-7 cells. Aging Cell (2004)3, pp263-271.

FRUIT EXTRACTS ANTAGONIZE AB-OR DA-INDUCED DEFICITS IN CA2+ FLUX IN M1-TRANSFECTED COS-7 CELLS - (Peer Reviewed Journal)

Joseph, J.A., Fisher, D.R., Carey, A.N. 2004. Fruit extracts antagonize ab-or da-induced deficits in ca2+ flux in m1-transfected cos-7 cells. Journal of Alzheimer's Disease 6(2004) 403-411.

THE BENEFICIAL PROPERTIES OF FRUIT POLYPHENOLS ON NEURONAL COMMUNICATION AND BEHAVIOR IN AGING - (Book/Chapter)

Joseph, J.A., Shukitt Hale, B., Casadesus, G. 2004. The beneficial properties of fruit polyphenols on neuronal communication and behavior in aging. In: Stagg, J.J., Foster, J.G. editors. Medicinal and Aromatic Plants: Production, Business and Applications. West Virginia: Mountain State University Press. p.18-30.

DIETARY SUPPLEMENTATION WITH BLUEBERRY EXTRACT DECREASES INFLAMMATION AFTER BRAIN INJURY IN RATS: IMPLICATIONS FOR NEURAL TRANSPLANTATION - (Proceedings/Symposium)

Mcguire, S.O., Hejna, M.J., Shukitt Hale, B., Joseph, J.A., Collier, T.J., Lorens, S.A. Dietary supplementation with blueberry extract decreases inflammation after brain injury in rats: implications for neural transplantation. 2004 Society for Neuroscience Abstracts and Proceedings.

BLUEBERRY SUPPLEMENTED DIET: EFFECTS ON OBJECT RECOGNITION MEMORY & NUCLEAR FACTOR KAPPA B LEVELS IN AGED RATS - (Peer Reviewed Journal)

Goyarzu, P., Malin, D.H., Lau, F.C., Taglialatela, G., Moon, W.D., Jennings, R., Moy, E., Moy, D., Lippold, S., Shukitt Hale, B., Joseph, J.A. 2004. Blueberry supplemented diet: effects on object recognition memory & nuclear factor kappa b levels in aged rats. Nutritional Neuroscience. 7(2):75-83.

DIFFERENT PERSPECTIVES ON THE AMYLOID-B CASCADE HYPOTHESIS - (Book/Chapter)

Lee, H., Casadesus, G., Zhu, X., Tabaton, M., Joseph, J.A., Perry, G., Smith, M. 2004. Different perspectives on the amyloid-b cascade hypothesis. Journal of Alzheimer's Disease.

FRUIT POLYPHENOLICS AND SIGNALING IN THE AGED BRAIN:ALTERING MOTOR AND COGNITIVE DEFICITS - (Book/Chapter)

Joseph, J.A., Shukitt Hale, B. 2004. Fruit polyphenolics and signaling in the aged brain:altering motor and cognitive deficits. In: Ozben, T., Chevion. M., editors. Frontiers in Aging and Neurodegenerative Disorders: Fundamental Aspects, Clinical Perspectives and New Insights. Amsterdam, The Netherlands:IOS Press. p. 170-181.

HEAVY PARTICLE IRRADIATION, NEUROCHEMISTRY AND BEHAVIOR: THRESHOLDS, DOSE-RESPONSE CURVES AND RECOVERY OF FUNCTION - (Peer Reviewed Journal)

Rabin, B.M., Joseph, J.A., Shukitt Hale, B. 2004. Heavy particle irradiation, neurochemistry and behavior: thresholds, dose-response curves and recovery of function. Advances in Space Research. 33:1330-1333.

THE EFFECTS OF HEAVY PARTICLE IRRADIATION ON EXPLORATION AND RESPONSE TO ENVIRONMENTAL CHANGE - (Peer Reviewed Journal)

Casadesus, G., Shukitt Hale, B., Cantuti-Castelvetri, I., Rabin, B.M., Joseph, J.A. 2004. The effects of heavy particle irradiation on exploration and response to environmental change. Advances in Space Research.

NUTRITIONAL ANTIOXIDANTS, VITAMINS, COGNITION AND NEURODEGENERATIVE DISEASE - (Book/Chapter)

Martin, A., Smith, M.A., Perry, G., Joseph, J.A. 2004. Nutritional antioxidants, vitamins, cognition and neurodegenerative disease. Principles of Gender Specific Medicine, Volume 2. Elsevier: San Diego, 2004, 813-823.

ALZHEIMER DISEASE: CAUSES, CONSEQUENCES AND SURPRISES - (Other)

Smith, M.A., Zhu, X., Casadesus, G., Aliev, G., Ogawa, O., Nunomura, A., Takeda, A., Joseph, J.A., Peterson, R.B., Perry, G., 2003. Alzheimer disease: causes, consequences and surprises. Biogerontology 2003, 4 (Suppl 1): 88-89.

EFFECTS OF ANTIOXIDANT DIETS ON AGE- AND HEAVY PARTICLE-INDUCED DISRUPTION OF OPERANT RESPONDING IN RATS - (Abstract)

Rabin, B.M., Jenkins, D.G., Joseph, J.A., Shukitt Hale, B. 2003. Effects of antioxidant diets on age- and heavy particle-induced disruption of operant responding in rats. Society for Neuroscience Abstracts and Proceedings.

MECHANISMS INVOLVED IN BLUEBERRY ENHANCEMENTS OF MOTOR AND COGNITIVE FUNCTION IN YOUNG AND OLD RATS - (Abstract)

Shukitt Hale, B., Carey, A.N., Casadesus, G., Galli, R.L., Joseph, J.A. 2003. Mechanisms involved in blueberry enhancements of motor and cognitive function in young and old rats. Soc. Neurosci. Abs. 2003, 29. 633.14

AGE-RELATED INCREASE IN BRAIN NFK-B IS ATTENUATED BY BLUEBERRY-ENRICHED ANTIOXIDANT DIET - (Other)

Goyarzu, P., Lau, F.C., Kaufmann, J., Jennings, R., Taglialatela, G., Shukitt Hale, B., Joseph, J.A., Malin, D. Age-related increase in brain nfk-b is attenuated by blueberry-enriched antioxidant diet. Soc. Neurosci. Abs. 2003, 29, 98.3

RATS FED A BLUEBERRY-ENRICHED DIET EXHIBIT GREATER PROTECTION AGAINST A KAINATE-INDUCED LEARNING IMPAIRMENT - (Abstract)

Spangler, E., Duffy, K., Devon, B., Guo, Z., Bowker, J., Shukitt Hale, B., Joseph, J.A., Ingram, D.K. 2003. Rats fed a blueberry-enriched diet exhibit greater protection against a kainate-induced learning impairment. Soc. Neurosci. Abs. 2003, 29, 638.12.

AGE-RELATED INCREASED IN BRAIN NF-KB IS ATTENUATED BY BLUEBERRY-ENRICHED ANTIOXIDANT DIET - (Abstract)

Goyarzu, P., Lau, F.C., Kaufmann, J., Jennings, R., Taglialatela, G., Shukitt Hale, B., Joseph, J.A., Malin, D. 2003. Age-related increased in brain nf-kb is attenuated by blueberry-enriched antioxidant diet. Society for Neuroscience Abstracts and Proceedings.

MUSCARININC RECEPTOR SUBTYPE DETERMINES VULNERABILITY TO AMYLOD BETA TOXICITY IN TRANSFECTED COS-7 CELLS - (Peer Reviewed Journal)

Joseph, J.A., and Fisher, D.R. Muscarinic receptor subtype determines vulnerability to amyloid beta toxicity in transfected COS 7 cells. J. Alz. Dis. 2003. 5: 197-208.

EAT LESS, EAT BETTER, AND LIVE LONGER: DOES IT WORK AND IS IT WORTH IT? THE ROLE OF DIET IN AGING AND DISEASE - (Book/Chapter)

Casadesus, G., Perry, G., Joseph, J.A., Smith, M.A. 2004. Eat less, eat better, and live longer: does it work and is it worth it? the role of diet in aging and disease. In: edited by Post, S.G. and Binstock, R.H. The Fountain of Youth: Cultural, Scientific and Ethical Perspectives on a Biomedical Goal. New York:Oxford University Press. p. 463.

PHYTOCHEMICALS IN FOODS AND EVERAGES: EFFECTS ON THE CNS - (Other)

Shukitt Hale, B., Carey, A.N., Joseph, J.A. Phytochemicals in foods and everages: Effects on the Central Nervous System. In lieberman, H.R., Kanarek, R.B., and Prasad, C.eds. Nutritional Neuroscience. CRC Press, Taylor & Francis Group, LLC Boca Raton, FL, 2005, 393-404.

BLUEBERRY SUPPLEMENTATION ENHANCES SIGNALING AND PREVENTS BEHAVIORAL DEFICITS IN ALZHEIMER DISEASE MODEL - (Peer Reviewed Journal)

Joseph, J.A., Arendash, G., Gordon, M., Diamond, D., Shukitt Hale, B., and Morgan, D. Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr. Neurosci. 2003, 6: 153-162.

LONG-TERM CHANGES IN AMPHETAMINE-INDUCED REINFORCEMENT AND AVERSION IN RATS FOLLOWING EXPOSURE TO 56FE PARTICLES - (Peer Reviewed Journal)

Rabin, B.M., Joseph, J.A., and Shukitt-Hale, B. Long-term changes in amphetamine-induced reinforcement and aversion in rats following exposure to 56Fe particles. Adv. Space Res. 2003, 31: 127-133.

COGNITIVE DEFICITS INDUCED BY 56FE RADIATION EXPOSURE - (Peer Reviewed Journal)

Shukitt-Hale, B., Casadesus, G., Cantuti-Castelvetri, I., Rabin, B.M., and Joseph, J.A. Cognitive deficits induced by 56Fe radiation exposure. Adv. Space Res. 2003, 31: 119-126.

BRAIN SIGNALING AND BEHAVIORAL RESPONSES INDUCED BY EXPOSURE TO 56FE RADIATION - (Peer Reviewed Journal)

DENISOVA, N.A., SHUKITT HALE, B., RABIN, B., JOSEPH, J.A. BRAIN SIGNALING AND BEHAVIORAL RESPONSES INDUCED BY EXPOSURE TO 56FE RADIATION. RADIATION RESEARCH. 2002.158(6):725-34.

INTERACTION BETWEEN HEAVY PARTICLES IRRADIATION AND AGE IN THE DISRUPTION OF FIXED-RATION OPERANT RESPONDING IN RATS - (Other)

Rabin, B.M., Shukitt-Hale, B., Joseph, J.A., Buhler, L.L., Jenkins, D.G., and Eggleston, A.M. Interaction between heavy particle irradiation and age in the disruption of fixed - ratio operant responding in rats. Soc. Neurosci. Abs. 2002, 28, 889.11.

DIETARY SUPPLEMENTATION WITH BLUEBERRY EXTRACTS IMPROVES THE SURVIVAL AND FUNCTION OF GRAFTED EMBRYONIC DOPAMINE NEURONS IN RATS - (Other)

Mcguire, S.O., Shukitt Hale, B., Joseph, J.A., Sortwell, C.E., Fleming, M.F., Marchionini, D.M., Kanaan, N.M., Daley, B., Collier, T.J. 2002. Dietary supplementation with blueberry extracts improves the survival and function of grafted embryonic dopamine neurons in rats. Society for Neuroscience Abstracts and Proceedings.

POLYPHENOLICS CAN LOCALIZE WITHIN THE BRAINS OF AGED RATS FED A BLUEBERRY-SUPPLEMENTED DIET - (Abstract)

Shukitt-Hale, B., Andres-Lacueva, C., Galli, R.L., Jauregui, O., Lamuela-Raventos, R.M., and Joseph, J.A. Polyphenolics can localize within the brains of aged rats fed a blueberry - supplemented diet. Soc. Neurosci. Abs. 2002, 28, 294.6.

DIETARY SUPPLEMENTATION WITH FRUIT POLYPHENOLICS AMELIORATES AGE-RELATED DEFICITS IN BEHAVIOR AND NEURONAL MARKERS OF INFLAMMATION AND OXIDATIVE STRESS - (Other)

Galli, R.L., Shukitt Hale, B., Bielinski, D.F., Andres-Lacueva, C., Joseph, J.A. 2002. Dietary supplementation with fruit polyphenolics ameliorates age-related deficits in behavior and neuronal markers of inflammation and oxidative stress. Society for Neuroscience Abstracts and Proceedings.

MODULATION OF HIPPOCAMPAL NEUROGENESIS AND COGNITIVE PERFORMANCE IN THE AGED RAT: THE BLUEBERRY EFFECT - (Other)

Casadesus, G., Stellwagen, H., Szprengiel, A., Galli, R.L., Smith, M.A., Shukitt Hale, B., Joseph, J.A. 2002. Modulation of hippocampal neurogenesis and cognitive performance in the aged rat: the blueberry effect. Society for Neuroscience Abstracts and Proceedings.

EFFECTS OF HEAVY PARTICLES IRRADIATION AND DIET ON AMPHETAMINE- AND LITHIUM CHLORIDE-INDUCED TASTE AVOIDANCE LEARNING IN RATS - (Peer Reviewed Journal)

RABIN, B.M., SHUKITT HALE, B., SZPRENGIEL, A., JOSEPH, J.A. EFFECTS OF HEAVY PARTICLES IRRADIATION AND DIET ON AMPHETAMINE- AND LITHIUM CHLORIDE-INDUCED TASTE AVOIDANCE LEARNING IN RATS. BRAIN RESEARCH.853:31-6.

AMYLOID-2 AND OSERVE ANTIOXIDANT FUNCTIONS IN THE AGING AND ALZHEIMER BRAIN - (Peer Reviewed Journal)

Smith, M.A., Casadesus, G., Joseph, J.A., and Perry, G. Amyloid-ß and t serve antioxidant functions in the aging and Alzheimer brain. Free Rad. Biol. Med. 2002, 33: 1194-1199.

PHYTOCHEMICALS AND BRAIN AGING: A MULTIPLICITY OF EFFECTS - (Book/Chapter)

Youdim, K.A., Joseph, J.A. 2003. Phytochemicals and brain aging: a multiplicity of effects. Book Chapter.

AMYLOID-2: A (LIFE) PRESERVER FOR THE BRAIN - (Peer Reviewed Journal)

Obrenovich, M.E., Joseph, J.A., Atwood, C.S., Perry, G., Smith, M.A. 2002. Amyloid-2: a (life) preserver for the brain. Neurobiology of Aging.

PRACTICING CALORIC RESTRICTION OR EATING A DIET HIGH IN ANTIOXIDANTS: EQUIVALENT PATHS TO SUCCESSFUL AGING? - (Peer Reviewed Journal)

CASADESUS, G., SHUKITT HALE, B., JOSEPH, J.A. PRACTICING CALORIC RESTRICTION OR EATING A DIET HIGH IN ANTIOXIDANTS: EQUIVALENT PATHS TO SUCCESSFUL AGING?. NEUROBIOLOGY OF AGING. 23(5):747-69,2002.

PREDICTING THE FAILURE OF AMYLOID-BETA VACCINE - (Peer Reviewed Journal)

Smith, M.A., Atwood, C.S., Joseph, J.A., Perry, G. 2002. Predicting the failure of amyloid-beta vaccine. Lancet. 359:1864-1865.

EFFECTS OF FRUITS AND VEGETABLES ON LEVELS OF VITAMINS E AND C IN THE BRAIN AND THEIR ASSOCIATION WITH COGNITIVE PERFORMANCE - (Review Article)

MARTIN, A., CHERUBINI, A., ANDRES-LACUEVA, C., JOSEPH, J.A. EFFECTS OF FRUITS AND VEGETABLES ON LEVELS OF VITAMINS E AND C IN THE BRAIN AND THEIR ASSOCIATION WITH COGNITIVE PERFORMANCE. JOURNAL OF NUTRITION HEALTH AND AGING. 2nd Congress of International Academy Nutrition & Aging (IANA), Albuquerque (NM, USDA), July 10-12, 2002.

POTENTIAL ROLE OF DIETARY FLAVONOIDS IN REDUCING MICROVASCULAR ENDOTHELIUM VULNERABILITY TO OXIDATIVE AND INFLAMMATORY INSULTS - (Peer Reviewed Journal)

Youdim, K.A., Mcdonald, J., Kalt, W., Joseph, J.A. 2002. Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults. Journal of Nutritional Biochemistry. 13:282-288.

MUSCARINIC RECEPTOR SUBTYPE DETERMINES VULNERABILITY TO OXIDATIVE STRESS IN COS-7 CELLS - (Peer Reviewed Journal)

Joseph, J.A., Fisher, D.R., and Strain, J. Muscarinic receptor subtype determines vulnerability to oxidative stress in COS-7 cells. Free Rad. Biol. Med. 2002, 32: 153-161.

THE STATE VERSUS AMYLOID-BETA: THE TRAIL OF THE MOST WANTED CRIMINAL IN ALZHEIMER'S DISEASE - (Review Article)

Rottkamp, C.A., Atwood, C.S., Joseph, J.A., Akihiko, N., Perry, G., Smith, M.A. 2002. The state versus amyloid-beta: the trail of the most wanted criminal in alzheimer's disease. Peptides 23 (2002) 1333-1341.

THE STATE VERSUS AMYLOID-BETA: THE TRAIL OF THE MOST WANTED CRIMINAL IN ALZHEIMER'S DISEASE - (Review Article)

Rottkamp, C.A., Atwood, C.S., Joseph, J.A., Akihiko, N., Perry, G., and Smith, M.A. 2002. The State versus amyloid-beta: The trail of the most wanted criminal in Alzheimer's Disease. Peptides 23: 1333-1341.

EFFECTS OF EXPOSURE TO 56FE PARTICLES ON THE ACQUISITION OF A CONDITIONED PLACE PREFERENCE IN RATS - (Abstract)

Rabin, B. M., Shukitt-Hale, B., Joseph, J. A., and Denisova, N. Effects of exposure to 56Fe particles on the acquisition of a conditioned place preference in rats. Physica Medica 2001, 17 (Suppl. 1): 196-197.