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Role of PM-Associated Transition Metals in Exacerbating Infectious Pneumoniae in Exposed Rats

EPA Grant Number: R827351C007
Subproject: this is subproject number 007 , established and managed by the Center Director under grant R827351
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: EPA NYU PM Center: Health Risks of PM Components
Center Director: Lippmann, Morton
Title: Role of PM-Associated Transition Metals in Exacerbating Infectious Pneumoniae in Exposed Rats
Investigators: Zelikoff, Judith T.
Institution: NYU School of Medicine
EPA Project Officer: Stacey Katz/Gail Robarge,
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
RFA: Airborne Particulate Matter (PM) Centers (1999)
Research Category: Particulate Matter

Description:

Objective:

The objective of this research project is to determine the role that particulate matter (PM)-associated transition metal solubility and concentration might play in bringing about previously observed changes in host immunocompetence. To this end, Streptococcus pneumoniae-infected rats are exposed to artificially generated atmospheres containing soluble/insoluble forms of individual metals found at the highest concentrations in immunoreactive New York City (NYC) PM samples. Similar studies will then employ mixtures of the soluble/insoluble forms of the metals so as to ascertain whether the immunosuppression in PM-exposed hosts is dependent, at least in part, upon any interactions between the metals present. Immunotoxic effects of metal exposure on non-infected animals are also examined in these studies so as to determine the extent to which the PM-associated metals are capable of producing immunodysfunction in and of themselves.

Publications and Presentations:

Publications have been submitted on this subproject: View all 3 publications for this subproject | View all 95 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 2 journal articles for this subproject | View all 74 journal articles for this center

Supplemental Keywords:

particulate matter, PM, exposure, animal, rat, toxicology, metal, pneumonia, Streptococcus pheumoniae, immunotoxic. , ENVIRONMENTAL MANAGEMENT, Air, Scientific Discipline, Health, RFA, PHYSICAL ASPECTS, Toxicology, Risk Assessment, Risk Assessments, Analytical Chemistry, Health Risk Assessment, Physical Processes, Atmospheric Sciences, particulate matter, Environmental Chemistry, Environmental Monitoring, exposure assessment, ambient air quality, chemical characteristics, epidemelogy, metal absorption, human health risk, pneumonia, acute cardiovascular effects, air toxics, particulates, Sulfur dioxide, atmospheric particles, acute lung injury, air pollution, environmental risks, ambient air monitoring, atmospheric particulate matter, exposure, atmospheric aerosol particles, airborne particulate matter, human exposure, PM

Progress and Final Reports:
1999 Progress Report
2000 Progress Report
2001 Progress Report
2002 Progress Report
2003 Progress Report
Final Report


Main Center Abstract and Reports:
R827351    EPA NYU PM Center: Health Risks of PM Components

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827351C001 Exposure Characterization Error
R827351C002 X-ray CT-based Assessment of Variations in Human Airway Geometry: Implications for Evaluation of Particle Deposition and Dose to Different Populations
R827351C003 Asthma Susceptibility to PM2.5
R827351C004 Health Effects of Ambient Air PM in Controlled Human Exposures
R827351C005 Physicochemical Parameters of Combustion Generated Atmospheres as Determinants of PM Toxicity
R827351C006 Effects of Particle-Associated Irritants on the Cardiovascular System
R827351C007 Role of PM-Associated Transition Metals in Exacerbating Infectious Pneumoniae in Exposed Rats
R827351C008 Immunomodulation by PM: Role of Metal Composition and Pulmonary Phagocyte Iron Status
R827351C009 Health Risks of Particulate Matter Components: Center Service Core
R827351C010 Lung Hypoxia as Potential Mechanisms for PM-Induced Health Effects
R827351C011 Urban PM2.5 Surface Chemistry and Interactions with Bronchoalveolar Lavage Fluid (BALF)
R827351C012 Subchronic PM2.5 Exposure Study at the NYU PM Center
R827351C013 Long Term Health Effects of Concentrated Ambient PM2.5
R827351C014 PM Components and NYC Respiratory and Cardiovascular Morbidity
R827351C015 Development of a Real-Time Monitoring System for Acidity and Soluble Components in Airborne Particulate Matter
R827351C016 Automated Real-Time Ambient Fine PM Monitoring System

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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